Preparation method of hydroxyapatite biological ceramics with strontium cooperated with ordered micrometer structure for osteogenesis

Abstract

The invention relates to a preparation method of hydroxyapatite biological ceramics with strontium cooperated with an ordered micrometer structure for osteogenesis. The preparation method comprises the following steps: (1) preparing strontium doped hydroxyapatite powder; (2) uniformly mixing the strontium doped hydroxyapatite powder and a binder, placing the mixture in a mold with a bottom lined with an organic plastic mesh screen, dry pressing and molding, sintering at a high temperature, and cooling, thus obtaining the strontium doped hydroxyapatite ceramics. Compared with the prior art, byadopting the dry pressing and molding technology, the organic plastic mesh screen with a mesh aperture dimension of 25 to 75 micrometers is used as a template for regulating and controlling an orderedstructure, the structure with the surface having ordered micrometer patterns is prepared on the basis of the strontium doped hydroxyapatite, so that the hydroxyapatite biological ceramics have betteradhesion, proliferation and differentiation of osteoblast; and the preparation method is novel, simple, easy, and capable of preparing the strontium doped surface ordered micrometer structure hydroxyapatite biological ceramics having a synergistic osteogenic differentiation effect in a low-cost and large-scale manner without special equipment.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a method for preparing hydroxyapatite bioceramics in which strontium cooperates with ordered microstructures to form bones. Background technique [0002] Hydroxyapatite (Hydroxyapatite, HAp) is similar in composition and structure to human bone apatite, and is non-toxic, safe, and has good biocompatibility. In the body, under the action of body fluids, hydroxyapatite will partially degrade, release calcium and phosphorus, and participate in bone formation, thus having the effect of osteoconduction. However, HAp, as a substitute for extracellular matrix in bone tissue engineering, has relatively poor hydrophilicity, weak cell adsorption and poor osteoinductivity, so it is necessary to carry out necessary surface modification and chemical modification to improve surface biological activity and facilitate cell adhesion on the material. Attach, promote cell proliferat...

AI Technical Summary

Problems solved by technology

Although these technologies can prepare and regulate a certain patterned structure and size, they have many disadvantages. For example, the mask preparation process of photolithography technology is complicated, costly, and time-consuming; mechanical polishing and laser processing will cause thermal damage to bioceramic materials, etc.

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