Medical implant for improving cell osteogenesis performance and preparation method thereof

A technology for implants and performance, applied in the direction of bone implants, joint implants, joint implants, etc., can solve the problems of implant surgery failure, low processing efficiency, prosthesis loosening, etc., and speed up postoperative recovery , The effect of small processing heat and flexible processing methods

Inactive Publication Date: 2020-09-08
BEIHANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some problems in orthopedic implantation: it is difficult to completely integrate the implant and human bone interface, which will lead to serious problems such as prosthesis loosening and osteolysis after implantation, and the incidence of prosthesis loosening is as high as 10% to 25%. %, leading to failure of implant surgery
However, most of these methods have their own limitations, such as involving dangerous chemicals, complicated procedures, low processing efficiency, and greater dependence on the type, size, and shape of materials, etc.

Method used

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  • Medical implant for improving cell osteogenesis performance and preparation method thereof
  • Medical implant for improving cell osteogenesis performance and preparation method thereof
  • Medical implant for improving cell osteogenesis performance and preparation method thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0029] A method for preparing the above-mentioned medical implant for improving the osteogenic performance of cells, the flow process is as follows figure 2 As shown, it mainly includes the following steps:

[0030] (1) Grinding and polishing the surface of the medical implant material, and cleaning it with a degreasing cleaning agent;

[0031] (2) Utilize ultra-fast laser processing equipment to scan the medical metal material after step (1) cleaning, and obtain a super-hydrophilic structure on the surface of the material, and the processing process is carried out under the protection of an inert gas;

[0032] (3) Soak the laser-treated bioimplant material containing a superhydrophilic surface in a statin solution with a concentration of 1mMol / L, take out the sample after 1 minute, and dry it until the surface of the material is completely dry to obtain Medical implants coated with statins to improve osteogenesis.

[0033] Wherein, the laser parameters set in step (2) are: ...

Embodiment 1

[0036] (1): Take a TC4 titanium alloy sample with a thickness of 2 mm and polish it to 1200 mesh, place it in absolute alcohol for ultrasonic cleaning for 5 minutes, and dry it.

[0037] (2): Place the polished and cleaned sample on the workbench of the femtosecond laser processing system (wavelength 1064nm), set the laser power to 6W, the frequency to 100KHz, the scanning speed to 15mm / s, the scanning distance to 60mm, and the number of scanning 15 times, start the laser processing system to start processing, and obtain a super-hydrophilic surface structure.

[0038] (3): Immerse the processed titanium alloy sample in a 1mMol / L lovastatin drug solution, take it out after 60s, and dry it at room temperature until the solvent is completely volatilized.

Embodiment 2

[0040] (1): Take a 2mm thick 316L stainless steel sample and polish it to 1200 mesh, place it in absolute alcohol for ultrasonic cleaning for 5 minutes, and dry it.

[0041] (2): Place the polished and cleaned sample on the worktable of the femtosecond laser processing system (wavelength 1064nm), set the laser power to 4W, the frequency to 200KHz, the scanning speed to 20mm / s, the scanning distance to 80mm, and the number of scanning times 20 times, start the laser processing system to start processing, and obtain a super-hydrophilic surface structure.

[0042] (3): Immerse the processed stainless steel sample in a 1mMol / L simvastatin drug solution, take it out after 60s, and dry it at room temperature until the solvent is completely volatilized.

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Abstract

The invention discloses a medical implant for improving cell osteogenesis performance and a preparation method thereof. The polished and cleaned medical metal is subjected to laser processing so as toobtain a surface structure with super-hydrophilic performance, and a statin drug coating is prepared on the super-hydrophilic surface, so that the drug loading is more uniform and sufficient. The medical implant with the drug coating has the function of enhancing the osteogenesis performance of human cells, is beneficial to rapid and tight combination with human tissues after being implanted intoa human body, is beneficial to smooth implementation of a transplantation operation, and effectively avoids secondary injury caused by transplantation failure.

Description

technical field [0001] The invention relates to a medical implant for improving the osteogenic performance of cells and a preparation method thereof, belonging to the technical field of laser surface processing of medical materials. Background technique [0002] Today, with the advancement of medicine, implanting medical devices has become one of the most effective means of treating orthopedic diseases. As the population ages, the demand for high-performance medical implants continues to increase. However, there are still some problems in orthopedic implantation: it is difficult to completely integrate the implant and human bone interface, which will lead to serious problems such as prosthesis loosening and osteolysis after implantation, and the incidence of prosthesis loosening is as high as 10% to 25%. %, resulting in failure of implant surgery. At present, the main population receiving orthopedic transplantation is the elderly, and the failure of transplantation will ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/28A61L27/04A61L27/54A61F2/28A61F2/30B23K26/082B23K26/70
CPCA61F2/28A61F2/30767A61F2/30942A61F2002/3093A61F2002/3097A61L27/04A61L27/28A61L27/54A61L2300/216A61L2300/412A61L2400/18A61L2420/02B23K26/082B23K26/702
Inventor 管迎春崔智铨
Owner BEIHANG UNIV
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