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Pearl powder polyamino acid composite bone repair material with osteogenic activity, and preparation method and use thereof

A technology of polyamino acid and osteogenic activity, which is applied in medical science, tissue regeneration, prosthesis, etc., can solve the problem of lack of osteogenic activity, and achieve the effects of excellent mechanical properties, excellent application prospects and simple preparation method.

Inactive Publication Date: 2020-03-20
中鼎凯瑞科技成都有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, calcium phosphate ceramic matrix composites with apatite and collagen as the main components have been widely studied and applied, but they lack osteogenic activity.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1, pearl powder polyamino acid composite bone repair material of the present invention

[0055] Take ε-aminocaproic acid, γ-aminobutyric acid, alanine, proline, lysine, hydroxyproline respectively 104.94g, 4.12g, 3.56g, 4.61g, 5.85g, 5.24g and sea water Add 5.8g of pearl powder into a 250mL three-neck flask, dissolve and mix it with 100mL of distilled water, stir and heat up to 180°C under nitrogen protection, add 0.2mL of phosphoric acid solution with a concentration of 7.3mol / L for dehydration, and continue to heat up to 190°C ℃ to make it into a molten state for pre-polymerization for 3 hours, then raise the temperature to 220 ℃ for 1 hour, and cool to room temperature under the protection of nitrogen to obtain the pearl powder polyamino acid composite bone repair material.

[0056] The above-mentioned pearl powder polyamino acid composite bone repair material is crushed into particles with a diameter of 2-5mm, and the temperature of 210°C and the injectio...

Embodiment 2

[0058] Embodiment 2, pearl powder polyamino acid composite bone repair material of the present invention

[0059] Take ε-aminocaproic acid, γ-aminobutyric acid, alanine, phenylalanine, hydroxyproline, aspartic acid, glycine respectively 104.94g, 8.25g, 1.78g, 11.56g, 1.31g, Add 1.33g, 0.75g and 74.62g of freshwater pearl powder into a 250mL three-necked flask, dissolve and mix them with 100mL of distilled water, stir and heat up to 170°C under nitrogen protection, add 0.2mL of phosphoric acid solution with a concentration of 7.3mol / L, and carry out After dehydration, continue to heat up to 200°C to make it into a molten state for pre-polymerization for 3 hours, then raise the temperature to 240°C for 4 hours, and cool to room temperature under the protection of nitrogen to obtain the pearl powder polyamino acid composite bone repair material.

[0060] The above-mentioned pearl powder polyamino acid composite bone repair material is crushed into particles with a diameter of 2-5...

Embodiment 3

[0062] Embodiment 3, pearl powder polyamino acid composite bone repair material of the present invention

[0063] Take 91.82g, 15.47g, 4.455g, 7.31g, 6.56g of ε-aminocaproic acid, γ-aminobutyric acid, alanine, lysine, and hydroxyproline respectively, and add 107.6g of freshwater pearl powder into 250mL three In the flask, dissolve and mix with 100mL distilled water, stir and heat up to 180°C under the protection of nitrogen, add 0.2mL phosphoric acid solution with a concentration of 7.3mol / L, after dehydration, continue to heat up to 230°C to make it into a molten state. Prepolymerize for 4 hours, then raise the temperature to 250°C for 2 hours, and cool to room temperature under the protection of nitrogen to obtain the pearl powder polyamino acid composite bone repair material.

[0064] The above-mentioned pearl powder polyamino acid composite bone repair material is crushed into particles with a diameter of 2-5mm, and the temperature of 210°C and the injection pressure of 15...

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Abstract

The invention provides a pearl powder polyamino acid composite bone repair material with osteogenic activity, and a preparation method and application thereof. The composite bone repair material is made of a pearl powder and an amino acid through in situ polymerization, wherein the amino acid is composed of a gamma-amino acid and a non-gamma-amino acid, and the non-gamma-amino acid is an alpha-amino acid and / or an epsilon-amino acid. The composite bone repair material of the invention has excellent mechanical properties and adjustable degradation performance, is convenient for meeting different needs, does not cause damage to tissues after degradation, has high osteogenic activity, has good biocompatibility and biological activity, and can be used as an excellent, non-toxic and novel biomedical material. When the amino acid is a specific amino acid of the invention, the mechanical strength of the obtained composite bone repair material is significantly improved, the strength of human natural cortical bone is met, and the composite bone repair material can be used as a bone repair material with excellent performance. In addition, the preparation method is simple, has no complicatedprocess, is easy to operate, can realize industrialized production, and has excellent application prospects.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a pearl powder polyamino acid composite bone repair material with osteogenic activity, a preparation method and application thereof. Background technique [0002] As an important tissue supporting the human body, bone tissue will inevitably be damaged and attacked by diseases after long-term use, which makes the research on bone repair materials attract extensive attention. The repair and reconstruction of bone tissue is a difficult problem in clinical treatment and a research hotspot. In the field of spinal surgery, the existence of structures such as the spinal cord and intervertebral discs makes it difficult to implant repair materials during surgery, resulting in low bone formation efficiency and easy infection. At present, due to the lack of autologous bone and the immunogenicity of allogeneic bone, almost all bone repair materials commonly used in clinical p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/54A61L27/58
CPCA61L27/44A61L27/54A61L27/58A61L2300/30A61L2300/604A61L2430/02C08L77/04
Inventor 严永刚邓光进吴娅男戢觅之
Owner 中鼎凯瑞科技成都有限公司
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