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A bioactive ceramic material with both mechanical strength and degradability and preparation method thereof

A technology of bioactive ceramics and mechanical strength, which is applied in the field of bioactive ceramic materials and its preparation, can solve the problems that the preparation methods are difficult to obtain mechanical properties and biological activities, and achieve excellent bioactivity and degradation performance, and solve difficult problems. Effect of sintering and low porosity

Active Publication Date: 2020-12-08
上海积力威尔生物科技合伙企业(有限合伙)
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Calcium silicophosphate, as a newly developed biomaterial, is currently focused on the exploration and research of its preparation method and its biological properties. The previous research work shows that it is difficult to obtain the mechanical properties and biological activity of the current preparation method. excellent material system

Method used

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  • A bioactive ceramic material with both mechanical strength and degradability and preparation method thereof
  • A bioactive ceramic material with both mechanical strength and degradability and preparation method thereof
  • A bioactive ceramic material with both mechanical strength and degradability and preparation method thereof

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preparation example Construction

[0031] In a first aspect, the present invention provides a method for preparing a bioactive ceramic material having both mechanical strength and degradability, the method comprising the following steps:

[0032] (1) uniformly mixing iron oxide powder, calcium silicon phosphate powder and binder to obtain a mixture, and then molding the mixture to obtain a ceramic green body; and

[0033] (2) Sintering the ceramic green body obtained in step (1) (normal pressure sintering) to obtain a bioactive ceramic material having both mechanical strength and degradability.

[0034] In the present invention, the normal pressure sintering process is adopted, which is simple and controllable. Biosafe and non-toxic iron oxide is used as the sintering aid, silicon calcium phosphate is the main phase, and a binder is added. A bioactive ceramic material containing iron oxide with both mechanical strength and degradability was prepared by pressing and sintering, in which iron (Fe) in iron oxide is...

Embodiment 1

[0052] First weigh 0.5g of hexagonal iron oxide powder and 49.5g of silicon calcium phosphate powder, add 50g of deionized water, add 5.0g of polyvinyl alcohol aqueous solution with a solution concentration of 10wt%, and planetary ball mill for 3 hours to obtain a uniformly dispersed mixture , and then dried at 60°C for 12 hours, sieved to obtain a mixture with uniform particle size; then the obtained mixture was sequentially subjected to dry pressing (dry pressing molding pressure 50MPa, holding time 5min) and cold isostatic pressing (The pressure of cold isostatic pressing is 200MPa, and the pressure holding time is 5min). The length, width and height are 3×4×40mm. 2°C / min heating rate to 500°C for 2 hours to remove the binder, and then 2°C / min heating rate to 1250°C (final sintering temperature) for 2 hours, that is, the addition of iron oxide is 1wt%. Bioactive ceramic materials with both mechanical strength and degradability.

[0053] The bioactive ceramic material with ...

Embodiment 2

[0056] Embodiment 2 is basically the same as Embodiment 1, the difference is:

[0057] The amount of hexagonal iron oxide powder is 0.75g, the amount of silicon calcium phosphate powder is 49.25g, and the bioactive ceramic material with both mechanical strength and degradability in the amount of iron oxide added is 1.5wt%; other differences As shown in Table 1.

[0058] The cross-sectional morphology of the bioactive ceramic material with both mechanical strength and degradability obtained in this example is as follows: figure 2 shown. comprehensive figure 2 As can be seen from Table 1, with the increase of iron oxide addition, the densification degree of bioactive ceramic materials with both mechanical strength and degradability increases, and the bending strength increases significantly.

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Abstract

The invention relates to a bioactivity ceramic material with mechanical strength and degradation performance and a preparation method thereof. The method comprises the following steps of (1) uniformlymixing ferric oxide powder, calcium silicon-phosphate powder and bonding agents to obtain a mixture; then, shaping the mixture to obtain a ceramic blank; (2) sintering the obtained ceramic blank bodyto prepare the bioactivity ceramic material with mechanical strength and degradation performance. The method has the advantages that the process is simple; the process is controllable; the operationis easy; the sintering temperature is low, and the like. The bioactivity ceramic material with mechanical strength and degradation performance has the advantages of low porosity (the porosity can be lowered to about 1 percent), high anti-bending intensity (the anti-bending intensity can be improved to 55 to 100 MPa), good cell compatibility and the like. The material is particularly suitable for being used as a hard tissue restoration material, belongs to a biological and medical material with great potentials, and can be used as bone tissue restoration filling and dental restoration materials.

Description

technical field [0001] The invention belongs to the field of preparation of bioceramics, in particular to a bioactive ceramic material with both mechanical strength and degradability and a preparation method thereof. Background technique [0002] With the extension of human life span, the incidence of fractures caused by trauma, old age or disease is expected to rise to 400% by 2050, followed by huge medical consumption, it is estimated that the annual incidence of The cost of death / mortality will increase by about 8 billion US dollars accordingly, and the handling fee will increase by about 800,000 US dollars. It can be seen that the market potential of bone repair materials in the world is huge. From the perspective of domestic situation, my country is a big country with a population of 1.3 billion and more than 80 million disabled people. According to the report of the Civil Affairs Department, as of 2005, there were more than 15 million patients with limb disorders in my...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B35/447C04B35/622
CPCC04B35/447C04B35/622C04B2235/3272C04B2235/602C04B2235/6562C04B2235/96
Inventor 邓繁艳宁聪琴
Owner 上海积力威尔生物科技合伙企业(有限合伙)
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