Preparation method of nano zinc loaded hydroxyapatite porous bioceramic

A nano-hydroxyapatite and hydroxyapatite technology, applied in ceramic products, applications, household appliances, etc., can solve problems such as long-term pain at the bone graft site, mismatching bone formation rate of artificial bone, and loss of bone height. To achieve the effect of improving osteogenic induction ability, good osteogenic induction ability and reducing heat preservation time

Active Publication Date: 2019-07-26
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Delayed union or nonunion of bone graft, mismatch between degradation of artificial bone and bone formation rate, fragmentation and deformation of bone graft material, loss of height of bone block due to collapse after bone graft, infection after bone graft, long-term sinus formation, bone graft Long-term pain and other problems

Method used

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  • Preparation method of nano zinc loaded hydroxyapatite porous bioceramic
  • Preparation method of nano zinc loaded hydroxyapatite porous bioceramic
  • Preparation method of nano zinc loaded hydroxyapatite porous bioceramic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Using nano-zinc with a purity of ≥99.9% and a particle size of 50-60nm and nano-hydroxyapatite powder with a purity of ≥99.7% and a particle size of 80-100nm as raw materials, weigh nano-zinc at a mass ratio of 1:99 and nano-hydroxyapatite powder.

[0027] (2) Put the powder raw material weighed in step (1) into a vacuum ball mill tank, add stainless steel balls, absolute ethanol and polyethylene glycol as a dispersant, vacuumize to 10Pa, and then fill with argon with a purity of 99.999% Air, placed on a planetary ball mill, ball milled at a speed of 300r / min for 8h, dried and ground in a vacuum oven at 60°C to obtain a hydroxyapatite composite powder loaded with nano-zinc.

[0028] (3) The hydroxyapatite composite powder loaded with nano-zinc obtained in step (2) was uniformly mixed with the powder of ammonium bicarbonate, a pore-forming agent with a purity AR and an average particle size of 500 μm, at a mass ratio of 75:25 to obtain a mixed powder.

[0029] (4) P...

Embodiment 2

[0032] Using nano-zinc with a purity of ≥99.9% and a particle size of 50-60nm and nano-hydroxyapatite powder with a purity of ≥99.7% and a particle size of 80-100nm as raw materials, weigh nano-zinc and nano-hydroxyapatite at a mass ratio of 3:97 Apatite powder, other process steps and parameters are consistent with embodiment 1.

Embodiment 3

[0034] Using nano-zinc with a purity of ≥99.9% and a particle size of 50-60nm and nano-hydroxyapatite powder with a purity of ≥99.7% and a particle size of 80-100nm as raw materials, weigh nano-zinc and nano-hydroxyapatite at a mass ratio of 5:95 Apatite powder, other process steps and parameters are consistent with embodiment 1.

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Abstract

The invention discloses a preparation method of nano zinc loaded hydroxyapatite porous bioceramic and belongs to the technical field of biomecial material preparation. The method includes: weighing nano hydroxyapatite (99-93%) and nano zinc powder (1-7%) according to a mass ratio, ball-milling to obtain compound powder, mixing the compound powder with a pore former ammonium hydrogen carbonate, pressing after well mixing to obtain a blank, and utilizing discharging plasma sintering technology to prepare the nano zinc loaded hydroxyapatite porous bioceramic. The porous bioceramic prepared by themethod is uniform and pure in composition, porosity is controllable between 40-70%, compressive strength is 82-162Mpa, and pore size is 50-600um; by adding zinc, osteogenic inducing ability of the porous bioceramic is improved remarkably, and degradation rate is matched with osteogenesis rate; the porous bioceramic is suitable for bone stents and filling and repairing materials.

Description

technical field [0001] The invention relates to a method for preparing nano-loaded zinc hydroxyapatite porous bioceramics, which belongs to the technical field of biomedical material preparation. Background technique [0002] In recent years, with the rapid development of my country's national economy, the improvement of people's living standards, the aging of the population, and the significant improvement of medical and health standards, more and more orthopedic patients are caused by work-related injuries, traffic accidents, bone tumors, bone tuberculosis and other diseases. At present, the clinically used bone materials are mainly autologous bone and allogeneic bone. Autologous bone is the most ideal bone material, but there are problems such as insufficient source of autologous bone and complications of the donor site (such as infection, skin necrosis, and permanent defect of the donor site); The bone material of choice, but it has problems such as graft rejection, dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B38/02C04B35/447C04B35/626C04B35/64
CPCC04B35/447C04B35/6261C04B35/64C04B38/02C04B2235/3284C04B2235/5454C04B2235/6562C04B2235/6567C04B2235/666
Inventor 张玉勤朱斌孟增东罗丽琳何远怀
Owner KUNMING UNIV OF SCI & TECH
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