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Traditional Chinese medicine compound gel suppository for contraception and preparation method thereof

A compound gel suppository and traditional Chinese medicine technology, applied in the field of natural medicine research, can solve the problems of increasing pelvic inflammatory disease, bacterial infection of reproductive system diseases, inability to protect against disease transmission, irregular vaginal bleeding, etc., to increase sexual life interest, Promote drug absorption, no toxic side effects

Inactive Publication Date: 2018-06-22
DALIAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The use of latex condoms is a common contraceptive method. According to literature reports, the contraceptive failure rate of all condoms is about 18%, and this contraceptive method is not suitable for latex allergies; emergency contraception mainly includes oral levonorgestrel Ketones, oral progesterone receptor modulators - ulipristal acetate, high-dose compound estrogen and progesterone tablets, this method cannot be used for a long time, and is not suitable for overweight or obese people, and cannot protect against disease transmission ; The intrauterine device will increase the user's chances of pelvic inflammatory disease, bacterial infection, and reproductive system diseases, and can cause increased menstrual flow, bleeding and other symptoms. When it is removed, bleeding and pain are inevitable; compound oral contraceptives, It mainly contains male and female hormones and is also a popular contraceptive method, but its side effects are obvious, causing dizziness, headache, nausea and vomiting, fatigue and lethargy, irregular vaginal bleeding, breast swelling, weight gain, and thromboembolism

Method used

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  • Traditional Chinese medicine compound gel suppository for contraception and preparation method thereof

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Embodiment 1

[0023] A traditional Chinese medicine compound gel suppository for contraception, the active ingredients are flavescens and pulsatilla, and the mass ratio of flavescens to pulsatilla is 3:1; the suppository also includes carbomer, β-cyclodextrin, glycerin, sodium hydroxide , ethanol, distilled water.

[0024] The preparation method of suppository of the present invention comprises the following steps:

[0025] (1) Take 150.0g of Sophora flavescens and 50.0g of Pulsatilla pulsatillae mixture and dry them in a vacuum oven for 12 hours. After taking them out, heat and reflux them with 8 times the amount of 60% ethanol for 3 times, each time for 2 hours. Combine the extracts and suspend them with a rotary evaporator. , concentrated in a water bath, set the volume in a 100ml volumetric flask with distilled water, and obtain a mother liquor containing 2g crude drug per 100ml for subsequent use;

[0026] (2) Swell 10.0g of carbomer with 250ml of distilled water for 24 hours to form ...

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Abstract

The invention belongs to the field of research of natural medicines and particularly relates to a traditional Chinese medicine compound gel suppository for contraception and a preparation method thereof. The effective components of the suppository provided by the invention are lightyellow sophora roots and Chinese pulsatilla roots, and the mass ratio of the lightyellow sophora roots to the Chinesepulsatilla roots is 3:1; and the suppository also comprises Carbomer, beta-cyclodextrin, glycerol, sodium hydroxide, ethanol and distilled water. The preparation method comprises the following steps:drying the lightyellow sophora roots and the Chinese pulsatilla roots according to the ratio, then performing reflux extraction, performing rotary evaporateion and concentration on the extracting solution, and metering the volume of the distilled water to obtain a mother solution for later use, wherein each 100ml of the mother solution contains 2g of crude medicines; and mixing the mother solution with ethanol and glycerol to obtain a mixture, then mixing the mixture with a carbomer solution in which beta-cyclodextrin is added, performing uniform mixing, then performing injection molding andcooling, eliminating the overflowing part, and performing mold release to obtain the suppository. The suppository provided by the invention has a good contraception effect, also has a lubrication function, and is safe and effective.

Description

technical field [0001] The invention belongs to the field of natural medicine research, in particular to a traditional Chinese medicine compound gel suppository for contraception and a preparation method thereof. Background technique [0002] According to the statistics of the World Health Organization, there are 48 million induced abortions in the world every year, and 13 million in my country, of which more than 50% are under the age of 24, and the repeated abortion rate of this group is more than 30%. Abortion among teenage girls is on the rise year by year. Studies have shown that there is a positive correlation between induced abortion and reproductive tract infectious diseases and infertility, and surgical abortion in the second trimester is related to the incidence of serious complications of about 1%. Therefore, it is very necessary to effectively reduce the induced abortion rate, and this research direction has always been a hot spot at home and abroad. [0003] T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/02A61K47/32A61K36/71A61P15/18A61P15/00
CPCA61K9/0034A61K9/02A61K36/489A61K36/71A61K47/32A61K2300/00
Inventor 王惠国钟雪龙文月汤红翠李雪莹
Owner DALIAN UNIV
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