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Application of a compound with antibacterial activity

An antibacterial activity and compound technology, applied in the field of medicinal chemistry, can solve the problems of new medicinal microbial strains and the reduction of the probability of new antibiotics, and achieve good development prospects and good inhibitory activity.

Active Publication Date: 2020-10-02
BINZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

After decades of in-depth excavation, the probability of discovering new medicinal microbial strains and new antibiotics from ordinary habitats has been greatly reduced, while medicinal microorganisms in extreme environments (such as: oceans, deserts, salt lakes, glaciers, etc.) have not yet been developed on a large scale. exploration and development

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  • Application of a compound with antibacterial activity
  • Application of a compound with antibacterial activity
  • Application of a compound with antibacterial activity

Examples

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Embodiment 1

[0023] Preparation of Antibacterial Compounds

[0024] Streptomyces griseus was streak-inoculated on ISP2 semi-seawater solid medium, cultured at 28°C for 3 days, a small amount of bacteria was inoculated into ISP2 semi-seawater liquid medium, cultured on a shaking table at 28°C at 180rpm for 10 days, and the fermentation product was harvested. Filtrate the fermentation product to obtain fermentation broth and mycelium, extract the fermentation broth through XAD-16 macroporous adsorption resin column, crush and extract the mycelium with acetone, concentrate the extract under reduced pressure, extract with ethyl acetate after combination, and concentrate under reduced pressure to obtain total extract. The total extract is subjected to silica gel column chromatography, and gradient elution is carried out to collect methanol: dichloromethane is 5:95 (volume ratio) of the eluted components, and the collected eluted components are subjected to ODS reverse-phase column chromatograph...

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Abstract

The invention provides an antibacterial active compound as well as a purification preparation method and application thereof. The compound is prepared by purifying from streptomyces and can be used for preparing antibacterial drugs and biological pesticides. Studies show that the compound has broad-spectrum antibacterial activity, can significantly inhibit the growth of fungi and bacteria, and hasthe value of development of new antibacterial drugs.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to an antibacterial compound, its purification and preparation method, and its application in the preparation of antibacterial drugs and biological pesticides. Background technique [0002] Due to the abuse of antibiotics, drug-resistant bacteria and infections caused by drug-resistant bacteria, especially Gram-negative drug-resistant bacteria, have reached an unprecedented level worldwide, and the therapeutic effect of original antibiotics has been greatly reduced. New diseases The rapid discovery of highly efficient and high-quality new antibiotics has become an important topic all over the world. Antibiotics are secondary metabolites of medicinal microorganisms represented by actinomycetes, and the discovery of new medicinal microbial resources, including new species, is one of the foundations for the discovery of new antibiotics. After decades of in-depth excavation, the prob...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D491/107A61P31/10A01P3/00A01P1/00C12P17/18C12R1/545
CPCC07D491/107C12P17/18
Inventor 张淑敏谢则平郭琳杨小平杨芹冯玲玲张露
Owner BINZHOU MEDICAL COLLEGE