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Kidney-tonifying bone-invigorating liquid and preparation method thereof

A technology for nourishing the kidney and strengthening the bone and formula, which is applied in the directions of bone diseases, pharmaceutical formulations, dispersion liquid transportation, etc., can solve the problems such as precipitation of the nourishing kidney and nourishing bone liquid, and achieves the effects of simple preparation method, good stability and controllable conditions.

Inactive Publication Date: 2018-06-29
GUANGDONG YILI GROUP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In summary, it is urgent to find a method to solve the problem of precipitation after long-term storage of traditional Yishenbuguye

Method used

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  • Kidney-tonifying bone-invigorating liquid and preparation method thereof
  • Kidney-tonifying bone-invigorating liquid and preparation method thereof
  • Kidney-tonifying bone-invigorating liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1. Yishen Bugu Liquid of the present invention and its preparation

[0025] Chinese medicine formula: Drynaria fortunei 45g, Polygonum 126g, Poria 63g, Dipsacus 63g, White peony 44g, Angelica 63g, Codonopsis 75g, Rehmannia glutinosa 63g, Polygonatum 63g, Chinese wolfberry 63g, Natural copper (calcined, vinegar quenched) 45g and dried tangerine peel 16g;

[0026] Preparation:

[0027] S1. Take the prescription amount of Drynaria fortunei, Polygonum multiflorum, Poria, Dipsacus, Angelica, Codonopsis, Rehmannia, Polygonatum, Chinese wolfberry, natural copper and dried tangerine peel, add 2.74kg of water, decoct for 2 hours, filter, add 1.37 to the filter residue Kg water, decocted for 2 hours, filtered, combined the filtrate, concentrated to each 1ml solution equivalent to 1g of the original medicinal material (ie 685ml), add twice the volume of ethanol (ie 1370ml), stir, and let stand at 5℃ for 16h, Filter and recover ethanol to obtain a mixed medicinal extract;

[0028...

Embodiment 2

[0033] Example 2. Yishen Bugu Liquid of the present invention and its preparation

[0034] Chinese medicine formula: Drynaria fortunei 45g, Polygonum 126g, Poria 63g, Dipsacus 63g, White peony 44g, Angelica 63g, Codonopsis 75g, Rehmannia glutinosa 63g, Polygonatum 63g, Chinese wolfberry 63g, Natural copper (calcined, vinegar quenched) 45g and dried tangerine peel 16g;

[0035] Preparation:

[0036] S1. Take the prescription amount of Drynaria fortunei, Polygonum multiflorum, Poria, Dipsacus, Angelica, Codonopsis, Rehmannia, Polygonatum, Chinese wolfberry, natural copper and dried tangerine peel, add 4.11kg of water, decoct for 2 hours, filter, add 2.055 to the filter residue kg water, decocted for 2 hours, filtered, combined the filtrate, concentrated to each 1ml solution was equivalent to 1g of the original medicinal material (ie 685ml), added twice the volume of ethanol (ie 1370ml), stirred, and allowed to stand at 10°C for 16h, Filter and recover ethanol to obtain a mixed medici...

Embodiment 3

[0042] Example 3. Yishen Bugu Liquid of the present invention and its preparation

[0043] Chinese medicine formula: Drynaria fortunei 45g, Polygonum 126g, Poria 63g, Dipsacus 63g, White peony 44g, Angelica 63g, Codonopsis 75g, Rehmannia glutinosa 63g, Polygonatum 63g, Chinese wolfberry 63g, Natural copper (calcined, vinegar quenched) 45g and dried tangerine peel 16g;

[0044] Preparation:

[0045] S1. Take the formula of Drynaria fortunei, Polygonum multiflorum, Poria, Dipsacus, Angelica, Codonopsis, Rehmannia, Polygonatum, Chinese wolfberry, natural copper and dried tangerine peel, add 3.425kg of water, decoct for 2 hours, filter, add 2.055 to the filter residue kg water, decocted for 2 hours, filtered, combined the filtrate, concentrated to 1g of the original medicinal material per 1ml solution (ie 685ml), added 2 times the volume of ethanol (ie 1370ml), stirred, and allowed to stand at 6°C for 16h, Filter and recover ethanol to obtain a mixed medicinal extract;

[0046] S2. Take...

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Abstract

The invention discloses kidney-tonifying bone-invigorating liquid and a preparation method thereof. The preparation method comprises the steps: S1. weighing medicinal materials such as rhizoma drynariae, radix polygoni multiflori, poria cocos and radix dipsaci, adding water into the medicinal materials, carrying out decocting twice, carrying out filtration, merging filtrate, carrying out concentrating, then, adding ethanol, of which the volume is double that of concentrate, into the concentrate, carrying out stirring, carrying out standing, carrying out filtration, and recovering the ethanol,so as to obtain a mixed extract; S2. adding water into radix paeoniae alba, carrying out decocting twice, carrying out filtration, merging filtrate, and carrying out concentrating, so as to obtain concentrate; S3. adding water, of which the volume is 1 time that of concentrate, into the concentrate, adding egg white, heating the mixture till boiling, carrying out cooling, carrying out filtration,adjusting the pH value to 3.5 to 3.8, carrying out standing, and carrying out filtration, so as to obtain a radix paeoniae alba extract; S4. mixing the mixed extract and the radix paeoniae alba extract, adding saccharose, liquor and a preservative, adjusting the pH value to 4.0 to 4.4, carrying out filtration, adding water to fix volume, carrying out uniform stirring, carrying out encapsulation, and carrying out sterilization, thereby obtaining the kidney-tonifying bone-invigorating liquid. According to the kidney-tonifying bone-invigorating liquid and the preparation method thereof, the problem of the existing kidney-tonifying bone-invigorating liquid that precipitates occur soon after heated sterilization is effectively solved, and the obtained kidney-tonifying bone-invigorating liquid is free of precipitation and is unchanged in treatment effect after two or more years of placement.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a kidney-tonifying and tonifying liquid and a preparation method thereof. technical background [0002] Yishen Buguye is a product included in the drug standards (Volume 10 of Prescriptions of Chinese Medicine) issued by the Ministry of Health, and the standard number is WS 3 -B-2020-95, has the effect of nourishing liver and kidney, strengthening muscles and bones. It is used for liver and kidney deficiency, low back pain and muscle fracture. Its prescription: Drynaria fortunei 45g, Polygonum 126g, Poria 63g, Dipsacus 63g, White peony 44g, Angelica 63g, Codonopsis 75g, Rehmannia glutinosa 63g, Polygonatum 63g, Chinese wolfberry 63g, Natural copper (calcined, vinegar quenched) 45g and dried tangerine peel 16g. Preparation method: the above twelve Chinese medicinal materials, decocted twice, 2 hours each time, filtered, combined the filtrate, concentrat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61K9/08A61P1/16A61P13/12A61P29/00A61P19/04A61P19/08A61K33/26
CPCA61K9/0095A61K33/26A61K36/076A61K36/126A61K36/185A61K36/232A61K36/344A61K36/65A61K36/704A61K36/71A61K36/752A61K36/804A61K36/815A61K36/8969A61K47/46A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 曾胜曾佐达梁烽焱张浩潘洁丽
Owner GUANGDONG YILI GROUP PHARMA
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