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A method for increasing the solubility of resveratrol in water by preparing resveratrol/formaldehyde resin nanospheres and the resin nanospheres

A water solubility and resveratrol technology, applied in the field of functional materials, can solve the problems of low loading rate of resveratrol and waste of resveratrol, and achieve uniform and adjustable product size, high biological activity, and mild reaction conditions Effect

Active Publication Date: 2019-12-17
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although these methods can increase the solubility of resveratrol in water, the loading rate of resveratrol is relatively low, thus causing waste of resveratrol in the loading process

Method used

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  • A method for increasing the solubility of resveratrol in water by preparing resveratrol/formaldehyde resin nanospheres and the resin nanospheres
  • A method for increasing the solubility of resveratrol in water by preparing resveratrol/formaldehyde resin nanospheres and the resin nanospheres
  • A method for increasing the solubility of resveratrol in water by preparing resveratrol/formaldehyde resin nanospheres and the resin nanospheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] 9.8mL of water, 4mL of ethanol, 0.1mL of formaldehyde solution (37wt%) and 0.1mL of ammonia water (25wt%) were mixed successively and stirred at room temperature, and finally 1mL of ethanol-dissolved monomer containing 20mg of resveratrol was added. After stirring at room temperature for 45 minutes, centrifuge at a speed of 15,000 rpm for 10 minutes for a total of 4 times to obtain resveratrol / formaldehyde resin nanospheres with an average size of 150 nm. Finally, the resin nanospheres can be dissolved in water to obtain a nanoparticle solution with a concentration of 200 mg / mL.

Embodiment 2

[0021] 11.55mL water, 2.75mL ethanol, 0.1mL formaldehyde aqueous solution (37wt%), 0.1mL ammonia water (25wt%) were mixed successively at room temperature and stirred at room temperature, and finally 1mL ethanol-dissolved monomer containing 20mg resveratrol was added. After stirring at room temperature for 45 minutes, centrifuge at a speed of 15,000 rpm for 10 minutes for a total of 4 times to obtain resveratrol / formaldehyde resin nanospheres with an average size of 120 nm. Finally, the resin nanospheres can be dissolved in water to obtain a nanoparticle solution with a concentration of 180 mg / mL.

Embodiment 3

[0023] 11.8mL of water, 2mL of ethanol, 0.1mL of formaldehyde solution (37wt%) and 0.1mL of ammonia water (25wt%) were mixed successively and stirred at room temperature, and finally 1mL of ethanol-dissolved monomer containing 20mg of resveratrol was added. After stirring at room temperature for 45 minutes, centrifuge at a speed of 15,000 rpm for 10 minutes for a total of 4 times to obtain resveratrol / formaldehyde resin nanospheres with an average size of 110 nm. Finally, the resin nanospheres can be dissolved in water to obtain a nanoparticle solution with a concentration of 160 mg / mL.

[0024] Examples 1-3 illustrate that the size of the resveratrol / formaldehyde resin nanospheres can be adjusted by changing the ratio of water to ethanol, and the size of the nanospheres decreases with the increase of the proportion of water used.

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Abstract

A method of increasing water solubility of resveratrol by preparing resveratrol / formaldehyde resin nanospheres, and the resin nanospheres. The invention belongs to the technical field of functional materials. The method includes steps of: blending water and an organic solvent which is mutually soluble with water; and under stirring at room temperature, successively adding formaldehyde, alkali anda resveratrol monomer, and continuously stirring the mixture at room temperature and performing centrifugal purification to obtain the resveratrol / formaldehyde resin nanospheres. The method has gentlereaction conditions and can be carried at room temperature, wherein the product has uniform and adjustable size and the method has good experimental repeatability, so that the method is suitable forindustrial production. The resveratrol / formaldehyde resin nanospheres can reach 150 mg / mL even higher in concentration, which is at least 5000 times of the solubility of the resveratrol in water. In addition, the resin nanospheres can maintain high bioactivity relative to the resveratrol monomer; and through further surface modification, the resin nanospheres can be applied to the field of nano-medicines more effectively. The method can supply potential application prospect for targeted therapy by using the resveratrol.

Description

technical field [0001] The invention belongs to the technical field of functional materials, and specifically relates to a method for increasing the solubility of resveratrol in water by constructing resveratrol / formaldehyde resin nanospheres and the resin nanospheres. This method can effectively increase the solubility of resveratrol in water. Compared with resveratrol monomer, the resin nanosphere still has higher biological activity of resveratrol monomer. Background technique [0002] Resveratrol is a natural polyphenol compound, which is rich in Polygonum cuspidatum and grapes, because of its high biological safety and obvious anti-tumor, anti-cardiovascular and cerebrovascular diseases, anti-oxidation, anti-bacterial and anti-inflammatory, Various biological activities such as lowering blood sugar have attracted the attention of researchers in recent years. However, due to the poor water solubility of resveratrol, the solubility in water is only 0.03mg / mL, and the or...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G8/20
CPCC08G8/20
Inventor 张皓王文婧封文洁葛睿
Owner JILIN UNIV