Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Gene fusion detection device

A gene fusion and sequencing technology, applied in special data processing applications, instruments, electrical digital data processing, etc., can solve the problems of low false positives, high resource requirements, slow detection speed, etc., to reduce the number of comparisons and reduce resource requirements. , the effect of improving stability

Active Publication Date: 2018-07-06
ANNOROAD GENE TECH BEIJING +2
View PDF5 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CREST is currently one of the mainstream algorithms for detecting Fusion genes. Its main advantage is low false positives, but it also has disadvantages such as slow detection speed, high resource requirements, and the need for assembly.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Gene fusion detection device
  • Gene fusion detection device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] Embodiment 1 The device for detecting gene fusion of the present invention

[0104] The device for detecting gene fusion in this embodiment has:

[0105] The sequencing data acquisition module is configured to acquire sequencing data; the sequencing data is the sequencing data obtained by using a paired-end sequencing (Paired-end Sequencing, PE sequencing) method.

[0106] Comparison module: it is connected with the sequencing data acquisition module, and is used to compare the obtained sequencing data with the reference sequence, and obtain the corresponding positions of the sequencing fragments in the gene; this module uses bwa software to find the sequencing fragments in the gene The corresponding position in the file, and form a bam format file; the bam file includes description information (qname), sequence information (seq), alignment position (POS), bit identifier (flag), and alignment quality value of each sequenced fragment in the bam file (MAPQ), brief compar...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a gene fusion detection device. The device comprises a sequencing data acquisition module, a comparison module, a discrimination module, a true fusion breakpoint judgment module and an output module. The gene fusion detection device has the advantages of being high in detection speed, low in resource requirement and high in stability.

Description

technical field [0001] The invention relates to the field of gene fusion detection, in particular to a device and method for detecting gene fusion. Background technique [0002] Fusion gene is a kind of chromosomal structural variation that is clinically very important and plays a key role in the development of cancer. Accurate fusion gene detection results can provide a reference for clinical anti-cancer target drug treatment and prognosis assessment. [0003] The detection techniques traditionally used to detect fusion genes are mainly based on genetic methods, such as FISH. However, relatively low resolution and throughput limit the application of this method in the detection of complex epithelial cancers. [0004] With the development of next-generation sequencing technology, a large number of algorithms for detecting fusion genes have emerged. In the gene fusion detection algorithm, the confirmation of the breakpoint directly affects the judgment of the detection res...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G06F19/20
CPCG16B25/00
Inventor 董永芳荆瑞琳董超王旺玄兆伶李大为梁峻彬陈重建
Owner ANNOROAD GENE TECH BEIJING
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com