Application of Deep Sea Fungus 3a00421 and Its Fermentation Compounds

A technology of polyketide compounds and drugs, which is applied to the active ingredients of hydroxyl compounds, fermentation, fungi, etc., can solve problems such as adverse reactions, and achieve the effect of promoting effective applications and good application prospects

Active Publication Date: 2020-09-22
THIRD INST OF OCEANOGRAPHY STATE OCEANIC ADMINISTATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the existing chemically synthesized anti-inflammatory drugs still have unavoidable adverse reactions, researchers are paying more and more attention to finding and developing new anti-inflammatory drugs from natural products.

Method used

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  • Application of Deep Sea Fungus 3a00421 and Its Fermentation Compounds
  • Application of Deep Sea Fungus 3a00421 and Its Fermentation Compounds
  • Application of Deep Sea Fungus 3a00421 and Its Fermentation Compounds

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Embodiment 1

[0036] In this embodiment, the deep-sea fungus Graphostroma sp.3A00421 is used as a material to prepare the fermentation compound of the deep-sea fungus Graphostroma sp.3A00421 shown in formula (I) to formula (XXV). The specific steps are as follows:

[0037] (1) The strains were cultured in PDA plate medium at 25°C for 3 days, then the fresh mycelium was cut and inoculated in 1L Erlenmeyer flasks (30 pieces), and each Erlenmeyer flask was equipped with 80g rice and 120mL distilled water , these Erlenmeyer flasks were placed under the condition of 25°C, cultured statically for 28 days, and the fermentation product was extracted after the fermentation;

[0038] (2) The fermentation product obtained in step (1) is extracted 3 times with ethyl acetate respectively to obtain an organic extract;

[0039] (3) Concentrate the organic extract obtained in step (2) to dryness and redissolve it with methanol, then extract it 3 times through petroleum ether (PE), and finally evaporate the...

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Abstract

The invention discloses the application of the deep-sea fungus Graphstroma sp. 3A00421 and its fermentation compound. The deep-sea fungus Graphstroma sp.3A00421 of the present invention is preserved in the China Center for Type Culture Collection, the preservation number is CCTCC NO: M 2017637, the preservation address is Wuhan University, China, and the preservation date is October 30, 2017. The fermented compound of the deep-sea fungus Graphstroma sp.3A00421 of the invention has anti-allergic and anti-inflammatory activities, and can be used to prepare anti-allergic drugs or anti-inflammatory drugs. The invention not only provides a new compound source for the research and development of anti-allergic and anti-inflammatory drugs, is of great significance to the development of marine drugs in my country, but also promotes the effective application of deep-sea microbial resources and has a good application prospect.

Description

technical field [0001] The invention belongs to the application field of marine fungus extract compounds, more specifically, the invention relates to the application of deep-sea fungus Graphostroma sp.3A00421 and its fermentation compounds. Background technique [0002] Food allergy refers to the strong reaction of a certain tissue, organ or even the whole body after some people eat a certain food, resulting in various dysfunction or tissue damage. The incidence of food allergy has gradually increased in the past few decades, posing a threat to human life and health. Food allergic reactions are mainly mediated by serum immunoglobulin E (IgE), and this allergic reaction is usually accompanied by an increase in the content of specific immunoglobulin IgE. [0003] At present, there is no active drug that inhibits allergenic food antigens, and the current treatment options for food allergy are avoidance of contact with allergens or desensitization therapy. The use of dietary i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/14C12P17/14C12P17/06C12P17/04C12P7/42C12P7/26C12P7/02A61K31/421A61K31/12A61K31/343A61K31/192A61K31/366A61K31/235A61K31/122A61K31/047A61K31/19A61P29/00A61P37/08C12R1/645
CPCA61K31/047A61K31/12A61K31/122A61K31/19A61K31/192A61K31/235A61K31/343A61K31/366A61K31/421C12P7/02C12P7/26C12P7/42C12P17/04C12P17/06C12P17/14C12N1/145C12R2001/645
Inventor 杨献文牛四文夏金梅谢春兰骆祝华李增鹏
Owner THIRD INST OF OCEANOGRAPHY STATE OCEANIC ADMINISTATION
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