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Nuclear magnetic resonance method for acquiring J coupling constant amplified spectrogram

A nuclear magnetic resonance and spectrogram technology, which is applied in the direction of using nuclear magnetic resonance spectrum for measurement, magnetic resonance measurement, and magnetic variable measurement, can solve problems such as data discontinuity, pulse imperfect accumulation, and resolution drop, and achieve improved resolution. Rate, Facilitate Measurement, Interpret Accurate Results

Inactive Publication Date: 2018-07-13
XIAMEN UNIV
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Problems solved by technology

However, real-time J-coupling amplification will be affected by data discontinuity and imperfect accumulation of pulses, etc., resulting in a decrease in resolution

Method used

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  • Nuclear magnetic resonance method for acquiring J coupling constant amplified spectrogram
  • Nuclear magnetic resonance method for acquiring J coupling constant amplified spectrogram
  • Nuclear magnetic resonance method for acquiring J coupling constant amplified spectrogram

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Embodiment Construction

[0019] Below in conjunction with accompanying drawing and embodiment, the present invention will be further described:

[0020] A kind of nuclear magnetic resonance method that obtains the spectrogram of J coupling amplification, it is characterized in that comprising the following steps:

[0021] 1) collecting the NMR one-dimensional spectrum of the sample;

[0022] 2) Measure the pulse width of the 90-degree hard pulse of the sample;

[0023] 3) Set the data block length t in an experiment int ;t int 10ˉ20 milliseconds;

[0024] 4) Determine the number of indirect dimension sampling points ni, namely t 1 the number of increments;

[0025] 5) Set the value of the echo unit time Δ; and determine the J coupling magnification n with this, the magnification n=(t int +2Δ) / t int ;

[0026] 6) Use the measured 90-degree hard pulse as the excitation pulse of the pulse sequence, after experiencing t 1 After a period of time, go through i*Δ echo time again, then apply a 180-de...

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Abstract

The invention provides a nuclear magnetic resonance method for acquiring a J coupling constant amplified spectrogram. Firstly, a 90-degree hard pulse is applied to turn a magnetization vector from a Zdirection to an XY plane. After time t1, i*delta time is delayed, a 180-degree hard pulse is applied, i*delta time is delayed again, and then sampling is started. The t1 is increased at equal intervals in each time of sampling. The 'i*delta-180-egree pulse-i*delta' is a spin echo module, only J coupling evolution is performed in the meantime, and chemical displacement evolution is reunited. Therefore, in each time of sampling, J coupling evolution time is 2 delta longer than chemical displacement evolution time, so that a J coupling constant can be effectively amplified. After experiments, starting time tint data of data acquired by sampling in each time are extracted and sequentially spliced to obtain new one-dimensional data, and then Fourier transformation is performed to obtain the Jcoupling constant amplified spectrogram.

Description

technical field [0001] The invention relates to a nuclear magnetic resonance multidimensional spectrum method, in particular to a nuclear magnetic resonance method for obtaining a one-dimensional spectrum with J coupling constant amplification. Background technique [0002] NMR one-dimensional spectrum is the most convenient and commonly used NMR spectrum. In one-dimensional NMR spectra, peaks subject to multiple couplings often show complex peak groups, and small J couplings often cannot be measured due to line width and resolution. One way to solve this problem is to amplify the J-coupling constant so that the J-coupling constant, which is too small to be measured, becomes measurable. Therefore, the J coupling constant amplification method is an effective and practical method. In 2015, Austrian scientist Klaus Zangger proposed a real-time NMR method for amplifying the J coupling constant (S. Glanzer, K. Zangger, Visualizing unresolved scalar couplings by real-time J-upsc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R33/46
Inventor 林雁勤曾庆陈忠
Owner XIAMEN UNIV
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