Accurate processing method for multi-gene combination-based faecal DNA methylation detection data

Abstract

The invention provides an accurate processing method for multi-gene combination-based faecal DNA methylation detection data. The method comprises the steps of firstly obtaining to-be-detected gene data, and then obtaining to-be-detected gene sample data from the to-be-detected gene data; performing multiple multi-gene combination detections on the to-be-detected gene sample data to obtain positivedetection rates of the combination detections; performing a Chi-square test on the positive detection rates of the combination detections to obtain a P value, and if the P value is greater than a setP value ratio, determining current multi-gene combination detection as an optimal multi-gene combination detection mode; and finally performing detection on the to-be-detected gene data in the optimal multi-gene combination detection mode to obtain current detection data. The combination detection mode is more accurate in detection result, high in positive detection rate and specificity and low in cost, and can be used for screening clinical sensitivity and specificity of early-stage CRC (Colorectal Cancer).

Description

Technical field [0001] The invention relates to the field of medical technology, in particular to a method for accurately processing fecal DNA methylation detection data combined with multiple genes. Background technique [0002] Colorectal cancer (CRC) is the most common malignant tumor of the digestive tract. In recent years, with the continuous improvement of living standards, the incidence of CRC has been increasing year by year. However, most cases are diagnosed in the middle and advanced stages, and the prognosis is poor. Good, high mortality rate. Its early symptoms are not typical, and if detected early, it can significantly improve the prognosis, increase the patient’s survival, and reduce the mortality rate. At present, the commonly used clinical screening methods for colorectal cancer mainly include electronic colorectal endoscopy and fecal occul tblood test (FOBT), which are limited due to their shortcomings such as invasive examination or low positive detection rate...

AI Technical Summary

Problems solved by technology

However, the detection rate and specificity of single-gene fecal DNA methylation detection in diagnosing CRC are low. Although multi-gene methylation detection can improve the detection rate, with the increase in the number of genes for joint detection, the cost will also increase. High-cost detection methods are obviously not suitable for large-scale early screening of CRC. Therefore, looking for an optimal gene combination that has a high positive detection rate and specificity and can reduce detection costs is essential for CRC screening. Significant

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