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Pharmaceutical composition and application thereof, oral cavity cleaning and caring product, health-care product and medicine for oral cavity

A composition and drug technology, applied in the directions of drug combination, oral care, cosmetic preparations, etc., can solve the problems of unsuitable long-term repeated use and harm to people's health.

Active Publication Date: 2018-07-27
YUNNAN BAIYAO GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Oral ulcers and periodontal disease are common, frequently-occurring, and chronic diseases. Their existence will not only bring great pain and inconvenience to patients, but also cause various systemic diseases due to the existence of excessive dental bacteria. Sexual diseases are harmful to people's health, but there is no better oral cleaning care product or oral health care product that can be used for a long time and has good safety and effect. The medicines are mainly antibiotics or hormone products, so it is not suitable long-term repeated use

Method used

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  • Pharmaceutical composition and application thereof, oral cavity cleaning and caring product, health-care product and medicine for oral cavity
  • Pharmaceutical composition and application thereof, oral cavity cleaning and caring product, health-care product and medicine for oral cavity
  • Pharmaceutical composition and application thereof, oral cavity cleaning and caring product, health-care product and medicine for oral cavity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The present embodiment provides a kind of pharmaceutical composition, it comprises:

[0031] The active ingredient of Yunnan Baiyao in 0.2 parts by weight;

[0032] 0.09 parts by weight of Periplaneta americana extract.

[0033] Wherein, the preparation method of the active ingredient of Yunnan Baiyao comprises:

[0034] Mix Yunnan Baiyao powder meeting the Pharmacopoeia standard with 7 times the amount of 60% ethanol, heat and reflux at 70°C for 1.5 hours, repeat the extraction twice under the same conditions, combine the extracts, and use a three-effect decompression concentrator at 70°C Concentrate under reduced pressure under certain conditions, until the relative density of the concentrated solution reaches 1.2, use macroporous adsorption resin as the adsorbent, perform column chromatography, first elute with water, remove water-soluble impurities, and elute the active ingredients with 60% ethanol to decolorize large Pore ​​adsorption resin, decolorization, activ...

Embodiment 2

[0038] The present embodiment provides a kind of pharmaceutical composition, it comprises:

[0039] The active ingredient of Yunnan Baiyao in 0.4 parts by weight;

[0040] 0.48 parts by weight of Periplaneta americana extract.

[0041] Wherein, the preparation method of the active ingredient of Yunnan Baiyao and the extract of Periplaneta americana is consistent with that of Example 1.

Embodiment 3

[0043] The present embodiment provides a kind of pharmaceutical composition, it comprises:

[0044] The active ingredient of Yunnan Baiyao in 1 part by weight;

[0045] The American cockroach extract of 0.5 weight part.

[0046] Wherein, the preparation method of the active ingredient of Yunnan Baiyao comprises:

[0047] Mix Yunnan Baiyao powder that meets the pharmacopoeia standard with 5 times the amount of 95% ethanol, heat and reflux at 50°C for 2 hours, repeat the extraction twice under the same conditions, combine the extracts, and use a three-effect decompression concentrator at 60°C Concentrate under reduced pressure under certain conditions until the relative density of the concentrated solution reaches 1.0, use macroporous adsorption resin as the adsorbent, perform column chromatography, first elute with water, remove water-soluble impurities, and elute the active ingredients with 90% ethanol to decolorize large Pore ​​adsorption resin, for decolorization, after de...

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PUM

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Abstract

The invention provides a pharmaceutical composition and application thereof, an oral cavity cleaning and caring product, a health-care product and a medicine for oral cavity and relates to the fieldsof daily chemical products, health-care products and medicines. The pharmaceutical composition is prepared from a Yunnan Baiyao active component and American cockroach extract. The pharmaceutical composition has prevention and improvement effects on oral cavity related diseases, such as gingivitis, bleeding gums, periodontitis and oral ulcer; the pharmaceutical composition can be used for effectively preventing and repairing occurrence and development of illness conditions at an initial phase of the periodontitis, so that the morbidity of periodontal diseases is reduced and lowered; meanwhile,the occurrence of the oral ulcer is inhibited and the pharmaceutical composition has a good effect in the aspect of promoting the healing of the oral ulcer and can be used for preparing the medicineand health-care product or the oral cavity cleaning and caring product for treating or preventing the gingivitis, the bleeding gums, the periodontitis or the oral ulcer.

Description

technical field [0001] The present invention relates to the fields of daily chemical products, health care products and medicines, in particular to a pharmaceutical composition and its application, as well as oral cleaning care products, oral health care products and medicines. Background technique [0002] According to statistics, the incidence rate of periodontal disease among adults in my country is about twice that of dental caries, and those with unhealthy periodontals are as high as 85%. The cause of periodontal disease is gingivitis at first, and gingival bleeding is one of the most significant symptoms of periodontal disease in its early stage. However, except for bleeding, periodontal disease has no other obvious symptoms at the beginning, so it is not easy to attract people's attention. Therefore, the symptoms of periodontal disease will gradually worsen inadvertently. If measures are not taken in time and allowed to continue to develop, in severe cases, the alveo...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61K36/258A61P1/02A61P7/04A61K8/98A61K8/9789A61K8/97A61Q11/00
CPCA61K8/97A61K8/9789A61K8/987A61K35/63A61K36/00A61K36/258A61K2236/333A61K2236/51A61K2236/55A61P1/02A61P7/04A61Q11/00A61K2300/00
Inventor 王明辉高鹰张秋霞宁科功刘萍伍鹏蔡英李劲峰
Owner YUNNAN BAIYAO GROUP
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