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Gelsmium elegans toxicity-reducing efficacy-maintaining matching composition and preparation method thereof

A composition and technology of glyphus, which is applied in the field of traditional Chinese medicine compatibility and processing, can solve the problem of not fundamentally solving the problem of glyphus toxicity, and achieve the effect of maintaining drug efficacy and reducing toxicity

Active Publication Date: 2018-08-10
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Scholars at home and abroad have explored ways to reduce the adverse reactions of geckos, but they have not fundamentally solved the toxicity of geckos.

Method used

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  • Gelsmium elegans toxicity-reducing efficacy-maintaining matching composition and preparation method thereof
  • Gelsmium elegans toxicity-reducing efficacy-maintaining matching composition and preparation method thereof
  • Gelsmium elegans toxicity-reducing efficacy-maintaining matching composition and preparation method thereof

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preparation example Construction

[0025] A preparation method of a compatible composition with attenuated and long-lasting effect of kelp, comprising the following steps:

[0026] Step 1: Weigh 5-15g of the dry product of the same plant, soak it for 1-3 hours, decoct it in water for 2 times, 30 minutes each time, combine the filtrates, concentrate and transfer to 10mL to obtain the extract ;

[0027] Step 2: Weighing 12-20 g of leech coarse powder, soaking in 70% ethanol and refluxing extraction for 3 times, mixing the extracts obtained by 3 times of immersion and reflux extraction to obtain leech extract;

[0028] Step 3: Weigh 1-5g of horsefly, dehydrate in 95% alcohol for 21-3h, then transfer to acetone solution to degrease for 2h, place the dehydrated and degreased sample overnight, dry, crush to powder, dissolve in 0.01mol / In L salt water, carry out 3 times soaking and obtain filtrate, the filtrate obtained by soaking 3 times is mixed, makes fly insect extract;

[0029] Step 4: Weigh 12-20 g of rhubarb...

Embodiment 1

[0048] A compatible composition with attenuated poison and long-lasting effect of ginkgo, prepared from the following materials: 10 g of dry ginkgo, 16 g of leech meal, 1 g of horsefly, 16 g of rhubarb, and 2 g of peach kernel.

[0049] A preparation method of a compatible composition with attenuated and long-lasting effect of kelp, comprising the following steps:

[0050] Step 1: Weigh 10g of the dried Glycyrrhiza officinalis from the same plant, soak it for 2 hours, decoct it in water for 2 times, 30min each time, combine the filtrates, concentrate and transfer to 10mL to obtain the Gelkinia officinalis extract;

[0051] Step 2: Weigh 16g of leech coarse powder, soak in 70% ethanol and reflux extract 3 times, wherein the first time is soaking leech coarse powder in 10 times the mass of 70% ethanol for 4h, reflux extraction for 2h, and the second The second time is to soak the leech coarse powder after the first reflux extraction in 8 times the mass of 70% ethanol for 4h, and...

Embodiment 2

[0058] A compatible composition with attenuated poison and long-lasting effect of ginkgo, prepared from the following materials: 5 g of dry ginkgo, 12 g of leech meal, 1 g of horsefly, 12 g of rhubarb, and 1 g of peach kernel.

[0059] A preparation method of a compatible composition with attenuated and long-lasting effect of kelp, comprising the following steps:

[0060] Step 1: Weigh 5g of the dried medicinal herb of the same plant, soak for 1 hour, decoct in water twice for 30 minutes each time, combine the filtrates, concentrate and transfer to a volume of 10mL, and then obtain the extract of Glycyrrhizae;

[0061] Step 2: Weigh 12g of leech coarse powder, soak in 70% ethanol and reflux extract 3 times, wherein the first time is to soak leech coarse powder in 10 times the mass of 70% ethanol for 4h, reflux extraction for 1h, and the second The second time is to soak the leech coarse powder after the first reflux extraction in 8 times the mass of 70% ethanol for 4h, and ref...

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Abstract

The invention relates to the technical field of traditional Chinese medicine matching and processing, in particular to a gelsmium elegans toxicity-reducing efficacy-maintaining matching composition and a preparation method thereof. By matching gelsmium elegans having toxicity and improving proportion and processing method of leech, gadfly, rheum officinale and peach kernel in Didang decoction, compared with conventional Didang decoction processing methods, the preparation method includes: adopting a mode of mixing before respective extraction, wherein an alcohol extraction mode is adopted forleech and rheum officinale to replace processing methods of mixing and decocting ingredients in conventional processing technology; mixing leech extract, gadfly extract, rheum officinale extract and peach kernel extract which are prepared respectively, concentrating to obtain powder, using 25-35mL of pure water for dissolving to obtain the Didang decoction, and mixing the Didang decoction with gelsmium elegans extract to obtain the composition. The composition can reduce the toxicity of gelsmium elegans and maintain efficacy of the same.

Description

technical field [0001] The invention relates to the technical field of compatibility and processing of traditional Chinese medicines, in particular to a compatible composition with attenuated toxicity and long-lasting effect of glyphs and a preparation method thereof. Background technique [0002] Gelphis is a plant of the genus Equestrianaceae, which is a world-renowned poisonous plant. Traditional Chinese medicine has recorded and applied it for a long time, and "Shen Nong's Materia Medica" listed it as inferior, saying that it is mainly used for gold sores, apoplexy, cough, upper qi, edema, and killing ghosts. Since the 1980s, the scope of clinical application of glyphus has gradually expanded, showing that it has good anti-tumor, sedative and analgesic, mydriasis, and immune function and other pharmacological functions, especially in prolonging the survival of liver cancer patients and tumor patients. Pain relief has unique advantages. Abroad, the American Drug Index (...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61K36/56A61P35/00A61P27/02A61P37/02A61K35/62A61K35/64
CPCA61P27/02A61P35/00A61P37/02A61K35/62A61K35/63A61K36/56A61K36/708A61K36/736A61K2236/39A61K2236/331A61K2236/333A61K2300/00
Inventor 李德森吴水生
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE