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Preparation method of compound nerve-calming traditional Chinese medicine oral liquid

A traditional Chinese medicine oral liquid and a technology for traditional Chinese medicine, which are applied in the field of preparation of traditional Chinese medicine oral liquid for soothing the nerves, can solve the problems of excessive precipitation, poor storage stability of clarity, influence on product appearance and quality, etc., and achieve improved clarity, improved clarity and Effects on storage stability

Inactive Publication Date: 2018-08-17
SHANGHAI KAIBAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During the further development of the patented medicine, the applicant found that when the traditional Chinese medicine composition was made into an oral liquid preparation, there were problems of poor clarity and storage stability, and more precipitation would occur after storage, which would affect the product. appearance and quality

Method used

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  • Preparation method of compound nerve-calming traditional Chinese medicine oral liquid
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  • Preparation method of compound nerve-calming traditional Chinese medicine oral liquid

Examples

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Effect test

preparation Embodiment 1

[0028] Preparation Example 1: Anshen Traditional Chinese Medicine Oral Liquid 1

[0029] (1) Prescription: 3000 grams of groundnut branches and leaves, 1500 grams of salvia miltiorrhiza, 2 grams of sodium benzoate, stevia, and L-sodium glutamate.

[0030] (2) Preparation method:

[0031] Take the branches and leaves of peanuts and salvia miltiorrhiza, mix them after crushing, add 13 times the volume of drinking water to the powder of medicinal materials, soak overnight, decoct for extraction for 1 hour, keep warm for 2 hours, filter to obtain filtrate and medicinal residues. Add 15 times the volume of drinking water to the dregs, decoct for 1 hour, keep warm for 2 hours, filter to obtain a filtrate, and discard the dregs.

[0032] Combine the filtrates extracted twice, concentrate under reduced pressure until the volume of the concentrated solution is a concentrated solution with a relative density of 1.2g crude drug / ml, cool to below 25°C, add ethanol in an amount 4 times th...

preparation Embodiment 2

[0047] Preparation Example 2: Anshen Traditional Chinese Medicine Oral Liquid 2

[0048] (1) Prescription: 3000 grams of groundnut branches and leaves, 1500 grams of salvia miltiorrhiza, 3 grams of sodium benzoate, 5 grams of Tween-80, 2 grams of nutmeg volatile oil, and stevia.

[0049] (2) Preparation method:

[0050] Take the branches and leaves of peanuts and salvia miltiorrhiza, mix them after crushing, add 13 times the volume of drinking water to the powder of medicinal materials, soak overnight, decoct for extraction for 1 hour, keep warm for 2 hours, filter to obtain filtrate and medicinal residues. Add 15 times the volume of drinking water to the dregs, decoct for 1 hour, keep warm for 2 hours, filter to obtain a filtrate, and discard the dregs.

[0051] Combine the filtrates extracted twice, concentrate under reduced pressure until the volume of the concentrated solution is a concentrated solution with a relative density of 1.2g crude drug / ml, cool to below 25°C, ad...

preparation Embodiment 3

[0055] Preparation Example 3: Anshen Traditional Chinese Medicine Oral Liquid 3

[0056] (1) Prescription: 3000 grams of groundnut branches and leaves, 1500 grams of salvia miltiorrhiza, 2 grams of sodium benzoate, stevia, and L-sodium glutamate.

[0057] (2) Preparation method:

[0058] Take the branches and leaves of peanuts and salvia miltiorrhiza, mix them after crushing, add 13 times the volume of drinking water to the powder of medicinal materials, soak overnight, decoct for extraction for 1 hour, keep warm for 2 hours, filter to obtain filtrate and medicinal residues. Add 15 times the volume of drinking water to the dregs, decoct for 1 hour, keep warm for 2 hours, filter to obtain a filtrate, and discard the dregs.

[0059] The filtrates extracted twice were combined, concentrated under reduced pressure until the volume of the concentrated solution was a concentrated solution with a relative density of 1.2 g crude drug / ml, and cooled to below 25°C. Add ethanol in an a...

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Abstract

The invention discloses a preparation method of a compound nerve-calming traditional Chinese medicine oral liquid; the method comprises the steps of weighing traditional Chinese medicine raw materialsaccording to a prescription proportion, carrying out water decoction of the traditional Chinese medicine raw materials, then carrying out alcohol precipitation extraction, adding a flavoring agent and a pH regulator, carrying out subpacking sterilization and the like. The preparation method disclosed by the invention improves the problem of poor clarity of an oral liquid produced by a same-prescription process in the prior art by improving the concentration degree, the alcohol precipitation concentration, the concentration degree after the alcohol precipitation and the sterilization process conditions after the water decoction and extraction of the medicinal materials. The method not only improves appearance characteristics of the oral liquid product but also improves the storage stability of the preparation.

Description

technical field [0001] The invention relates to the technical field, in particular to a preparation method of an nerve-soothing traditional Chinese medicine oral liquid. Background technique [0002] Peanut branches and leaves are the aerial parts of peanuts, which contain a variety of volatile components. Since the 1970s, there have been reports on the sedative and hypnotic effects of peanut leaf extracts, but the further development and utilization of the medicinal effects of groundnut branches and leaves extracts has not yet matured. . [0003] The applicant owns an invention patent with the patent number ZL200410016412.0 and titled "A Traditional Chinese Medicine Composition, Preparation Method and Application with Calming Liver, Activating Blood and Tranquilizing Effects". The traditional Chinese medicine compositions disclosed in this patent are various oral preparations composed of extracts of Arachis branches and leaves, Salvia miltiorrhiza and pharmaceutical adjuva...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/08A61K47/12A61K47/26A61K47/44A61P25/20
CPCA61K9/0095A61K36/48A61K36/537A61K47/12A61K47/26A61K47/44A61K2236/331A61K2236/39A61K2236/53A61P25/20A61K2300/00
Inventor 张小利穆竟伟薛东升
Owner SHANGHAI KAIBAO PHARMA
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