Inclusion technology for volatile oil

Abstract

The invention discloses an inclusion technology for volatile oil. The inclusion technology comprises the following steps of diluting volatile oil obtained by extracting herba menthae and herba schizonepetae with ethanol as a dispersant in advance, then performing inclusion on the diluted volatile oil with beta-cyclodextrin, and performing drying for 3-5 hours at a temperature of 50 DEG C or below,wherein the volume ratio of the volatile oil to the ethanol is (1 to 3) to (1 to 5), the mass ratio of the volatile oil to the beta-cyclodextrin is (1 to 5) to (1 to 8), the inclusion time is 1.5-2.5hours, and the inclusion temperature is 30-40 DEG C. By adopting the inclusion technology provided by the invention, the obtained volatile oil has higher inclusion rate and drug stability.

Description

[0001] This application is a divisional application of an invention patent application (application number: 201610378512.0, application date: 2016.06.01, invention name: Chuanxiong Chatiao Granules and its preparation method). technical field [0002] The invention relates to a preparation method of a traditional Chinese medicine, in particular to an inclusion process of volatile oil. Background technique [0003] The original prescription of Chuanxiong Chatiao Granules comes from "Taiping Huimin Heji Bureau Prescription" Chuanxiong Chatiao San. It is mainly composed of Chuanxiong, Baizhi, Qianghuo, Asarum, Fangfeng, Mint, Nepeta, and Licorice. It has the effect of dispelling wind and relieving pain. Headache due to pathogenic wind, or aversion to cold, fever, and stuffy nose, the clinical curative effect is definite. [0004] The Chinese Pharmacopoeia 2010 Edition contains the Chuanxiong Cha Tiaosan traditional Chinese medicine preparation. The formula is Chuanxiong 120g, A...

AI Technical Summary

Problems solved by technology

It is not advisable to simply increase the dose in theory, because the increase in the dose will lead to the extraction of more other ingredients in the two medicinal materials, thus affecting the compatibility of the drugs

In addition, the Chuanxiong tea tune granules of the aforementioned prior art are dissolved in ethanol and sprayed directly, so there are problems in the stability of the medicine. At the same time, because of the characteristics of the method of taking the granules, they need to be uniformly dispersed with water, and the solubility of the active substance becomes a key factor to exert its biological properties. The key point of activity, the volatile oil has poor water solubility and low bioavailability, and the clinical use is limited

[0007] With respect to the present invention, prior art has following room for improvement: 1, the formula of prior extract, its curative effect needs to be further improved

2. The incomplete extraction of menthol, the active ingredient of mint in Chuanxiong Chatiao Granules, affects the effect of mint on clearing the wind and clearing the head, treating both symptoms and root causes, and further affects the advantage of Chuanxiong Chatiao San, which is "just feel the atmosphere, and cure everything".

3. The mint and Nepeta mixed volatile oil in Chuanxiong Chatiao Granules are dissolved in ethanol and sprayed directly. There are problems with the stability and solubility of the drug, which affects the efficacy of the drug.

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