A porous titanium-based nanocomposite material for hard tissue materials and its preparation method and application

A composite material and porous titanium technology, applied in the direction of tissue regeneration, electrolytic coating, surface reaction electrolytic coating, etc., can solve the problems of unsatisfactory biological activity, inability to reduce adverse effects, poor comprehensive mechanical properties, etc., and achieve strong binding force , Good dispersibility, combined compact effect

Active Publication Date: 2021-09-21
湖南早晨纳米机器人有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

For example, the patent CN103014801A discloses a preparation method of electrodeposition for titanium-based hydroxyapatite biomedical composite materials. The pretreated titanium or titanium alloy substrate is prepared on the surface of the titanium base by constant current or constant voltage electrodeposition. A layer of hydroxyapatite coating can improve the affinity and biocompatibility with the body, promote the growth of new bone, the preparation process is simple, and the reaction avoids high temperature, but there are still poor comprehensive mechanical properties. The performance is considerable, but the biological activity is not ideal, etc., the elastic modulus is large, the rigidity is high, and the adverse effects of the "stress shielding" effect cannot be reduced

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  • A porous titanium-based nanocomposite material for hard tissue materials and its preparation method and application
  • A porous titanium-based nanocomposite material for hard tissue materials and its preparation method and application
  • A porous titanium-based nanocomposite material for hard tissue materials and its preparation method and application

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preparation example Construction

[0082] The present invention also provides a preparation method of the porous titanium-based composite material, comprising the following steps:

[0083] 1) After the pretreated titanium-based material is subjected to anodization process and annealing treatment, a titanium-based material with a porous structure surface is obtained;

[0084] After mixing the chitosan and vancomycin mixed solution, calcium salt, phosphorus salt and water, adjust the pH value to obtain the first mixed solution;

[0085] 2) after electrodepositing the titanium-based material with the porous structure surface obtained in the above steps and the first mixed solution, a semi-finished product is obtained;

[0086] 3) After the semi-finished product obtained in the above steps is subjected to alkali soaking treatment, a porous titanium-based composite material is obtained.

[0087] The selection, ratio and corresponding selection principles of raw materials in the preparation method of the present inv...

Embodiment 1

[0134] Titanium alloys with a size of 40 × 20 × 1 mm were first polished with sandpaper in turn, and then placed in acetone, absolute ethanol, and deionized water for ultrasonic cleaning for 10 min. Phosphoric acid: sulfuric acid: water = 1:3:10 (volume ratio) polishing solution for electrochemical polishing, electrochemical polishing is carried out in an oil bath device at 85 ° C, stirring speed is 800 r / min, polishing adopts constant current method, electric current Density is 25A / dm 2 , the polishing time is 10s, and the polished sample is ultrasonically cleaned with deionized water for 10min. After completion, take it out and rinse it, dry it with cold air, and then use scotch tape to encapsulate the side that does not participate in the reaction according to 20 × 20mm for use to control the reaction. zone and prevent edge polarization.

[0135] Anodizing adopts constant pressure method, hydrofluoric acid solution is used as electrolyte, wherein hydrofluoric acid concentr...

Embodiment 2

[0149] Titanium alloys with a size of 40 × 20 × 1 mm were first polished with sandpaper in turn, and then placed in acetone, absolute ethanol, and deionized water for ultrasonic cleaning for 15 min. Phosphoric acid: sulfuric acid: water = 1:3:10 (volume ratio) polishing solution for electrochemical polishing, electrochemical polishing is carried out in an oil bath device at 87 ° C, stirring speed is 1000r / min, polishing adopts constant current method, electric current Density is 35A / dm 2 , the polishing time is 15s, and the polished sample is ultrasonically cleaned with deionized water for 13min. After completion, it is taken out and rinsed, dried with cold air, and then the side that does not participate in the reaction is packaged with scotch tape 20 × 20mm for use to control the reaction. zone and prevent edge polarization.

[0150] The anodic oxidation adopts the constant pressure method, the hydrofluoric acid solution is used as the electrolyte, the hydrofluoric acid con...

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Abstract

The invention provides a porous titanium-based composite material, comprising a porous titanium-based material, a hydroxyapatite layer compounded on the porous titanium-based material, and a chitosan compound compounded on the hydroxyapatite layer Sugar‑Vancomycin. The invention reduces or eliminates the "stress shielding" effect through the porous titanium-based material, and has stronger binding force. The porous titanium-based composite material provided by the present invention further has chitosan-vancomycin compounded on the outer surface, and the combination of the two greatly solves the problem of infection after osteogenic transplantation at the present stage, which leads to inflammation or functional degradation of the graft, and causes transplantation Failed, and there are problems with binding force and short drug release time. The porous titanium-based composite material provided by the present invention can well combine HAp, chitosan-functional medicine, and the composite coating formed by utilizing the porous structure, and has better dispersion, stronger binding force, and obvious slow-release time Improve, play a long-term antibacterial effect.

Description

technical field [0001] The present invention relates to the technical field of biomedical materials, and relates to a porous titanium-based composite material and its preparation method and application, in particular to a porous titanium-based nanocomposite material for hard tissue materials and its preparation method, in terms of biomedical materials Applications. Background technique [0002] With the acceleration of population aging and the sharp increase of various accidental injuries, the number of patients with hard tissue defects is increasing. According to the forecast of the United Nations Organization for Economic Cooperation and Development, by 2020, the resulting hard tissue repair products will The market cap will reach $800 billion. [0003] As an important part of biomedical materials, hard tissue materials play an important role in repairing defective human hard tissues (bones, joints, etc.) and reconstructing lost physiological functions. Bone defect repai...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/42A61L27/46A61L27/48A61L27/54A61L27/32A61L27/34C25D11/26C25D15/00
CPCA61L27/06A61L27/12A61L27/20A61L27/32A61L27/34A61L27/54A61L27/56A61L2300/404A61L2300/406A61L2430/02C25D11/26C25D15/00C08L5/08
Inventor 皮立波孙若为温景成孙一绮杨志
Owner 湖南早晨纳米机器人有限公司
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