Method for separating isopentene flavonoid compounds from flos paulowniae and application

A technology of prenyl flavonoids and compounds, which is applied in the field of medicine, can solve problems such as no public reports, etc., and achieve the effect of novel and unique preparation methods and remarkable economic and social benefits

Pending Publication Date: 2018-08-17
HENAN UNIV OF CHINESE MEDICINE
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  • Abstract
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Problems solved by technology

So how to extract new active ingredients from Paulownia flowers, and realize the application in cardioprotective drugs, there is no public report so far

Method used

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  • Method for separating isopentene flavonoid compounds from flos paulowniae and application
  • Method for separating isopentene flavonoid compounds from flos paulowniae and application
  • Method for separating isopentene flavonoid compounds from flos paulowniae and application

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Embodiment Construction

[0053] The specific implementation of the present invention will be described in detail below in combination with specific situations.

[0054] In the specific implementation of the present invention, a method and application of isolating prenyl flavonoids from Paulownia flowers, the method comprises the following steps: 1. Preparation of components Fr.5-1~Fr.5-5, method It is: grind 6Kg of paulownia flowers to crush, extract 4 times with 50% water-containing acetone by volume concentration, use 60KG of each extract, combine the extracts, concentrate and dry the extracts to obtain the first dried product, disperse and dissolve with water, and use Petroleum ether, ethyl acetate, n-butanol extraction, petroleum ether extraction 5 times, each dosage 3L, ethyl acetate extraction 8 times, each dosage 3L, n-butanol extraction 8 times, each dosage 3L, concentrated and dried, Obtain petroleum ether part 50g, ethyl acetate part 220g, n-butanol part 112g and remaining water part success...

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Abstract

The invention relates to a method for separating isopentene flavonoid compounds from flos paulowniae and application. The isopentene flavonoid compounds separated from the flos paulowniae are paulownione D, paulownione E, paulownione F and paulownione G. The method includes steps of 1, preparing components from Fr.5-1 to Fr.5-5.2; 2, preparing the compounds paulownione D and paulownione E; 3, preparing the compounds paulownione F and paulownione E. The method and the application have the advantages that effects of protecting cardiac muscles can be realized by the compounds prepared by the aidof the method, and the compounds can be effectively used for preparing cardiac muscle protection medicines; the method is novel and unique, can be used for preparing medicines for protecting H9c2 cells against damage due to lipopolysaccharide and has obvious economic and social benefits, and good effects can be realized.

Description

technical field [0001] The invention relates to medicine, in particular to a method and application for isolating prenyl flavonoids from Paulownia flowers. Background technique [0002] Paulownia flower is the dried flower of Paulownia fortunei (Seem.) Hemsl, a plant of the family Scrophulariaceae. It is widely distributed in my country and has a large number. It is one of the traditional Chinese medicines and has a wide range of pharmacological activities. Among traditional medicines, Paulownia flowers are mostly used to treat diseases such as chronic bronchitis and pneumonia. With the development of science and technology, new technologies and methods are emerging in the field of drug research, and herbal medicines have the advantages of naturalness and low toxicity compared with chemical medicines. Gradually become a research focus of experts and scholars. More medicinal value of Paulownia flower has been gradually excavated, in order to widely use this medicinal plant i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/30C07D311/32C07D311/40A61P9/00
CPCC07D311/30A61P9/00C07D311/32C07D311/40
Inventor 郑晓珂李苗张靖柯李孟吕锦锦张志广冯卫生
Owner HENAN UNIV OF CHINESE MEDICINE
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