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A kind of pharmaceutical use of Chaihu Guizhi decoction

A technique of Guizhi and Bupleurum, which is applied in the field of pharmaceutical use of Bupleurum Guizhi Decoction, and can solve the problems of incomplete control of infection, serious drug resistance and the like.

Active Publication Date: 2021-01-29
BEIJING FRIENDSHIP HOSPITAL CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine treats bacterial infections mostly from the perspective of antibacterial, and uses a variety of antibiotics to sterilize and inhibit bacteria. However, the infection situation has not been completely controlled, and the problem of drug resistance is becoming more and more serious, which has certain limitations[4]

Method used

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  • A kind of pharmaceutical use of Chaihu Guizhi decoction
  • A kind of pharmaceutical use of Chaihu Guizhi decoction
  • A kind of pharmaceutical use of Chaihu Guizhi decoction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0118] Embodiment 1 A kind of pharmaceutical use of Bupleurum Guizhi Decoction

[0119] A drug packaging combination, which contains 11.2g of Bupleurum Guizhi Decoction and 9mg of tigecycline;

[0120] Preparation method of Bupleurum Guizhi Decoction: Weigh 63g of Guizhi, Scutellaria, Ginseng, Peony, and Ginger, 168g of Bupleurum, 87g of Pinellia, 42g of Licorice, 244g of Jujube, fully moisten with 8 times the amount of water, let it soak for 30 minutes, and heat to boil Afterwards, decoct for 30 minutes, filter with 3 layers of gauze while it is hot, add 6 times the amount of water to the filter residue and reflux to extract for 20 minutes, filter, combine the filtrates, concentrate to 750ml, and obtain a liquid medicine with a concentration of 1.14g / ml, and store it in cold storage for later use.

Embodiment 2

[0121] Embodiment 2 A kind of pharmaceutical application of Bupleurum Guizhi Decoction

[0122] A drug packaging combination, which contains 0.1g of freeze-dried powder of Bupleurum Guizhi Decoction and 9mg of tigecycline;

[0123]Preparation method of Bupleurum Guizhi Decoction: Weigh 63g of Guizhi, Scutellaria, Ginseng, Peony, and Ginger, 168g of Bupleurum, 87g of Pinellia, 42g of Licorice, 244g of Jujube, fully moisten with 8 times the amount of water, let it soak for 30 minutes, and heat to boil Afterwards, decoct for 30 minutes, filter with 3 layers of gauze while it is hot, add 6 times the amount of water to the filter residue and reflux to extract for 20 minutes, filter, combine the filtrate, concentrate to 750ml, and obtain a medicinal solution with a concentration of 1.14g / ml, and refrigerate for later use;

[0124] The preparation method of the freeze-dried powder of Bupleurum Guizhi Decoction: 10g of Bupleurum Guizhi Decoction refrigerated for later use; add 1.0g of...

Embodiment 3

[0126] Embodiment 3 A kind of pharmaceutical application of Bupleurum Guizhi Decoction

[0127] A pharmaceutical composition, which contains 0.1 g of freeze-dried powder of Bupleurum Guizhi Decoction and 9 mg of tigecycline;

[0128] Preparation method of Bupleurum Guizhi Decoction: Weigh 63g of Guizhi, Scutellaria, Ginseng, Peony, and Ginger, 168g of Bupleurum, 87g of Pinellia, 42g of Licorice, 244g of Jujube, fully moisten with 8 times the amount of water, let it soak for 30 minutes, and heat to boil Afterwards, decoct for 30 minutes, filter with 3 layers of gauze while it is hot, add 6 times the amount of water to the filter residue and reflux to extract for 20 minutes, filter, combine the filtrate, concentrate to 750ml, and obtain a medicinal solution with a concentration of 1.14g / ml, and refrigerate for later use;

[0129] The preparation method of the freeze-dried powder of Bupleurum Guizhi Decoction: 10g of Bupleurum Guizhi Decoction refrigerated for later use; add 1.0g...

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Abstract

The present invention relates to the effect of Chaihu Guizhi Decoction combined with tigecycline in the treatment or prevention of pneumonia, especially the effect in the treatment of leukopenic Acinetobacter baumannii pneumonia, using a rat model of leukopenic Acinetobacter baumannii pneumonia, To provide reference for clinical treatment of Acinetobacter baumannii infection.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to the pharmaceutical application of Bupleurum Guizhi Decoction. Background technique [0002] In recent years, the problem of bacterial drug resistance has become increasingly serious. Acinetobacter baumannii, as one of the six "ESKAPE" multi-drug resistant bacteria, has a strong ability to acquire drug resistance and clone transmission. The elderly who are weak and have a low immune status Patients are prone to infection and develop drug resistance[1,2], which has become one of the most important pathogens for nosocomial infection in my country[3]. Western medicine treats bacterial infections mostly from the perspective of antibacterial, and uses a variety of antibiotics to kill and inhibit bacteria. However, the infection situation has not been completely controlled, and the problem of drug resistance is becoming more and more serious, which has certain limitations [4]. The t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P11/00A61P31/04A61K31/65
CPCA61K31/65A61K36/233A61K36/258A61K36/484A61K36/539A61K36/54A61K36/65A61K36/71A61K36/725A61K36/8888A61K36/9068A61P11/00A61P31/04A61K2300/00
Inventor 马致洁章从恩于小红赵奎君
Owner BEIJING FRIENDSHIP HOSPITAL CAPITAL MEDICAL UNIV
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