Functional near-infrared cerebral function imaging system using high-low dual density optrode configuration

An imaging system and double-density technology, applied in the direction of using spectral diagnosis, application, medical imaging, etc., can solve problems such as error and fNIRS signal interference, and achieve the effect of easy implementation and improved signal quality

Inactive Publication Date: 2018-08-31
SOUTHEAST UNIV
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Problems solved by technology

[0004] The purpose of the present invention is to address the above-mentioned deficiencies in the background technology, to provide a functional near-infrared brain functional imaging system that adopts a high-low double-density optode configuration, and eliminates the superficial tissue fNIRS signal in the fNIRS signal, and solves the existing problem. The fNIRS system has a large error due to ignoring the fNIRS signal interference in the superficial tissue

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  • Functional near-infrared cerebral function imaging system using high-low dual density optrode configuration
  • Functional near-infrared cerebral function imaging system using high-low dual density optrode configuration
  • Functional near-infrared cerebral function imaging system using high-low dual density optrode configuration

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[0021] The technical solutions of the invention will be described in detail below with reference to the accompanying drawings.

[0022] Near-infrared light can reach a certain depth of biological tissue, and this optical property is biologically determined by the turbid medium composed of biological macromolecules (such as hemoglobin) and water molecules. Physiological tissue has two responses to light, one is absorption and the other is scattering. The main components of blood (water, Oxy-Hb and Deoxy-Hb) absorb very little near-infrared light at 600-900 nm and have good scattering, so the near-infrared light of 600-900 nm is also called spectrum windows (such as figure 1 shown). The study found that within this spectral window, two hemoglobins, Oxy-Hb and Deoxy-Hb, have an isoabsorption point near 805 nm, such as figure 1 shown. On both sides of 805 nm, the two hemoglobins show their respective comparatively dominant absorption characteristics, so it is manifested as the...

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Abstract

The invention discloses a functional near-infrared cerebral function imaging system using high-low dual density optrode configuration, and belongs to the crossed technical field of bioimaging and information processing. The system comprises at least an emitting electrode configured on the surface of a brain, a receiving electrode configured on a brain surface and forming a low-density fNIRS channel with the emitting electrode, a receiving electrode configured on the brain surface and forming a high-density fNIRS channel with the emitting electrode in the low-density fNIRS channel, and a signalprocessor. Through independent component analysis and correlation analysis on the acquired fNIRS signals, independent components representing superficial tissue fNIRS signals in the fNIRS signals areremoved, so that the superficial tissue fNIRS signals included in an existing fNIRS system are effectively separated and removed. The system can obtain fNIRS signals which actually reflect cerebral cortex neural activities, and improves signal quality of an fNIRS system.

Description

technical field [0001] The invention discloses a functional near-infrared brain functional imaging system adopting a high-low dual-density optode configuration, which belongs to the technical field of the intersection of biological imaging and information processing. Background technique [0002] Near-infrared light can reach biological tissues at a certain depth. The main components of blood are water, oxygenated hemoglobin (Oxy-Hb) and deoxyhemoglobin (Deoxy-Hb). The absorption of near-infrared light at 600-900 nm is very small and Has good scattering properties. The process of brain neural activity will cause the relative increase of local Oxy-Hb concentration and the relative decrease of Deoxy-Hb concentration in a short time, and the changes of Oxy-Hb and Deoxy-Hb concentrations will lead to changes in the optical properties of brain tissue. By irradiating the brain with near-infrared light, the changes in the concentration of Oxy-Hb and Deoxy-Hb in the local cerebral ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00A61B5/1455
CPCA61B5/0075A61B5/14553A61B2576/026
Inventor 葛盛江一川刘慧
Owner SOUTHEAST UNIV
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