23 results about "Optode" patented technology

A self-calibrating hybrid spectrophotometer comprises a receptacle for receiving the cuvette, first and second optodes that are configured to permit light to enter the cuvette, third and fourth optodes that are configured to permit light to leave the cuvette, and a controller that is configured to control delivery of light to one of the first and second optodes. Light entering one of the first and second optodes is received at the third and fourth optodes after having interacted with the turbid sample along different paths having different lengths. Measurements made at the third and fourth optodes in response to having illuminated both the first and second source optodes provide two slopes of optical transmittance as a function of path length. The spectrophotometer uses these slopes to identify a slope that is indicative of the absorption coefficient and the reduced scattering coefficient of the sample.

A system for applying functional near infra-red spectroscopy (fNIRS) measurements to the head of a subject, is presented. The system comprising one or more of: a plurality of mirror optrodes, comprising at least one optode capable of connecting to the subject's scalp through a reflector arrangement, wherein the reflector arrangement is attachable to the subject's scalp through a light scattering couplant to be applied to the scalp; sticker optrodes comprising an adhesive fdm with at least one optode embedded into the film, and at least one flexible patch with a flexible support structure which comprises one or more expanded emitter optodes at the upper part of the flexible support structure, and wherein optrodes embedded into the lower part of the flexible support structure are non-expanded emitter and detector optodes. The sticker optrodes and flexible patch are configured to be attached to a hairless area on the subject's head.

An in-situ chemical imaging method and system applied to a soil drilosphere. The method comprises: S1, preparing an earthworm burrowing box and filling same with soil; S2, selecting appropriate earthworms and placing same in the soil for culturing, such that sufficient earthworm pores are generated in the soil; S3, sequentially providing a filter membrane (9), a DGT adsorption membrane (107) and a pH planar optode membrane (106) on a soil profile of a drilosphere which needs to be imaged, such that the three membranes can all be fully attached to the soil profile of the drilosphere, applying ultraviolet light under dark conditions, culturing for a period of time, and capturing a fluorescence signal emitted by the pH planar optode membrane (106), so as to obtain a pH fluorescence image; S4, performing color development on the DGT adsorption membrane (107); and S5, capturing a color-developed image of the DGT adsorption membrane (107) to obtain a DGT image, and performing picture processing on the DGT image and the pH fluorescence image to obtain spatial distribution images of available phosphorus and pH in the drilosphere. The problem of difficulty in in-situ detection of a biogeochemical cycling process driven by earthworm activities in soil is solved.

The application provides a deep water sediment-water interface simulation experiment device, which comprises a pressure tank, a pressurized gas tank, a circulating water temperature control unit, a sampling tank, a releasing device and a planar light pole unit; the pressurized tank and the sampling tank are connected with the pressure tank, and the sampling tank is used for sampling and sampling; the water inlet and the water outlet of the circulating water temperature control unit are connected with the two sides of the pressure tank; the releasing device and the planar light pole unit are arranged in the pressure tank, the releasing device is used for releasing the sampling device, and the planar light pole unit is used for emitting a fluorescent signal. The application can simulate the hydrostatic pressure, the dissolved oxygen level, the temperature and other related physical and chemical parameters of the water bottom sediment-water interface within 90m, and can reduce the limitation and economic pressure faced by the environmental in-situ monitoring.

An exemplary system comprises a memory that stores instructions and a processor communicatively coupled to the memory and configured to execute the instructions to perform a process. The process may comprise directing a cochlear implant to emit light having a first wavelength by way of one or more optrodes of an optrode lead inserted at least partially within a cochlea of a recipient, the light having a first wavelength optically stimulating neurons of the cochlea and directing the cochlear implant to emit light having a second wavelength by way of the one or more optrodes, the second wavelength being different than the first wavelength and triggering release of a compound that is impregnated within the optrode lead and that facilitates light sensitivity of the neurons.

A test kit (110), a test strip (112) and a method for determining analytes in a sample of a bodily fluid (111) are disclosed. The test kit (110) comprises: i) at least one test strip (112) comprising at least one membrane (114), wherein the membrane (114) comprises at least one first test field (116), the first test field (116) comprising at least one first capture component (118), wherein the membrane (114) further comprises at least one second test field (120), the second test field (120) comprising at least one second capture component (122), wherein the second capture component (122) is different from the first capture component (118); and ii) at least one first analyte detection system (124) for contacting with the sample of the bodily fluid (111), wherein the first analyte detection system (124) comprises at least one optode compound configured for receiving a first analyte suspected to be present in the sample of the bodily fluid (111), wherein the first analyte detection system (124) further comprises at least one first capture reagent; wherein the first capture component (118) is configured for capturing the first capture reagent of the first analyte detection system (124), wherein the second capture component (122) is configured for capturing at least one second capture reagent (136) from at least one second analyte detection system (126), the second capture reagent (136) being different from the first capture reagent.

The present invention provides a PET attenuation correction method and system for a five-modality integrated brain imaging device, relating to the field of brain imaging technology. The method comprises: generating a first attenuation coefficient map for a fixed-position hardware component; generating a second attenuation coefficient map for the optode and optical fiber of a non-fixed-position functional near-infrared spectrometer; superimposing the first attenuation coefficient map with the second attenuation coefficient map to generate a third attenuation coefficient map of the PET image under scanning conditions; and performing registration and attenuation correction on the third attenuation coefficient map to obtain an attenuation-corrected PET image. The present invention can more accurately obtain an attenuation template under each actual acquisition environment, and maximizes the correction of the effects of hardware components in the imaging field of view on the attenuation and scattering of gamma photons in PET imaging.

Hydrocarbon enhanced ionophore-based ion-selective optodes (ISOs) and methods of their use are provided. The ISOs exhibit improved ultrasensitive ion sensing due to the addition of ultralow-polarity hydrocarbons to the sensing phase using specific ratios of sensing phase components. The ISOs can be operated under an exhaustive or non-exhaustive extraction response mode.

Hydrocarbon enhanced ionophore-based ion-selective optodes (ISOs) and methods of their use are provided. The ISOs exhibit improved ultrasensitive ion sensing due to the addition of ultralow-polarity hydrocarbons to the sensing phase using specific ratios of sensing phase components. The ISOs can be operated under an exhaustive or non-exhaustive extraction response mode.

The application belongs to the field of environmental micro-interface two-dimensional pH monitoring technology, and discloses a planar optical electrode fluorescence sensing film with an acidic pH response range, a preparation method and application. Specifically, the application provides a pH-sensitive fluorescent indicator, the pH-sensitive fluorescent indicator is 2', 7'-dihalo-5(6)-N-octadecyl carboxamide fluorescein or 2', 4', 5', 7'-tetrahalo-5(6)-N-octadecyl carboxamide fluorescein, the molecular structural formula of the pH fluorescent indicator is shown as formula I; in the formula, X is selected from Cl or F; Y is selected from H, Cl or F; by introducing electron-withdrawing halogen atoms at the halogenated sites of fluorescein, the pKa value of the indicator is reduced, and the deficiency that the traditional planar optical electrode sensing film does not cover the acidic region is solved, wherein the tetrachloro derivative can realize the response in the strong acid interval of pH 1.70~4.96, and the tetrafluoro derivative can cover the acid-base interval of pH 2.75~7.68.

A portable two-mode probe to be applied against a biological tissue to be examined, the probe including an ultrasonic transducer configured to emit ultrasonic waves into the tissue and to receive ultrasonic waves reflected by the tissue, the transducer extending along a transverse axis; and at least two optodes placed on either side of the transverse axis, such that the transducer extends between the two optodes. Further, each optode includes a casing containing a light emitter configured to emit a light wave toward the tissue, and / or an optical detector configured to detect a light wave scattered by the tissue. The optodes are arranged such that at least one light emitter and at least one optical detector are placed on either side of the transducer, and at least one optical detector has a detection area formed from a semiconductor and connected to a circuit board.

Method for determining an amount of lithium contained in a biological fluid, said method comprising the steps consisting in adding, to a biological fluid sample of known volume, a given volume of a discriminating solution, the effect of which is to obtain a biological fluid solution buffered at a pH of between 6 and 8 and to bring about precipitation of at least a portion of the cations contained in the biological fluid sample except for the lithium ions. The method further comprises the steps consisting in depositing a given volume of biological fluid solution on an active layer (2) of an optode (1), said active layer comprising a chemical transducer of which at least one optical property is modified in the presence of lithium ions in the biological fluid solution, in measuring at least one characteristic of at least one light wave emitted or reflected by the active layer of the optode and in determining, from the at least one measured characteristic and from calibration data, an amount of lithium contained in the biological fluid.

A monitoring device (1) comprises a microwell plate (10) comprising microwells (20) dimensioned to hold a respective biological entity and a channel plate (30) comprising at least one fluid channel (40, 42) in fluid connection with a fluid input port (11; 11A, 11B) and a fluid output port (13; 13A, 13B). An optode composition (25) is present in the microwells (20) and comprising an analyte-sensitive optode compound generating a detectable optical signal in response to an analyte. The channel plate (30) and the microwell plate (10) are slidably arranged together and movable relative to each other between a loading position, in which the at least one fluid channel (40, 42) is in fluid connection with at least a subset (21, 23) of the plurality of microwells (25), and a monitoring position, in which the channel plate (30) closes the at least a subset (21, 23) of the plurality of microwells (20).

The present application relates to the field of computers and discloses a method, device, equipment and storage medium for monitoring brain blood oxygen response. The method includes obtaining a magnetic resonance image of the subject's brain and performing structural extraction to obtain a skull contour; constructing a three-dimensional optode helmet body for fitting the skull contour, and setting a high-density optode plug position on the target brain area of ​​the three-dimensional optode helmet body, and then using 3D printing technology to print the optode cap; respectively obtaining the three-dimensional coordinates of each position in the high-density optode and the target brain area, and determining the mapping relationship between the two by using a diffuse optical tomography method; obtaining and monitoring the blood oxygen response signal at each position in the target brain area by using the high-density optode. The embodiment of the present application realizes the individualization of blood oxygen response signal acquisition based on the personalized optode cap constructed based on the brain tissue of the subject, thereby improving the spatial positioning of the target brain area and the acquisition accuracy of its blood oxygen response signal.

The invention discloses a brain magnetic compatible near-infrared channel arrangement and modulation frequency distribution method, and belongs to the technical field of multi-mode brain function imaging. In order to solve the problems that in the prior art, personalized optrode arrangement optimization is difficult, standardized meta-information files are tedious to generate, and brain magnetic compatible frequency distribution efficiency is low, optrode coordinates are constructed based on individual head three-dimensional information, the positions of a light source and a detector are optimized through a greedy algorithm, and optrode two-dimensional coordinates are adjusted through dimension reduction and nonlinear optimization; and an automatic scheme is generated by using a method for carrying out brain magnetic compatible frequency allocation by using a graph coloring algorithm. According to the method, the experimental channel scheme of the whole brain or the region of interest can be quickly generated, the standard file and the channel visualization graph can be automatically generated, the brain magnetic compatibility and the high frequency utilization rate are considered at the same time, and the method is suitable for multi-mode brain imaging experiment preparation and personalized helmet or flexible cap optrode design.

A hair manipulation mechanism for use with an optrode of a functional near-infrared spectroscopy (fNIRS) system. The hair manipulation mechanism including a body defining a central axis, and a plurality of comb elements. Where each comb element includes at least one leg extending therefrom that is configured to engage the one or more hairs of the entity, and where each comb element of the plurality of comb elements is adjustable between a first position, in which the comb element is spaced a first radial distance from the central axis, and a second, position, in which the comb element is spaced a second radial distance from the central axis greater than the first distance.

The invention provides a PET attenuation correction method and system for five-mode integrated brain imaging equipment, and relates to the technical field of brain imaging. The method comprises the following steps: generating a first attenuation coefficient graph for a hardware component with a fixed position; generating a second attenuation coefficient map for the optrode and the optical fiber of the functional near-infrared spectrometer with the unfixed position; superposing the first attenuation coefficient graph and the second attenuation coefficient graph to generate a real third attenuation coefficient graph of the PET image under the scanning condition; and carrying out registration and attenuation correction on the third attenuation coefficient graph to obtain a PET image subjected to attenuation correction. According to the method, the attenuation template in each real acquisition environment can be more accurately obtained, and the influence of hardware parts in an imaging view on gamma photon attenuation and scattering in PET imaging is corrected to the greatest extent.

The application discloses a new-born brain function evaluation and neural development prognosis prediction system, relates to the technical field of new-born brain function evaluation, and comprises an EEG electrode module, an fNIRS optical electrode module and a prediction module. The EEG electrode module is used for collecting EEG signals of a new-born in real time within a set time period. The fNIRS optical electrode module is used for collecting rSO2 signals of the new-born in real time within the set time period. The prediction module is used for performing signal preprocessing on EEG signals of the whole brain of the new-born and the rSO2 signals of the new-born, obtaining preprocessed EEG signals and preprocessed rSO2 signals, generating a dynamic brain function connection network sequence capable of representing the time evolution characteristics of brain function connection structures by using the preprocessed EEG signals and the preprocessed rSO2 signals, obtaining a time-varying feature vector by using the dynamic brain function connection network sequence, and obtaining a prediction result of new-born brain function evaluation and neural development prognosis based on the time-varying feature vector and a prediction model established in advance.

The present invention relates to a mounting assembly for an optode and a head-mounted apparatus for a near-infrared brain function imaging device. The mounting assembly comprises: a first snap fit member, a second snap fit member, and a hood. The first snap fit member detachably engages the second snap fit member from a first side, and together with the second snap fit member, forms an accommodation cavity at least configured for accommodating the optode. The hood is slidably arranged in the accommodation cavity, and comprises a body for covering the optode. When the body is located at a first position, the outer wall of the body abuts against the inner wall of the lower edge of the first snap fit member. When the body is driven by a force to move in a first direction away from the first position, the outer wall of the body is displaced from the lower edge of the first snap fit member, and the first snap fit member can be deformed by a force, such that the first snap fit member can be detached from and attached to the second snap fit member. The above structure ensures the firm mounting of the optode, and avoids the problems of unfirm fixation and detachment of the optode due to unstable connection of the first snap fit member and the second snap fit member.

A cognitive load estimation system. The system includes an-in ear device (IED) configured to be placed within an ear canal of a user. The IED includes a first set of functional near-infrared spectroscopy (fNIRS) optodes that are configured to capture first fNIRS signal data representing hemodynamic changes in a brain of the user. The system further includes at least one electroencephalography (EEG) electrode configured to capture electrical signals corresponding to brain activity of the user. The system further includes a controller configured to filter the first fNIRS signal data based in part on the electrical signals to generate filtered fNIRS signal data. The controller is further configured to estimate a cognitive load of the user based on the filtered fNIRS signal data.

This invention discloses a method and system for calculating brain region blood flow based on time-frequency near-infrared brain imaging, belonging to the field of healthcare informatics technology. It converts light intensity data obtained from time-frequency near-infrared brain imaging into electrical data, and calculates and post-processes the electrical data using a modified Lambert-Beer law to generate a relative blood flow distribution chromatogram of the brain region under test. Simultaneously with the calculation and generation of the relative blood flow distribution chromatogram, a mental health assessment is conducted on the subject, and the relative blood flow distribution chromatogram is used to assist in evaluating the subject's mental health assessment results. This invention employs a novel multi-ring regular hexagonal honeycomb mesh structure construction method and sets a corresponding optical pole arrangement, significantly increasing the number of effective channels for calculation per unit area. Based on the modified Lambert-Beer law, it considers individual influencing factors, making the information expressed by the generated relative blood flow distribution chromatogram more accurate and comprehensive.

An exemplary optical cochlear implant assembly adapted for insertion into a recipient may comprise an optrode lead configured to be inserted at least partially within a cochlea of the recipient. The optrode lead may include a plurality of optrodes and an elastomeric encapsulant that encapsulates the plurality of optrodes and that includes one or more portions impregnated with a compound that facilitates light sensitivity of neurons of the cochlea. The optical cochlear implant assembly may further include an implantable cochlear stimulator (ICS) configured to deliver optical stimulation to the recipient by way of one or more optrodes included in the plurality of optrodes.