Pyrazolo[1,5a]pyrimidine derivatives as modulators of IRAK4

A technology of compounds and medicinal salts, applied in the field of compounds that inhibit interleukin-1 receptor-related kinase 4, can solve the problems of defective production of cytokines, increased susceptibility to infection, etc.
CN108473498BInactive Publication Date: 2021-11-02F HOFFMANN LA ROCHE & CO AG
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
F HOFFMANN LA ROCHE & CO AG
Publication Date
2021-11-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

Described herein are compounds of formula (0), formula (I) and formula (II) and methods of use as interleukin-1 receptor-associated kinase (IRAK4) inhibitors.
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Description

[0001] Cross References to Related Applications

[0002] This application claims U.S. Provisional Application No. 62 / 271,171, filed December 22, 2015, U.S. Provisional Application No. 62 / 279,459, filed January 15, 2016, and U.S. Provisional Application No. 62 / 279,459, filed September 22, 2016. 62 / 398,341 interests.

[0003] field of invention

[0004] The present invention relates to compounds useful for inhibiting interleukin-1 receptor-associated kinase 4 (IRAK4).

[0005] Background of the invention

[0006] Cell surface receptors containing TIR-domain (Toll-Interleukin 1 receptor-domain) such as Toll-like receptor (TLR) and IL-1 and IL-18 receptors play a key role in innate immunity, And it is related to the pathogenesis of autoimmunity. For example, TLRs recognize pathogenic or endogenous ligands and provide the necessary signals for dendritic cell maturation and antigen presentation to T cells. Similarly, proteins that mediate signaling by these receptors have also be...

Claims

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