Method for extracting levodopa by taking mucuna cochinchine-sis(Lour)Tang et Wang as raw material

A technology of levodopa and cat beans, which is applied in the field of agricultural product processing, can solve the problems of high depreciation rate, reduced permeability, and low product yield, and achieve the effects of improving product quality, reducing solution viscosity, and high product yield

Inactive Publication Date: 2018-09-18
那坡康正天然植物提取有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Each of the above technologies has its own advantages and disadvantages. Generally speaking, the technology of extracting levodopa from cat beans still has a lot of room for improvement
Some have high anti-corrosion requirements for equipment, short service life of equipment, high depreciation rate, some products produced are not high in purity, quality is not good enough, there are many impurities, product yield is low, product content is low, etc.; It takes a long time, and a large amount of inorganic salts and other substances are added in the preparation process, which may easily...

Method used

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  • Method for extracting levodopa by taking mucuna cochinchine-sis(Lour)Tang et Wang as raw material
  • Method for extracting levodopa by taking mucuna cochinchine-sis(Lour)Tang et Wang as raw material
  • Method for extracting levodopa by taking mucuna cochinchine-sis(Lour)Tang et Wang as raw material

Examples

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Effect test

Embodiment 1

[0050] A method for extracting levodopa from cat beans, comprising the following steps:

[0051] (1) Raw material pretreatment: the cat beans after removing impurities and washing are dried, crushed and set aside;

[0052] (2) Extraction: Add the pretreated cat beans to the extraction equipment, add acid solution 10 times its total weight, adjust the pH to 5.5, extract at 75°C and at a pressure of 0.5MPa, extract for 3 hours, and filter to obtain the extract ;

[0053](3) Impurity removal: add 8 times of its total weight to the obtained extract solution as a 60% ethanol solution, let it stand for 1.0 hour, reclaim the ethanol, and remove the alcohol-soluble impurities in the extract solution; then add lye to adjust pH4.5, precipitated water-soluble impurities, filtered to obtain the filtrate;

[0054] (4) Concentration: Evaporate and concentrate the filtrate to 10% of the original volume, precipitate crystals and filter to obtain the crude product of levodopa, the content of...

Embodiment 2

[0062] A method for extracting levodopa from cat beans, comprising the following steps:

[0063] (1) Raw material pretreatment: the cat beans after removing impurities and washing are dried, crushed and set aside;

[0064] (2) Extraction: Add the pretreated cat beans to the extraction equipment, add acid solution 12 times its total weight, adjust the pH to 5, extract at 75°C at a pressure of 0.5MPa, extract for 3 hours, and filter to obtain the extract ;

[0065] (3) Impurity removal: Add 5 to 10 times the total weight of the ethanol solution with a volume concentration of 60% to the obtained extract, let it stand for 1.0 hour, recover the ethanol, and remove the alcohol-soluble impurities in the extract; then add alkali The liquid is adjusted to pH 4.5, and water-soluble impurities are separated out, and the filtrate is obtained by filtration;

[0066] (4) Concentration: Evaporate and concentrate the filtrate to 12% of the original volume, precipitate crystals and filter to...

Embodiment 3

[0074] A method for extracting levodopa from cat beans, comprising the following steps:

[0075] (1) Raw material pretreatment: the cat beans after removing impurities and washing are dried, crushed and set aside;

[0076] (2) Extraction: Add the pretreated cat beans to the extraction equipment, add acid solution 12 times its total weight, adjust the pH to 5, extract at 75°C at a pressure of 0.5MPa, extract for 3 hours, and filter to obtain the extract ;

[0077] (3) Impurity removal: Add 5 to 10 times the total weight of the ethanol solution with a volume concentration of 60% to the obtained extract, let it stand for 0.8 hours, recycle the ethanol, and remove the alcohol-soluble impurities in the extract; then add alkali The pH of the liquid is adjusted to 4.6, and the water-soluble impurities are separated out, and the filtrate is obtained by filtration;

[0078] (4) Concentration: Evaporate and concentrate the filtrate to 10% of the original volume, precipitate crystals a...

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Abstract

The invention discloses a method for extracting levodopa by taking mucuna cochinchine-sis(Lour)Tang et Wang as a raw material. The method comprises the following steps: (1) raw material pretreatment,(2) extraction, (3) impurity removal, (4) concentration, (5) purification, (6) recrystallization, and (7) drying to obtain a product. According to the method for extracting the levodopa from the mucuna cochinchine-sis(Lour)Tang et Wang as the raw material, an acid solution adopts a mixed acid prepared from formic acid and hydrochloric acid according to a volume ratio of 1:(1 to 3), and can converttyrosine into dopa, thus greatly reducing the content of the tyrosine in the product, and improving the quality of the product; resin is not needed in a preparation process, and generated sewage andwastewater are less and easy to treat. The finished levodopa prepared by the method is high in yield, the crude product yield is 4.0-4.5 percent, the product yield is 2.8-3.0 percent, and the contentof the tyrosine in the prepared finished levodopa is reduced to 0.08 to 0.15 percent, and is reduced by 2 to 5 times compared with levodopa produced according to a conventional process.

Description

technical field [0001] The invention relates to the technical field of agricultural product processing, in particular to a method for extracting levodopa from cat beans. Background technique [0002] Cat bean, Latin scientific name Mucuna cochinchine-sis (Lour) Tang et Wang, also known as Li bean, dragon's claw bean, tiger's claw bean, dog's claw bean, cat's cat bean, leguminous bean is an annual herbaceous vine. Cylindrical stem, vines 2-10m long, multi-branched, three compound leaves, oblong-oval leaflets, racemes, butterfly-shaped corolla, nearly white or purple, is a drought-tolerant and adaptable crop , There are many rhizobia in the root, which can improve the fertility of the soil, the root system is relatively developed, the leaves and tendrils climb high, and the coverage is wide, which is conducive to maintaining water and soil. Native to southern and eastern Asia, China is mainly distributed in South China, Southwest China and Jiangxi, Hunan, Guangxi and other pr...

Claims

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Application Information

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IPC IPC(8): C07C229/36C07C227/40C07C227/42
CPCC07B2200/07C07C227/40C07C227/42C07C229/36
Inventor 陆华李学坚王玉玲黎永红刘布鸣黄艳柴玲
Owner 那坡康正天然植物提取有限责任公司
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