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Liquid crystal nanogel capsule for treating colon cancer and preparation method thereof

A technology of gel capsules and colon cancer, applied in the direction of capsule delivery, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve problems such as inconvenient taking, need to use syringes, and low drug dosage

Active Publication Date: 2021-05-11
EZHOU INST OF IND TECH HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the patent No. 201610294386.0 is an invention patent "a liposome composed of palmitoyl ascorbate and hydroxycamptothecin". The cumulative release of drugs in the plastids is not high, that is, the amount of drugs that have a real inhibitory effect on colon cancer cells is not high
Another example is the invention of patent No. 201510595966.9 "An injection preparation containing camptothecin derivatives, its injection, preparation and application", and the invention of patent No. 201110151869.2 "Gel buffer containing camptothecin or its derivatives release injection and its preparation method”, both of them adopt the injection method, need to use a syringe, use on occasion, take inconvenience, and the drug loading capacity of the injection preparation of the drug is not high

Method used

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  • Liquid crystal nanogel capsule for treating colon cancer and preparation method thereof
  • Liquid crystal nanogel capsule for treating colon cancer and preparation method thereof
  • Liquid crystal nanogel capsule for treating colon cancer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A liquid crystal nanogel capsule for the treatment of colon cancer provided in this embodiment comprises the following components by weight: 4% anticancer active ingredient, 11% poloxamer, 50% natural phospholipid, fatty acid glyceride 27.5%, co-solvent 7.5%;

[0026] The camptothecin, doxorubicin and docetaxel respectively account for 75%, 12.5% ​​and 12.5% ​​of the anticancer active ingredients by weight.

[0027] A kind of preparation method of liquid crystal nanogel capsule for the treatment of colon cancer provided by the present embodiment comprises the following steps:

[0028] S1. Weigh poloxamer, natural phospholipids, fatty acid glycerides, co-solvent, stir at 40°C until completely dissolved, stirring at 400rpm, stirring for 14min to obtain an oily mixed solution;

[0029] S2. Weighing the anti-cancer active ingredient, adding it to the mixed solution obtained in step S1, and dispersing it by ultrasonic waves at a temperature of 70° C. for 10 minutes, with an...

Embodiment 2

[0032] This example is basically the same as Example 1, except that a liquid crystal nanogel capsule for the treatment of colon cancer provided in this example includes the following components in proportion by weight: anticancer active ingredient 6%, Poloxamer 14%, natural phospholipid 40%, fatty acid glyceride 30%, co-solvent 10%.

Embodiment 3

[0034] This example is basically the same as Example 1, except that the liquid crystal nanogel capsule for the treatment of colon cancer provided in this example includes the following components in proportion by weight: anticancer active ingredient 2%, Poloxamer 8%, natural phospholipid 60%, fatty acid glyceride 25%, co-solvent 5%.

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Abstract

The invention discloses a liquid crystal nano-gel capsule for treating colon cancer. 60%, 25% to 30% of fatty acid glycerides, 5 to 10% of cosolvents, the anticancer active ingredients include camptothecin, and also include at least two of paclitaxel, docetaxel, and doxorubicin; and camptothecin by weight It accounts for 40% to 75% of the total amount of the anticancer active ingredients. The invention also provides a method for preparing a liquid crystal nanogel capsule for treating colon cancer. The other raw materials are first mixed, and then anticancer active ingredients are added for ultrasonic dispersion, and finally the liquid crystal gel precursor nano preparation is prepared. Freeze-dried powder is packed into capsule shells to make capsules. The invention maximizes the encapsulation rate and drug loading capacity of the liquid crystal gel, has high drug release degree, and has good targeting and anti-cancer effects.

Description

technical field [0001] The invention belongs to the field of liquid crystal nanogel capsule preparation, in particular to a liquid crystal nanogel capsule for treating colon cancer and a preparation method thereof. Background technique [0002] Due to people's work and rest time, irregular diet, and the influence of the living environment in modern society, human gastrointestinal organ cells have lesions and even cancers from time to time. Colon cancer is a common malignant tumor of the digestive tract that occurs in the colon. It occurs mostly at the junction of the rectum and the sigmoid colon. At present, the treatment of colon cancer is mainly based on surgery, supplemented by chemotherapy and drug therapy. [0003] Camptothecin, paclitaxel, docetaxel, and doxorubicin are common drugs used in the treatment of colon cancer. Camptothecin is a plant anticancer drug, which has good curative effect on gastrointestinal tract and head and neck cancer; paclitaxel is the best n...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K9/06A61K47/10A61K47/24A61K47/14A61K31/4745A61K31/337A61K31/704A61P35/00
CPCA61K9/06A61K9/4858A61K9/4866A61K31/337A61K31/4745A61K31/704A61P35/00A61K2300/00
Inventor 罗亮黄丽萍孟凡玲
Owner EZHOU INST OF IND TECH HUAZHONG UNIV OF SCI & TECH
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