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Pharmaceutical composition for treating keratitis of eyes

A composition and cornea technology, applied in the field of medicine, can solve the problems of large side effects and high risks of antibiotics, and achieve the effects of convenient use and good drug safety.

Inactive Publication Date: 2018-10-09
石永录
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, drugs and surgery are generally used to treat keratitis. Drug therapy mainly uses antibiotics, but there is no very satisfactory broad-spectrum antibacterial drug at present, and long-term use of antibiotics has serious side effects; , the risk of surgical treatment is relatively high

Method used

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  • Pharmaceutical composition for treating keratitis of eyes
  • Pharmaceutical composition for treating keratitis of eyes
  • Pharmaceutical composition for treating keratitis of eyes

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0019] The characterization of experimental example 1 medicine of the present invention

[0020]

[0021] 1 H-NMR (300MHz, DMSO-d 6 ):δ[ppm]=0.86(m,2H),1.02(m,2H),1.26(t,3H),1.75(m,1H),4.02(q,2H),5.34(d,2H),6.29 (d, 1H), 6.73 (br.d, 2H), 6.84 (br.s, 2H), 8.05 (d, 1H).

experiment example 2

[0022] The effect of experimental example 2 medicine treatment eye keratitis of the present invention

[0023] model building

[0024] New Zealand white rabbits were injected with 25% urethane into the ear vein (4mL / kg), and slowly pushed in. After the corneal reflex disappeared, the eyes were given 0.4% oxybucaine hydrochloride eye drops for surface anesthesia. Reference literature for model establishment (Yu Chunzhi. Replication of Rabbit Corneal Trauma and Scar Model [J]. Journal of Fourth Military Medical University. 1982(4): 342-345.). Put the rabbit into the fixed cylinder with only the head exposed. Clamp the central part of the titanium nail rod with vascular forceps, burn the nail head on the flame spray gun for 15 seconds, cool it at room temperature for 15 seconds, pull the third eyelid of the rabbit with fixed forceps, and place the nail head in the center of the cornea of ​​the rabbit eye. Perpendicular to the surface of the cornea of ​​the rabbit, lightly press...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating keratitis of the eyes. The pharmaceutical composition comprises a certain mass of an active medicinal component with a structure as described in the specification and other pharmaceutically-acceptable auxiliary additive components. The pharmaceutical composition of the invention is convenient to use and good in safety, has certain curative effect on keratitis, and provides a novel development direction for treatment of keratitis and a reliable basis for clinical application of drugs to treatment of corneal inflammations.

Description

technical field [0001] The invention relates to the field of medicine, in particular, the invention relates to a pharmaceutical composition for treating keratitis. Background technique [0002] Keratitis refers to corneal inflammatory lesions caused by trauma, or infection of bacteria, viruses, and fungi, including herpes simplex virus keratitis, superficial punctate keratitis, corneal degeneration, suppurative keratitis, keratitis, and fascicles Keratitis, etc. Corneal inflammation will inevitably affect vision more or less, especially if the inflammation invades the pupil area. A foreign body sensation, stinging or even burning sensation in the affected eye. Mixed hyperemia of the bulbar conjunctival surface with symptoms of photophobia, lacrimation, visual disturbance, and increased discharge. At present, drugs and surgery are generally used to treat keratitis. Drug therapy mainly uses antibiotics, but there is no very satisfactory broad-spectrum antibacterial drug at p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/506A61P27/02
CPCA61K31/506
Inventor 石永录
Owner 石永录