Gentamicin and vitamin B solid preparation for treating gastric diseases as well as preparation method and application of gentamicin and vitamin B solid preparation

A technology for solid preparation and stomach disease, applied in the field of medicine, can solve the problems of poor stability of vitamin B12, limited production capacity, unstable quality and the like, and achieve the effects of low production cost, improved safety and simple preparation method.

Inactive Publication Date: 2018-10-16
SHANGHAI SIXTH PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has been found in actual clinical applications that 240,000 IU gentamicin sulfate injection and 0.5 mg of vitamin B are added to 100 ml of compound vitamin B solution. 12 The method of injection still has the following defects: unstable quality, short shelf life, poor stability of vitamin B12, etc., and needs to be used now and prepared, and the production capacity is limited; therefore, for the above defects, it is necessary to further improve the existing compound preparations. Optimization and innovation

Method used

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  • Gentamicin and vitamin B solid preparation for treating gastric diseases as well as preparation method and application of gentamicin and vitamin B solid preparation
  • Gentamicin and vitamin B solid preparation for treating gastric diseases as well as preparation method and application of gentamicin and vitamin B solid preparation
  • Gentamicin and vitamin B solid preparation for treating gastric diseases as well as preparation method and application of gentamicin and vitamin B solid preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) The solid preparation of gentamicin B for the treatment of gastropathy comprises the following components:

[0027]

[0028] (2) according to the above-mentioned formula, the preparation method of the gentamicin B solid preparation for the treatment of gastropathy comprises the steps:

[0029] (1) Take by weighing gentamicin sulfate 3600g, vitamin B 12 11g, vitamin B 1 1200g, Vitamin B 2 450g, vitamin B 6 300g, talcum powder 1800g, starch 2000g, put in a V-shaped mixer and stir evenly at a speed of 15 rpm for 60 minutes;

[0030] (2) Take by weighing 49000g of starch, put in a V-type mixer, pour the mixture prepared in the above step (1), and stir evenly for 60 minutes at a rotating speed of 15 rpm;

[0031] (3) Granules are obtained by granulating the powder evenly mixed in step (2), or flattened to obtain tablets, or filled into capsules by an automatic capsule filling machine. The speed of the automatic capsule filling machine is 32 rpm. get capsules;

...

Embodiment 2

[0034] (1) The solid preparation of gentamicin B for the treatment of gastropathy comprises the following components:

[0035]

[0036]

[0037] (2) according to the above-mentioned formula, the preparation method of the gentamicin B solid preparation for the treatment of gastropathy comprises the steps:

[0038] (1) Take by weighing gentamicin sulfate 4200g, vitamin B 12 12g, vitamin B 1 900g, vitamin B 2 500g, Vitamin B 6 450g, talcum powder 1800g, starch 3000g, put in a V-type mixer and stir evenly, the speed is 15 rpm, and the time is 60 minutes;

[0039] (2) Take by weighing 46000g of starch, put in a V-type mixer, pour the mixture prepared in the above step (1), and stir evenly for 60 minutes at a rotating speed of 15 rpm;

[0040] (3) Granules are obtained by granulating the powder evenly mixed in step (2), or flattened to obtain tablets, or filled into capsules by an automatic capsule filling machine. The speed of the automatic capsule filling machine is 32 r...

Embodiment 3

[0043] (1) The solid preparation of gentamicin B for the treatment of gastropathy comprises the following components:

[0044]

[0045] (2) according to the above-mentioned formula, the preparation method of the gentamicin B solid preparation for the treatment of gastropathy comprises the steps:

[0046] (1) Weigh 4000g of gentamicin sulfate, vitamin B 12 10g, vitamin B 1 1000g, Vitamin B 2 400g, vitamin B 6 400g, talcum powder 2000g, starch 2000g, put in a V-shaped mixer and stir evenly at a speed of 15 rpm for 60 minutes;

[0047] (2) Take by weighing 48000g of starch, put it in a V-type mixer, pour the mixture prepared in the above step (1), and stir evenly for 60 minutes at a rotating speed of 15 rpm;

[0048] (3) Granules are obtained by granulating the powder evenly mixed in step (2), or flattened to obtain tablets, or filled into capsules by an automatic capsule filling machine. The speed of the automatic capsule filling machine is 32 rpm. get capsules;

[0049...

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Abstract

The invention discloses a gentamicin and vitamin B solid preparation for treating gastric diseases as well as a preparation method and application of the gentamicin and vitamin B solid preparation. The gentamicin and vitamin B solid preparation is prepared from the following components: 3800-4200g of gentamicin sulfate (by gentamicin), 8-12g of vitamin B12, 900-1200g of vitamin B1, 350-500g of vitamin B2, 300-450g of vitamin B6, 1800-2100g of talc powder and 49000-51000g of starch; the components can be totally prepared into 200,000 hollow gelatin capsules. By optimizing the compatibility andpreparation process of all the components, the prepared gentamicin and vitamin B solid preparation can continuously release medicines, provide a stable and long-lasting effective blood concentration and avoid or reduce a peak-to-valley phenomenon, so that the safety of medication use is better improved, and the adverse effects of the medicines are reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a gentamicin B solid preparation for treating stomach diseases, a preparation method and application thereof. Background technique [0002] For a long time, stomach disease has been a common and frequently occurring disease. With the increasing pressure of life and work, the proportion of people suffering from stomach disease is on the rise. The basic causes of stomach disease are cold, dampness, qi, blood and bacteria. Infection, Helicobacter pylori infection; Helicobacter pylori is closely related to active chronic gastritis, and is also related to peptic ulcer combined with active chronic gastritis. Its stomach disease is characterized by recurrent episodes, which will not heal for a long time, bringing pain and troubles to patients in different degrees, and even life-long troubles. Whether the disease is mild or severe, it will affect the patient's health to var...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7036A61K33/12A61K9/48A61K9/20A61K9/16A61K47/36A61P1/00A61P1/04A61P31/04A61K31/4415A61K31/51A61K31/525A61K31/714
CPCA61K9/0056A61K9/1652A61K9/2059A61K9/4866A61K31/4415A61K31/51A61K31/525A61K31/7036A61K31/714A61K33/12A61P1/00A61P1/04A61P31/04A61K2300/00
Inventor 郭澄
Owner SHANGHAI SIXTH PEOPLES HOSPITAL
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