Extraction technology for cucurbitacin D

An extraction process, cucurbitacin technology, applied in the direction of steroids, organic chemistry, etc., can solve the problems of insufficient extraction and high cost, and achieve the effects of low cost, improved extraction rate, and simple process

Inactive Publication Date: 2018-10-16
湖州展舒生物科技有限公司
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AI Technical Summary

Problems solved by technology

[0003] At present, when extracting cucurbitacin D from the fruit stem of Cucurbitaceae Melon genus muskm

Method used

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Embodiment Construction

[0013] The present invention will be described in further detail below through specific examples.

[0014] An extraction process of cucurbitacin D, comprising the following steps:

[0015] 1), the melon pedicle is sent into the pulverizer for pulverization, and the pulverized melon pedicle is obtained;

[0016] 2), carrying out twice ethanol reflux extraction on the pulverized melon pedicle, thereby obtaining the extract, the concentration of ethanol is 60-85%;

[0017] 3), the extract is concentrated and separated to obtain an ethyl acetate layer;

[0018] 4), and then concentrate the ethyl acetate layer to dryness, then add 10% pyridine and 30-50% ethanol, and reflux for 2.5-3.5 hours to separate and obtain cucurbitacin D.

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Abstract

The invention discloses an extraction technology for cucurbitacin D. The extraction technology comprises the following steps that 1) muskmelon pedicels are fed into a pulverizer to be pulverized so asto obtain pulverized muskmelon pedicels; 2) ethanol reflux extraction is carried out two times on the pulverized muskmelon pedicles so as to obtain an extracting solution; 3) the extracting solutionis concentrated and separated so as to obtain an ethyl acetate layer; and 4), then the ethyl acetate layer is concentrated to be dry, then 10% of pyridine and ethanol are added, refluxing is carried out for 2.5-3.5 h, and separating is carried out so as to obtain the cucurbitacin D. According to the extraction technology, 10% of pyridine and ethanol are adopted as weak base, a large amount of cucurbitacin B in the muskmelon pedicels is converted into the cucurbitacin D, separation and extraction are carried out, so that the extraction rate of the cucurbitacin D is greatly increased, in addition, the technology is simple, and the cost is low.

Description

technical field [0001] The invention relates to a process for extracting cucurbitacin D. Background technique [0002] The molecular formula of cucurbitacin D is C 30 h 44 o 7 , with a molecular weight of 516.67, white needle-like crystals at normal temperature and pressure, mainly derived from the fruit stem of Cucurbitaceae Melon, soluble in chloroform, slightly soluble in methanol, almost insoluble in water, relatively stable at room temperature Well, it needs to be stored in a cool place away from light. [0003] At present, when extracting cucurbitacin D from fruit stems of the genus Cucurbitaceae Melon, the extraction is not thorough enough, the cost is high, and the market demand cannot be met. Contents of the invention [0004] In view of the above problems, the present invention provides a process for extracting cucurbitacin D, which is simple, thorough and low in cost. [0005] The technical scheme adopted in the present invention is: [0006] An extraction...

Claims

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Application Information

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IPC IPC(8): C07J9/00
CPCC07J9/00
Inventor 吴建华
Owner 湖州展舒生物科技有限公司
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