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Application of cold sensory channel agonists in the preparation of drugs for promoting body's ability to adapt to cold

A sensory channel and agonist technology, applied in applications, drug combinations, pharmaceutical formulations, etc., can solve problems such as cognitive ability and fine manipulation ability decline, frostbite, affecting life and work, and achieve great social value and application prospects. Improvement of cold resistance, the effect of improving cold resistance

Active Publication Date: 2021-08-06
INST OF ENVIRONMENTAL MEDICINE & OCCUPATIONAL MEDICINE ACAD OF MILITARY MEDICINE ACAD OF MILITARY SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The cold environment threatens the health and working ability of the human body. It can cause cold injuries such as frostbite, hypothermia, dipped foot and trench foot, and can also promote the occurrence and development of hypertension, stroke, and various cancers. At the same time, it can also cause alertness. , cognitive ability and fine operation ability decline in different degrees of brain and body work ability, which seriously affects the life and work of people in the alpine environment

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  • Application of cold sensory channel agonists in the preparation of drugs for promoting body's ability to adapt to cold
  • Application of cold sensory channel agonists in the preparation of drugs for promoting body's ability to adapt to cold

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Embodiment Construction

[0014] The following are specific examples of the present invention to further describe the technical solutions of the present invention, but the present invention is not limited to these examples. Unless otherwise specified, the raw materials used in the examples of the present invention are commonly used raw materials in the art, and the methods used in the examples are conventional methods in the art.

[0015] The application of the cold sensory channel agonist of the present invention in the preparation of drugs for promoting the body's ability to adapt to cold, wherein the cold sensory channel agonist includes TRPM8 agonist and / or TRPA1 agonist. The TRPM8 agonist is selected from one or more of menthol, citral, linalool, eugenol and eucalyptol. The TRPA1 agonist is selected from one or more of cinnamaldehyde, mustard oil, allicin, capsaicin ester, carvacrol, eugenol, piperine, gingerol, wintergreen oil, clove oil, citral and menthol.

[0016] TRPM8 and TRPA1, as the body...

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Abstract

The invention belongs to the field of food and medicine, and relates to the application of a cold sensory channel agonist in promoting the body's ability to adapt to cold. Cold sensory channel agonists include TRPM8 agonists and / or TRPA1 agonists. The TRPM8 agonist is selected from one or more of menthol, citral, linalool, eugenol and eucalyptol. The TRPA1 agonist is selected from one or more of cinnamaldehyde, mustard oil, allicin, capsaicin ester, carvacrol, eugenol, piperine, gingerol, wintergreen oil, clove oil, citral and menthol.

Description

technical field [0001] The invention belongs to the field of food and medicine, and relates to the application of a cold sensory channel agonist in the preparation of a medicine for promoting the body's ability to adapt to cold. Background technique [0002] The transient receptor potential (TRP) channel is a kind of cation channel located on the cell membrane, which includes multiple members and is generally divided into seven subfamilies (TRPC, TRPA, TRPM, TRPV, TRPN, TRPP and TRPML). It is an important molecule for the body to sense external environmental stimuli. In the TRP family, TRPV subfamily members TRPV1, TRPV2, TRPV3, TRPV4, TRPM subfamily member TRPM8 and TRPA subfamily member TRPA1 ion channels are gated by voltage, while temperature and ligands can open and close the channels by changing the voltage The regulation of these subfamilies is therefore considered to be involved in temperature perception and temperature regulation. Among them, TRPM8 can sense the t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K45/00A61K31/045A61K31/11A61P43/00A23L33/10
CPCA23V2002/00A61K31/045A61K31/11A61K45/00A23L33/10A61P43/00A61K2300/00A23V2200/30
Inventor 杨丹凤李曦张永强张莉郭展
Owner INST OF ENVIRONMENTAL MEDICINE & OCCUPATIONAL MEDICINE ACAD OF MILITARY MEDICINE ACAD OF MILITARY SCI