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Application of compound turtle shell liver-softening tablet to preparation of medicine for treating acute liver injury

A technology for acute liver injury and compound turtle shell, which can be used in drug combinations, pharmaceutical formulations, plant raw materials, etc., and can solve the problems of single indication of compound turtle shell tablets and other problems

Inactive Publication Date: 2018-10-30
INNER MONGOLIA FURUI MEDICAL SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to solve the problem of single indication of Compound Biejia Ruangan Tablets at present, the present invention has carried out new research on the indications of Compound Biejia Ruangan Tablets

Method used

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  • Application of compound turtle shell liver-softening tablet to preparation of medicine for treating acute liver injury

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0022] Experimental example 1: Experiment of Compound Biejia Ruangan Tablets against Acute Liver Injury in Mice:

[0023] 1. Materials:

[0024] 1. Test product: Compound Biejia Ruangan Tablet raw material drug powder (Inner Mongolia Furui Medical Technology Co., Ltd.), each gram of powder is equivalent to 1.8545 grams of crude drug, batch number X20161205, provided by Inner Mongolia Furui Medical Technology Co., Ltd. or purchased from the market ; Bifendate (positive control drug), batch number 16100103, provided by Peking Union Medical College Pharmaceutical Factory.

[0025] During the test, the above-mentioned drugs were prepared into suspensions with required concentrations with 0.5% CMC-Na.

[0026] 2. Main reagents:

[0027] Carbon tetrachloride (batch number 20160108, Tianjin Yongda Chemical Reagent Co., Ltd.); CMC-Na (batch number 151204, Anhui Shanhe Pharmaceutical Excipients Co., Ltd.); ALT kit (batch number 140116024), AST kit (batch number 140216018), ALP kit...

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Abstract

The invention discloses application of a compound turtle shell liver-softening tablet to preparation of a medicine for treating acute liver injury, and belongs to the technical field of application oftraditional Chinese medicines. The compound turtle shell liver-softening tablet has the effects of reducing liver index increase and spleen index increase caused by the acute liver injury, reducing serum ALT and AST level increase caused by the acute liver injury, increasing sudden ALB drop caused by the acute injury, improving acute hepatocyte injury of a mouse, increasing the TP level, reducingthe T-Bil and ALP levels, increasing SOD and GSH-PX level decrease caused by the acute liver injury, reducing serum MDA content increase caused by the acute liver injury, improving pathological damage of a liver tissue of the mouse and the like. The invention has the advantages as follows: novel application of the compound turtle shell liver-softening tablet is provided, and a novel medicine choice is provided for treatment of the acute liver injury.

Description

technical field [0001] The invention belongs to the technical field of application of traditional Chinese medicines, and in particular relates to the application of compound Biejiaruangan tablets in the preparation of medicines for treating acute liver injury. Background technique [0002] Compound Biejia Ruangan Tablets are composed of eleven herbs including Biejia (made), Curcuma, Radix Paeoniae Rubra, Angelica, Sanqi, Codonopsis, Astragalus, Ziheche, Cordyceps, Radix Isatidis, and Forsythia. The exclusive variety of intellectual property rights is the first domestic drug for the prevention and treatment of chronic hepatitis B liver fibrosis and early liver cirrhosis, and has been selected into the national basic medical insurance drug list. At present, two patents have been authorized, a traditional Chinese medicine preparation for the treatment of chronic hepatitis B liver fibrosis and its preparation method (patent number: ZL00105695.6); design patent (patent number: ZL...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/20A61P1/16A61K35/586A61K35/50
CPCA61K9/20A61K35/50A61K35/586A61K36/068A61K36/195A61K36/232A61K36/258A61K36/315A61K36/344A61K36/481A61K36/634A61K36/65A61K36/71A61K36/9066A61P1/16A61K2300/00
Inventor 袁海龙王新红李寅超邓莉张娴勰刘园申宝德沈成英朱颖超
Owner INNER MONGOLIA FURUI MEDICAL SCI
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