Method for preparing phenol through efficient standard hydroxylation of phenylboronic acid
A technology of phenylboronic acid and hydroxylation, applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., can solve the problems of metal loss and cost increase, and achieve the effect of easy separation and high yield
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Embodiment 1
[0022] 5 mmol of phenylboronic acid, 5 mmol of sodium perborate and 5 mmol of additive sodium bicarbonate were added to the reactor with 10 mL of water. At 25°C, phenylboronic acid, sodium perborate and a weak base were dissolved in water, stirred and reacted at a certain temperature for 30 minutes, and then the reaction solution was acidified to pH 3-4, separated, and the yield of phenol was 92.3%.
Embodiment 2
[0024] 5 mmol of phenylboronic acid, 5 mmol of sodium perborate and 5 mmol of additive sodium bicarbonate were added to the reactor with 10 mL of methanol. At 25°C, phenylboronic acid and sodium perborate were dissolved in methanol, stirred and reacted at a certain temperature for 30 minutes, and then the reaction liquid was acidified to pH 3-4, separated, and the yield was 91.6%.
Embodiment 3
[0026] Add 5mmol of phenylboronic acid and 4mmol of sodium perborate into a reactor with 10mL of water, and react for 30min at 25°C. Then the reaction solution was acidified to pH 3-4 and separated to obtain a yield of 74.1%.
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