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Application of hydroxysafflor yellow b in the preparation of drugs for treating breast cancer

A technology of hydroxy safflower and yellow pigment, which can be applied in the direction of drug combination, pharmaceutical formula, antineoplastic drugs, etc., and can solve the problem that the specific application is blank

Active Publication Date: 2021-02-26
BINZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the academic reports of hydroxysafflower yellow A in cancer have also been mentioned, but the specific application of hydroxysafflower yellow B as a new extract in the treatment of breast cancer is still blank

Method used

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  • Application of hydroxysafflor yellow b in the preparation of drugs for treating breast cancer
  • Application of hydroxysafflor yellow b in the preparation of drugs for treating breast cancer
  • Application of hydroxysafflor yellow b in the preparation of drugs for treating breast cancer

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Experimental program
Comparison scheme
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Embodiment Construction

[0015] The present invention will be described in detail below in combination with specific embodiments.

[0016] The molecular formula of hydroxy safflower yellow pigment B of the present invention is C 27 h 32 o 16 , the molecular structure is as follows:

[0017]

[0018] 1,5-cyclohexadien-1-one, 4β-D-glucopyranosyl-6-α-D-fructopyran-3-4-5-trihydroxy-2-[(2e)-3( 4-Hydroxyphenyl)-1-oxo-2-propenyl]-(9CI).

[0019] 1. Experimental materials:

[0020] Experimental cells: breast cancer MCF-7 cells, using DMEM medium containing 10% FBS, 0.01mg / ml recombinant human insulin and 1% penicillin streptomycin, at 37°C, 5% CO 2 Cultured in a humidified incubator, digested and passaged with conventional trypsin EDTA.

[0021] Experimental Drug: Hydroxysafflower Yellow B

[0022] Other experimental materials: cryopreservation tubes, DMEM culture medium (Gibco), 0.01mol / L PBS buffer, 0.25% trypsin (Solarbio, T1320), fetal bovine serum (Sijiqing, 20171212), thiazole blue staining so...

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Abstract

The invention discloses application of hydroxysafflor yellow B to the preparation of drugs for treating breast cancer. The hydroxysafflor yellow B provided by the invention can induce breast cancer cell cycle arrest and promote breast cancer cell apoptosis, remarkably inhibiting the proliferation of breast cancer cells. The beneficial effect of the invention is proved for the first time that the hydroxysafflor yellow B can effectively inhibit the proliferation of the breast cancer cells, achieving the effect of treating breast cancer, and the hydroxysafflor yellow B can be used in antitumor researches for the preparation of thebreast cancer cell proliferation inhibition drugs or anti-breast cancer drugs.

Description

technical field [0001] The invention belongs to the technical field of drugs for treating tumors, and relates to the application of hydroxysafflower yellow B in the preparation of drugs for treating breast cancer. Background technique [0002] Breast cancer is one of the most common high-grade tumors in women. The global incidence of breast cancer has been on the rise since the late 1970s. Although the morbidity rate in China is lower than that in western countries, the morbidity and mortality rates are increasing year by year, especially in urban and rural areas, which poses a serious threat to women's health. And statistical data show that in recent years, the growth rate of the incidence of breast cancer in my country is 1 to 2 percentage points higher than that of Western high-incidence countries. Although surgical resection, adjuvant radiotherapy and chemotherapy are currently used clinically to treat breast cancer patients, and these treatments have also played a cer...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61P35/00A61P15/14
CPCA61K31/7048A61P15/14A61P35/00
Inventor 李德芳郑秋生曲传俊陈小宇刘晓娜叶蕾
Owner BINZHOU MEDICAL COLLEGE