A blood filter material for removing white blood cells and its preparation method

A technology of blood filtration and white blood cells, which is applied in separation methods, filtration separation, membrane filters, etc., can solve the problems of increased blood filtration time, poor safety of electrospinning technology, and influence on operating efficiency, so as to shorten blood filtration time and improve Blood wettability, effect of improving operation efficiency

Active Publication Date: 2021-02-09
DONGGUAN YIMAO FILTER MEDIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composite nonwoven material has the advantages of high porosity and large specific surface area, but the electrospinning technology has poor safety and low production efficiency, which is not conducive to industrial production, and the pure polybutylene terephthalate has poor hydrophilicity and blood The inability to fully flow in the filter medium is not conducive to the full utilization of the filter material, prolongs the blood filtration time, and affects the actual operating efficiency

Method used

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  • A blood filter material for removing white blood cells and its preparation method
  • A blood filter material for removing white blood cells and its preparation method

Examples

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Effect test

Embodiment 1

[0030] A blood filter material for removing leukocytes, the blood filter material includes a primary filter layer and a fine filter layer, the primary filter layer is a centrifugal spinning layer, the fine filter layer is a melt-blown layer, the primary filter layer is attached to the surface of the fine filter layer, Moreover, both the primary filter layer and the fine filter layer are polybutylene terephthalate / silk fibroin composite fibers.

[0031] The thickness of the fine filter layer is 0.05 mm, the diameter of the composite fiber used for the fine filter layer is 300 nm, and the pore size is 0.5 μm.

[0032] The thickness of the primary filter layer is 0.5mm, the diameter of the composite fiber used for the primary filter layer is 1 μm, and the pore size is 2 μm.

[0033] A preparation method for removing leukocyte blood filter material, said preparation method comprising the following steps:

[0034] a. Preparation of fine filter layer

[0035] After blending polybu...

Embodiment 2

[0043] A blood filter material for removing leukocytes, the blood filter material includes a primary filter layer and a fine filter layer, the primary filter layer is a centrifugal spinning layer, the fine filter layer is a melt-blown layer, the primary filter layer is attached to the surface of the fine filter layer, Moreover, both the primary filter layer and the fine filter layer are polybutylene terephthalate / silk fibroin composite fibers.

[0044] The thickness of the fine filter layer is 0.1 mm, the diameter of the composite fiber used for the fine filter layer is 1000 nm, and the pore size is 2 μm.

[0045] The thickness of the primary filter layer is 1 mm, the diameter of the composite fiber used for the primary filter layer is 3 μm, and the pore size is 5 μm.

[0046] A preparation method for removing leukocyte blood filter material, said preparation method comprising the following steps:

[0047] a. Preparation of fine filter layer

[0048] After blending polybutyl...

Embodiment 3

[0056] A blood filter material for removing leukocytes, the blood filter material includes a primary filter layer and a fine filter layer, the primary filter layer is a centrifugal spinning layer, the fine filter layer is a melt-blown layer, the primary filter layer is attached to the surface of the fine filter layer, Moreover, both the primary filter layer and the fine filter layer are polybutylene terephthalate / silk fibroin composite fibers.

[0057] The thickness of the fine filter layer is 0.2 mm, the diameter of the composite fiber used for the fine filter layer is 2000 nm, and the pore size is 3 μm.

[0058] The thickness of the primary filter layer is 1.5 mm, the diameter of the composite fiber used for the primary filter layer is 5 μm, and the pore size is 10 μm.

[0059] A preparation method for removing leukocyte blood filter material, said preparation method comprising the following steps:

[0060] a. Preparation of fine filter layer

[0061] After blending polybu...

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Abstract

The invention relates to a blood filter material for removing white blood cells and a preparation method thereof. The blood filter material includes a primary filter layer and a fine filter layer, and the preparation method includes preparation of the fine filter layer, preparation of centrifugal spinning solution, and preparation of the primary filter layer and post-treatment, in which the fine filter layer is made of polyester slices processed by melt-blown technology, the primary filter layer is made of polymers deposited on the fine filter layer through centrifugal spinning, and the primary filter layer and the fine filter layer are both Polybutylene terephthalate / silk fibroin composite fiber material is used. The blood filter material of the present invention has large specific surface area, high porosity, and gradient distribution of pore diameter, which greatly improves the clearance rate of leukocytes in blood; has good blood wettability, shortens blood filtration time; simple preparation method, low cost, It is easy to realize industrialized production.

Description

technical field [0001] The invention belongs to the field of composite non-woven materials and its preparation, in particular to a blood filter material for removing leukocytes and its preparation method. Background technique [0002] During medical blood transfusion, leukocytes often produce leukocyte antigen (HLA), which in turn triggers an alloimmune reaction: non-hemolytic febrile reaction accompanied by symptoms such as headache, vomiting, and high fever, which can even be life-threatening in severe cases. According to some studies, when the leukocyte content in the transfused blood is lower than 5×10 5 Individuals / ml can prevent HLA immune response. Therefore, it is necessary to perform leukocyte filtration before blood transfusion. [0003] At present, the methods used to remove leukocytes in blood at home and abroad mainly include centrifugation, freezing to remove glycerol, washing, ultraviolet irradiation and filtration, among which filtration is the most feasibl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D39/16D01F1/10D01F6/92A61M1/02A61M1/00
CPCA61M1/00A61M1/02B01D39/1607B01D2239/10D01F1/10D01F6/92
Inventor 王亚飞张科宋宝祥
Owner DONGGUAN YIMAO FILTER MEDIA
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