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Microfluidic chip, apparatus for enriching cells and method for enriching cells in a microfluidic chip

A microfluidic chip and cell technology, applied in the field of target enrichment, can solve the problems of high operating pressure, low selectivity, loss of function or feasibility of further analysis, etc., and achieve the effect of improving efficiency

Active Publication Date: 2018-11-23
MICAREO TAIWAN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, commercial cell sorters have several limitations for sorting rare cell populations, including generally low selectivity, significant sample loss, and high operating stress, which can lead to loss of function or viability for further analysis

Method used

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  • Microfluidic chip, apparatus for enriching cells and method for enriching cells in a microfluidic chip
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  • Microfluidic chip, apparatus for enriching cells and method for enriching cells in a microfluidic chip

Examples

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Embodiment Construction

[0032] figure 1 A perspective view schematically showing a part of a microfluidic chip according to an embodiment. refer to figure 1 , the microfluidic chip MFC may include a substrate SUB and a channel forming layer CFL. The channel forming layer CFL may be bonded to the substrate SUB through a plasma bonding process or other processes capable of firmly attaching the channel forming layer CFL to the substrate SUB. The channel-forming layer CFL may have a specific pattern, and the pattern of the channel-forming layer CFL defines one or more channels CH and one or more holes HL based on a desired design. The pattern defining the channel CH may be a concave pattern, and the channel forming layer CFL is bonded to the substrate SUB to form a sealed space at the channel CH, which allows fluid to travel therein. The pattern defining the hole HL may pass through the entire thickness of the channel-forming layer CFL, and one end of the hole HL may be exposed after the channel-formi...

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Abstract

In accordance with an embodiment, a microfluidic chip including a first cells enrichment system and a second cells enrichment system is provided. Channel layouts of the first and the second cells enrichment systems are symmetric with respect to a reflection plane vertical to the microfluidic chip. Each of the first the second cells enrichment systems includes a first fluid channel, a second fluidchannel, a sample channel, an inlet channel, and a filtration chamber. The sample channel of the first cells enrichment system has a first inner wall and a first outer wall. The sample channel of thesecond cells enrichment system has a second inner wall and a second outer wall. The first outer wall and the second outer wall are both far from the reflection plane. A distance between the first outer wall and the second outer wall is in the range from about 10[mu]m to about 1cm.

Description

technical field [0001] The present invention relates to techniques for enriching targets in fluid samples, and in particular, to a microfluidic chip, a device for enriching cells, and a method for enriching cells in a microfluidic chip. Background technique [0002] A microfluidic chip is a chip-like device with one or more microfluidic channels that allow a fluid sample and / or desired reagents to travel therein such that the fluid sample can be tested in the channels of the microfluidic chip. Microfluidic chips have been used in various fields, especially biologically related fields such as biomedicine, biochemistry, or related fields. In applications in bio-related fields, blood samples are tested in microfluidic chips. Blood samples often contain a variety of cells, and the need to sort rare cells is expanding rapidly. Rare target cell populations include circulating tumor cells (circulating tumor cells, CTCs), hematopoietic stem cells (hematopoietic stem cells, HSCs) a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/12C12M1/00
CPCC12M23/16C12M33/14B01L2200/0636B01L2200/0652B01L2300/0681B01L2300/0816B01L2300/0861B01L2400/0463G01N15/1459G01N2015/1006B01L3/502761G01N15/149G01N15/1023G01N2015/1028B01L2200/141C12M27/00
Inventor 游辉民钟文峰陈瑞麟
Owner MICAREO TAIWAN CO LTD
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