Vitamin E emulsion spray and preparation technology thereof

A preparation process and vitamin technology, applied in aerosol delivery, skin diseases, drug combination and other directions, can solve the problems of easy scabbing, poor stability of preparations, difficult to spread, etc., and achieve improved efficacy, good stability, and permeability. Good results

Inactive Publication Date: 2018-11-30
安徽艾尼生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the preparation process of vitamin E preparations for dry skin on the market is cream or ointment. This traditional formula and process is more irritating to the skin, easy to scab, greasy, poor

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0037] A vitamin E milk spray, the weight ratio between its raw material components is:

[0038] Vitamin E 1, absolute ethanol 10, glycerin 5, butylene glycol 1, polysorbate-80 0.6, sorbitan oleate 0.4, purified water 82.

[0039] The preparation technology of described a kind of vitamin E milk spray, carries out according to the following steps successively:

[0040] 1. Take polysorbate-80 and sorbitan oleate as the oil phase, mix polysorbate-80 and sorbitan oleate in proportion to form the oil phase; add vitamin E, butylene glycol and glycerin to the polysorbate Sorbitan-80 and sorbitan oleate are mixed in an oil phase, heated to an emulsification temperature of 80° C., and stirred evenly to obtain a mixture.

[0041] 2. Add purified water with a temperature of 80° C. into the mixture and stir evenly to obtain a microemulsion with a particle size of 60-100 nm.

[0042] 3. Add ethanol to the microemulsion obtained above, adjust the pH value to 6.7, and stir evenly to obtain...

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PUM

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Abstract

The invention discloses a vitamin E emulsion spray and preparation technology thereof. The vitamin E emulsion spray comprises the raw material components of, by weight ratio, 0.5-1.5% of vitamin E, 5-15% of absolute ethyl alcohol, 4-10% of glycerol, 0.5-5% of butanediol, 0.3-1% of polysorbate-80, 0.2-1% of sorbitan oleate and 20-100% of purified water. The preparation process comprises the steps that the vitamin E, the butanediol and the glycerol are added into an oil phase composed of the polysorbate-80 and the sorbitan oleate for mixing, and heating is performed to an emulsification temperature of 80 DEG C and then stirring is performed evenly to obtain a mixture; the purified water with a temperature of 80 DEG C is added into the mixture and uniform stirring is performed to obtain a micro emulsion with a particle size of 60-100nm; the ethyl alcohol is added into the micro emulsion, the pH value is adjusted to 6.7, uniform stirring is performed, and then the vitamin E emulsion sprayis obtained. The vitamin E emulsion spray has clear pharmacological action, good stability, remarkable effect and no toxic and side effects, and the use is convenient and safe.

Description

Technical field: [0001] The invention relates to the formula of Chinese and western medicine spray preparations, in particular to the formula of vitamin E emulsion spray and its preparation process. Background technique: [0002] Dry skin refers to a variety of uncomfortable symptoms such as skin tightness, dryness and peeling, redness, and itching caused by lack of moisture in the skin due to various reasons. It is a very common skin problem, and severe cases can lead to various skin diseases. The incidence of dry skin is as high as 70% in autumn and winter; in summer, the incidence also reaches 34%. [0003] At present, the preparation process of vitamin E preparations for dry skin on the market is cream or ointment. This traditional formula and process is more irritating to the skin, easy to scab, greasy, poor in permeability, and difficult to apply , not easy to absorb, after smearing, it not only affects the appearance, but also easily pollutes clothes, and the prepar...

Claims

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Application Information

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IPC IPC(8): A61K9/12A61K47/26A61K47/10A61K31/355A61P17/16A61P17/18A61P17/00
CPCA61K9/12A61K9/0014A61K31/355A61K47/10A61K47/26A61P17/00A61P17/16A61P17/18
Inventor 唐浩哲罗世梅
Owner 安徽艾尼生物科技有限公司
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