Application of star-flower lysimachia to preparation of medicine for enhancing immunity of blood system

A technology of blood system and wind-chasing umbrella, which is applied in the field of medicine, can solve the problems that the wind-chasing umbrella has not yet been discovered and affects the popularization and application of wind-chasing umbrellas

Inactive Publication Date: 2018-12-07
GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, most of the prescriptions use Umbrella frighteningly in combination with other components to treat the above diseases. There are few studies on the separation and identification of the extracted products of Umbrella Zhefeng and the mechanism at the molecular level. The report of the use has seriously affected the further popularization and application of wind chasing umbrellas

Method used

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  • Application of star-flower lysimachia to preparation of medicine for enhancing immunity of blood system
  • Application of star-flower lysimachia to preparation of medicine for enhancing immunity of blood system
  • Application of star-flower lysimachia to preparation of medicine for enhancing immunity of blood system

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Experimental program
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Effect test

preparation example Construction

[0021] 1. Preparation of the extract of Umbrella chasing wind

[0022] 2000 grams of chasing wind umbrella medicinal materials are crushed, and 10 times the quality of distilled water is used each time (that is, the quality of distilled water used each time is 20 kg), and the medicinal materials are reflux extracted for 2 hours by using the reflux extraction method, a total of 3 extractions, The extracts were combined, concentrated to 2 liters, and the concentrate was freeze-dried to obtain 253 grams of Umbrella chasing umbrella extract.

[0023] 2. Determination of the chromatographic profile of the umbrella extract

[0024] (1) Liquid phase conditions: Shimadzu ultra-high performance liquid chromatography 30A (Shimadzu Corporation, Japan), equipped with ACQUITY UPLCTMHSS T3 chromatographic column (100mm×2.1mm i.d., 1.8μm) (Waters Group Corporation, USA). Mobile phase A was distilled water (containing 0.1% formic acid, w / w), and mobile phase B was acetonitrile (containing 0....

Embodiment 1

[0053] Male SD rats were purchased from Speifu (Beijing) Biotechnology Co., Ltd., the number of male SD rats in the blank control group was 10, and the number of male SD rats in the Zhafeng umbrella low-dose group was 10. The number of male SD rats in the middle-dose group was 10, and the number of male SD rats in the high-dose group was 10. The dose of the extract of the extract of the umbrella in the low-dose group is 0.01-0.02g / kg each time, and the dose of the extract of the umbrella in the middle-dose group is 0.03-0.04g / kg each. The dosage of the extract of Zingfeng umbrella in the kg and Zhuifeng umbrella high-dose group is 0.05-0.06g / kg each time, orally administered once a day for 3 consecutive days. The blank control group was given the same amount of normal saline for 3 days, orally once a day.

Embodiment 2

[0055] Male SD rats were purchased from Speifu (Beijing) Biotechnology Co., Ltd., the number of male SD rats in the blank control group was 10, and the number of male SD rats in the Zhafeng umbrella low-dose group was 10. The number of male SD rats in the middle-dose group was 10, and the number of male SD rats in the high-dose group was 10. The dose of the extract of the extract of the umbrella in the low-dose group is 0.01-0.02g / kg each time, and the dose of the extract of the umbrella in the middle-dose group is 0.03-0.04g / kg each. The dosage of the extract of the umbrella in kg and the high dose group is 0.05-0.06g / kg each time, and it is administered orally once a day for 30 consecutive days. The blank control group was given the same amount of normal saline for 30 days, orally once a day.

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Abstract

The invention relates to application of star-flower lysimachia to preparation of a medicine for enhancing the immunity of a blood system. The inventor accidentally finds out that an expression level of a polymeric immunoglobulin receptor and cadherin-17 is remarkably up-regulated after the star-flower lysimachia is intervened from the researches. The polymeric immunoglobulin receptor has an immunity regulation function and plays a vital role in resistance of microorganism infection. The cadherin-17 plays a vital role in long-period survival of memory B cells, and can be used for resisting infection through increasing the durability of humoral immunity. An application range of the star-flower lysimachia can be further expanded and the star-flower lysimachia and extract thereof are used forpreventing and controlling various microorganism infected diseases.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of wind-chasing umbrellas in the preparation of medicines for enhancing blood system immunity. Background technique [0002] Chasing Wind Umbrella is the whole herb of Primulaceae plants with narrow leaves. Also known as, "Chasing Wind Umbrella" is also called "Mabi Wood". Mabimu is a Chinese herbal medicine that has the functions of expelling wind and dampness, regulating qi and dispelling cold. [0003] It is recorded in "Guizhou Folk Prescription Collection", "Guiyang Folk Herbs" and "Guizhou Herbal Medicine", and it is also called Jingfeng Umbrella, Yiyi Umbrella or Gongjiegudan. Perennial herb with narrow leaves, about 30 cm high. Plant form fibrous root light yellow. Stems tufted, unbranched, red near base, pilose. The upper part is green, the nodes are slightly enlarged, and there are short hairs. The leaves on the lower part of the stem ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P37/04A61P31/04
CPCA61K36/185A61K2236/331A61K2236/39A61K2236/51A61P31/04A61P37/04
Inventor 李煦照张帅男
Owner GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
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