Bionic duodenum and preparation method thereof

Abstract

The invention discloses a bionic duodenum and a preparation method thereof, and belongs to the technical fields of bionics and biology. The bionic duodenum is prepared by mixing a substrate (one or more of silica gel, latex or hydrogel) and auxiliary materials (silicone oil and / or a curing agent) according to a certain mass ratio and then smearing the mixed material into a precise human intestinaltract anatomical model duodenum of the medical digestive department. The bionic duodenum is excellent in simulated performance and is in the shape and physiological structure of the actual human duodenum, and can simulate the digestive environment in the human duodenum actually, for example, the inside of the bionic duodenum is provided with annular wrinkles, the superficial area in the intestinecan be increased, and microbial floras in the duodenum are allowed to better digest and absorb food. Meanwhile, the bionic duodenum is internally provided with intestinal villi, and the intestinal villi are of a hollow structure, intestinal juice can be secreted, and the function of digestion and absorption in the duodenum is greatly achieved again.

Description

technical field [0001] The invention relates to a bionic duodenum and a preparation method thereof, belonging to the field of bionic technology and the field of biotechnology. Background technique [0002] In the research process of food and medicine, it is very important to objectively and accurately evaluate the digestion process of food and medicine in the human body to determine the components of food and medicine and their effects on the human digestive tract. [0003] The human digestive tract in vitro simulation device (such as SHIME, IViDiS, TIM, DGM, HGS, etc.) is a device for bionic simulation of the human digestive system, its digestive environment, and the fluid dynamic behavior in the digestive tract. It can simulate different samples in an in vitro model. The digestive process of these samples and the influence of these samples on intestinal microorganisms provide a lot of valuable data for the research and development of new functional foods. If it is used as ...

AI Technical Summary

Problems solved by technology

[0007] However, the internal physiological structures of these existing digestive tract models made of silica gel and latex are smooth and single, such as small intestine models, and these small intestine models often have the following structural defects: one is that they do not have small intestinal villi, which makes the intestines The area in contact with food is too small, resulting in limited function of digestion and absorption in the small intestine; second, the intestinal juice is reflected in the form of direct addition, and the secretion of intestinal juice is uneven, resulting in inaccurate test results

[0008] Moreover, these digestive tract models are often simply made as a whole structure, for example, a whole stomach is molded with silicone or latex at one time, and these whole stomachs cannot simulate the "back jet" function between the gastric antrum and the gastric body, resulting in The experimental results are not accurate

[0009] At the same time, these digestive tract models made of silica gel and latex are not satisfactory in terms of simulation performance, such as hardness, expansion rate, and elasticity, and there is still a certain gap with the real digestive tract of humans.

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