Nitrating device and nitrating process and method for preparing o-nitrobenzaldehyde

Abstract

The invention discloses a nitrating device for preparing o-nitrobenzaldehyde. The nitrating device comprises a first flow pump, a pipeline I, a magnetic stirrer, a second flow pump, a pipeline II, a pipeline III, a spiral-pipe heat exchanger, a pipeline IV and a liquid storage tank, wherein the first flow pump is connected to the magnetic stirrer by the pipeline I; the second flow pump is connected to the magnetic stirrer by the pipeline II; the magnetic stirrer is connected to the spiral-pipe heat exchanger by the pipeline III; the spiral-pipe heat exchanger is connected to the liquid storagetank by the pipeline IV. The invention also discloses a nitrating process and method for preparing the o-nitrobenzaldehyde. The nitrating device and the nitrating process and method disclosed by theinvention has the advantages that the initial reaction speed is increased; continuous feeding is achieved; the reaction time is short, and the total amount of participated reaction materials is less;when the factors such as power failure, water supply shutdown and stirring stoppage and the like occur, since the total amount of reaction materials in a reaction device is less, no explosion risk iscaused; a pipeline reactor adopts a production-line process, and is small in device and large in yield.

Description

technical field [0001] The invention relates to a pharmaceutical chemical intermediate, in particular to a nitration device and a nitration process for preparing o-nitrobenzaldehyde. Background technique [0002] O-Nitrobenzaldehyde is a yellowish solid with a melting point of 41-43°C, insoluble in water, and easily soluble in organic solvents such as alcohols, ethers, aromatic hydrocarbons, halogenated hydrocarbons, and esters. The molecular formula of o-nitrobenzaldehyde is C7H5NO3, and the relative molecular mass is 151.1. The chemical structural formula of o-nitrobenzaldehyde is: [0003] [0004] O-nitrobenzaldehyde is a class of important pharmaceutical intermediate organic functional materials, mainly used for the preparation of nifedipine and other drugs for the prevention and treatment of hypertension and cardiovascular diseases, as well as for the preparation of expectorant and anti-inflammatory drugs such as ambroxine. O-nitrobenzaldehyde is also an important...

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Problems solved by technology

[0006] The technical problem to be solved by the present invention is that in the nitration process of o-nitrobenzaldehyde prepared by the traditional process, the nitration reaction is a dangerous process, and the nitration temperature and the nitration reaction speed should be strictly controlled in the nitration process. When elements such as water and reaction equipment stirring fail, when the heat energy generated by the reaction cannot be removed quickly, the temperature will rise sharply, resulting in the risk of explosion, and the current o-nitrobenzaldehyde production device is large in size, and there are safety hazards in the nitrification reaction process. The problem of uncontrollable risk

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