8 results about "O-nitrobenzaldehyde" patented technology

The invention discloses THK01 and derivatives thereof, a preparation method and application of THK01 and derivatives thereof in preparation of anti-inflammatory drugs, and the THK01 and derivatives thereof are prepared by performing a series of chemical reactions on o-nitrobenzaldehyde containing a specific substituent group, including Wittig reaction, Diels-Alder reaction, Cadolan reaction, Fischer indole synthesis reaction, demethylation reaction, reduction reaction, click chemical reaction and the like. The THK01 structure modified derivatives with different substituent groups are obtained. The THK01 structure modified derivative disclosed by the invention is diversified in synthetic route and high in reaction success rate; in-vitro and in-vivo experiments show that the compounds can significantly inhibit NO generation and inflammatory response at low concentration, and can effectively treat inflammatory bowel disease and acute pneumonia induced by H1N1 virus in an animal model. These findings provide valuable candidate compounds and new treatment strategies for developing novel, safe and efficient anti-inflammatory drugs.

The reaction system comprises a bromination reaction kettle, a hydrolysis reaction kettle, an oxidation reaction kettle and a refining reaction kettle, and is characterized in that a feeding hole and an upper circulating pipe are arranged at the top end of the refining reaction kettle, and a lower circulating pipe is arranged at the bottom end of the refining reaction kettle; a product discharge port is formed in the side surface of the refining reaction kettle; and a filter plate is arranged in the refining reaction kettle. Through the synergistic effect of the rotatable filter plate and the lifting blocking frame, the fan-shaped blocking plate is in a vertical state during suction filtration, so that full-effect filtration is realized; when blockage is detected, the lifting blocking frame moves upwards to enable the fan-shaped blocking plate to horizontally close most of the filters, only a single flushing opening is reserved for high-pressure backwashing, the filters can be subjected to backwashing one by one in cooperation with a rotating structure of the filter plate, the problems that a traditional fixed filter plate is prone to blockage and not thorough in cleaning are effectively solved, and the filtering efficiency is improved.

The present application relates to the technical field of nitrofurans metabolite content determination, and particularly relates to a method for determining the residual amount of nitrofurans metabolite in propolis. The method is that the pretreated propolis sample is detected by liquid chromatography-tandem mass spectrometry after gradient elution of the mobile phase; the pretreatment is that the propolis sample is sequentially hydrolyzed by hydrochloric acid, purified by HLB solid phase extraction column, derivatized by o-nitrobenzaldehyde, and purified by ethyl acetate treatment. The present application purifies the propolis sample after hydrochloric acid hydrolysis before o-nitrobenzaldehyde derivatization, so that o-nitrobenzaldehyde fully reacts with the nitrofurans metabolite in propolis, and the residual amount of nitrofurans metabolite in propolis is accurately detected by combining the selection and gradient elution of the mobile phase.

The application discloses a spinel structure Cu 0.5 Co 0.5 Al2O4 catalyst and a method for catalytically preparing o-nitrobenzaldehyde, and belongs to the field of chemical synthesis. The method uses o-nitrobenzyl alcohol as a raw material, dissolves the raw material in an organic solvent, uses spinel structure Cu 0.5 Co 0.5 Al2O4 as a reaction system catalyst, adds TEMPO as a cocatalyst, and reacts in a fixed bed under the condition of oxygen being introduced. After the reaction is completed, the reaction system is cooled to normal temperature, is dissolved, and then a crude product is obtained. The conversion rate of the reaction is 100%, and the selectivity is 98.9%. The crude product is purified through recrystallization of n-hexane, and then o-nitrobenzaldehyde is obtained. The product has a gas phase purity of 99.95%. The spinel structure Cu 0.5 Co 0.5 Al2O4 spinel catalyst has high catalytic activity and high catalytic stability, and has recycling usability, and therefore provides an efficient, economical and green and environment-friendly synthesis method for o-nitrobenzaldehyde.

The invention provides a synthesis method of an indazolo [2, 3-a] quinoline compound, which is characterized in that o-nitrobenzaldehyde and aniline are taken as starting raw materials, and the indazolo [2, 3-a] quinoline compound with various substituent groups is successfully synthesized through three-step reaction of synthesis of 2-aryl indazole, synthesis of 3-bromo-2-aryl indazole and synthesis of the indazolo [2, 3-a] quinoline compound. And by introducing the halogenated 2-phenyl indazole intermediate, the yield is remarkably improved. The synthesis method provided by the invention has the advantages of cheap and easily available raw materials, mild reaction conditions and good industrialization prospects.

The present invention discloses a method for generating 2-quinolinecarboxylic acid by using a chemo-enzymatic cascade reaction in a microfluidic field, which comprises the following steps: S1: Catalyze the aldol condensation reaction of o-nitrobenzaldehyde and sodium pyruvate by using pyruvate-dependent aldolase (NahE) to obtain 4-(2-nitrophenyl)-2-oxobut-3-enoic acid; S2: Reduce the nitro group of the 4-(2-nitrophenyl)-2-oxobut-3-enoic acid intermediate to an amino group by using iron powder, and then spontaneously generate 2-quinolinecarboxylic acid. The present invention uses a microfluidic field to combine chemical and enzymatic catalysis to obtain a quinoline ring drug intermediate from o-nitrobenzaldehyde, and has the advantages of mild reaction conditions, system compatibility, strong sustainability, high product yield, etc.

The application discloses o-nitrobenzaldehyde and a synthesis method thereof, and belongs to the technical field of medical intermediates. The synthesis method comprises the following steps: dissolving o-nitrotoluene, dibromohydantoin and azobisisobutyronitrile in mixed organic solvents to perform a bromination reaction, then performing filtration, impurity removal, extraction and organic phase drying in sequence, and separating o-nitrodibromobenzene; adding the o-nitrodibromobenzene into a DMSO solution, adding calcium carbonate to perform an oxidation reaction, then performing filtration, extraction, organic phase drying and purification and decoloration in sequence, and obtaining o-nitrobenzaldehyde. The o-nitrobenzaldehyde is obtained through a bromination oxidation two-step reaction, the synthesis method has the advantages of simple process, low cost, small pollution and high product yield.

This invention discloses a method for preparing 3,5-dibromo-o-aminobenzaldehyde, belonging to the field of pharmaceutical intermediate synthesis technology. The method includes a reduction step, a bromination step, and a purification step. In the reduction step, o-nitrobenzaldehyde is used as raw material, and is obtained by iron powder reduction, toluene extraction, and dilute sulfuric acid back-extraction to obtain an aqueous solution of o-aminobenzaldehyde sulfate. In the bromination step, a hydrogen peroxide and hydrobromic acid system is used for the bromination reaction to obtain a crude product and a centrifuged acid mother liquor. The centrifuged acid mother liquor is decolorized, concentrated, and the dilute sulfuric acid is recovered and reused in the reduction step. In the purification step, the crude product is dissolved in acetone, crystallized, and dried to obtain a refined product. The acetone mother liquor is decolorized and subjected to multi-stage distillation to recover acetone for recycling. This invention achieves the recycling of dilute sulfuric acid and acetone, significantly reducing waste emissions, lowering production costs, and improving product yield and purity. It has the advantages of being green, environmentally friendly, economical, and efficient, and is suitable for industrial production.