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Extraction process of isofebrifugine

A technology of abnormal mountain alkali and extraction process, which is applied in the direction of organic chemistry, can solve the problems of high cost and insufficient extraction, and achieve the effect of improving extraction rate and simple process

Inactive Publication Date: 2018-12-14
湖州展舒生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, when extracting abnormal mountain alkali from Changshan, the extraction is not thorough enough, the cost is high, and it cannot meet the needs of the market

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] The present invention will be described in further detail below through specific examples.

[0014] An extraction process of abnormal mountain alkali, comprising the following steps:

[0015] 1), Changshan is sent to the pulverizer for crushing, and the crushed Changshan is obtained;

[0016] 2) Carry out two ethanol reflux extractions on the pulverized Changshan, so as to obtain the extract, the concentration of ethanol is 60-85%;

[0017] 3), the extract is concentrated, and then 5% aqueous hydrochloric acid solution is added for extraction;

[0018] 4), then add concentrated ammonia water to neutralize, filter and use 40% dilute ethanol to coarsely crystallize, then dissolve the crystals in dilute hydrochloric acid, concentrate and recrystallize with acetone to obtain anomaline.

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Abstract

The invention discloses an extraction process of isofebrifugine. The extraction process comprises the following steps: 1) feeding radix dichroae into a crusher for crushing to obtain crushed radix dichroae; 2) performing ethanol reflux extraction on the crushed radix dichroae twice to obtain an extracting solution; 3) concentrating the extracting solution and then adding 5% aqueous solution of hydrochloric acid for extraction; 4) then adding concentrated ammonia solution for neutralization, filtering and then coarsely crystallizing with 40% diluted ethanol, dissolving crystals in diluted hydrochloric acid, concentrating, and recrystallzing with acetone to obtain the isofebrifugine. The extraction process provided by the invention coarsely crystallizes with the diluted ethanol and then recrystallizes with the acetone to greatly increase an extraction rate of isofebrifugine; the extraction process is simple.

Description

technical field [0001] The invention relates to a process for extracting abnormal mountain alkali. Background technique [0002] The molecular formula of abnormal mountain alkali is C 16 h 19 N 3 o 3 , the molecular weight is 301.34, it is off-white crystal at normal temperature and pressure, mainly from Changshan, insoluble in water and ethanol, easily soluble in chloroform, stable at room temperature, and needs to be stored in a cool place away from light. [0003] At present, when extracting abnormal mountain alkaloids from Changshan, the extraction is not thorough enough, the cost is high, and it cannot meet the needs of the market. Contents of the invention [0004] In view of the above problems, the present invention provides an extraction process of anomalus, which is simple, thorough, and low in cost. [0005] The technical scheme adopted in the present invention is: [0006] An extraction process of abnormal mountain alkali, comprising the following steps: ...

Claims

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Application Information

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IPC IPC(8): C07D491/048
CPCC07D491/048
Inventor 吴建华
Owner 湖州展舒生物科技有限公司