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Application of molecular marker combination to risk assessment of pneumonia patients

A technology of molecular markers and risk assessment, applied in the application field of risk assessment, can solve the problems of specificity, low sensitivity, delay of disease development, late report of results, etc., and achieve the effect of preventing antibiotic abuse and benefiting disease treatment

Inactive Publication Date: 2018-12-14
FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the specificity and sensitivity of the above methods are relatively low, and the results are reported relatively late, making timely and effective clinical diagnosis impossible, and may even delay the development of the disease

Method used

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  • Application of molecular marker combination to risk assessment of pneumonia patients
  • Application of molecular marker combination to risk assessment of pneumonia patients
  • Application of molecular marker combination to risk assessment of pneumonia patients

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Embodiment 1

[0021] Application of Molecular Marker Combination in Risk Assessment of Patients with Pneumonia

[0022] 1. Test objects and groups

[0023] From January 2015 to December 2017, 400 cases of 65-year-old elderly patients with pneumonia admitted to the Department of Respiratory Medicine of the First Affiliated Hospital of Kunming Medical University were collected and analyzed retrospectively. The collected test subjects were divided into three groups, and the grouping and grouping criteria were as follows:

[0024] Group A: (1) elevated blood cells, more than 80% of neutrophils, and left-shifted nuclei; (2) lower respiratory tract tissue culture, Gram staining and capsular staining microscopic examination, if found typical Gram Positive staining, encapsulated diplococci or streptococci are initially regarded as etiological diagnosis. At the same time, samples are required to be submitted for examination in time, collected after gargling before the application of antibiotics, a...

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Abstract

The invention relates to the field of immunodiagnosis, in particular to an application of a molecular marker combination to the risk assessment of pneumonia patients. The molecular marker combinationcomprises PCT and CRP; the PCT and CRP content in the elderly infectious pneumonia patients at different disease course stages has difference; and the AUC value of the PCT is 0.868, and the AUC valueof the CRP is 0.790. According to the application, the molecular marker combination content in the serum of the pneumonia patients of different disease courses has significant difference; and the detection of the molecular marker combination is beneficial to auxiliary diagnosis, disease staging, antibiotic treatment guidance, curative effect detection and prognosis evaluation.

Description

technical field [0001] The invention relates to the field of immunodiagnosis, in particular to the application of a combination of molecular markers in the risk assessment of pneumonia patients. Background technique [0002] Biomarkers refer to biochemical indicators that can mark changes or possible changes in system, organ, tissue, cell and subcellular structure or function, and have a very wide range of uses. Biomarkers can be used for disease diagnosis, judgment of disease stage, or to evaluate the safety and effectiveness of new drugs or new treatments in the target population. [0003] Serum procalcitonin (PCT) is a biomarker developed in recent years that can accurately reflect the infection of respiratory patients. Under normal metabolism, thyroid C cells and endocrine cells of the lungs can produce PCT. and activate it into calcitonin. Normal adults have serum PCT levels < 0.05 μg / L, while the elderly and patients with chronic diseases have serum PCT levels >...

Claims

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Application Information

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IPC IPC(8): G01N33/574
CPCG01N33/57484
Inventor 段勇赵滢宋贵波马晓波张娟
Owner FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIV