A kind of plant source small molecule oral cleaning agent and preparation method thereof
A plant-derived, small-molecule technology, applied in oral care, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as abnormal fermentation of the intestinal tract, intestinal health imbalance, oral odor, etc., to reduce oral and The effect of excrement odor, solving oral problems, and strengthening immunity
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Embodiment 1
[0045] 1. Preparation of sea buckthorn fruit liquid
[0046] (1), select 100g of plant fruit without insects and moths, remove impurities, and dry after cleaning for subsequent use; drying adopts a constant temperature drying oven at 40°C;
[0047] (2), pulverize the dried plant fruit with a pulverizer, pass through a 40-mesh sieve to obtain plant fruit powder, and place it in a dry environment for subsequent use;
[0048] (3), the plant fruit powder is added in the methanol solution according to the weight volume ratio of 1g: 3ml, microwave extraction, the volume concentration of the methanol solution is 60%; before the microwave extraction step, the plant fruit powder is soaked in the methanol solution for 0.5 h; during the microwave extraction step, the plant fruit powder is added to the methanol solution, the temperature of the microwave extraction is 20°C, the microwave frequency is 915MHz, and the extraction time is 6h; a yellow-brown semi-solid solution is obtained;
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Embodiment 2
[0065] 1. Preparation of sea buckthorn fruit liquid
[0066] (1), select 100g of plant fruit without insects and moths, remove impurities, dry after cleaning and set aside; drying adopts a constant temperature drying oven at 50°C;
[0067] (2), pulverize the dried plant fruit with a pulverizer, and pass through an 80-mesh sieve to obtain plant fruit powder, which is placed in a dry environment for subsequent use;
[0068] (3), plant fruit powder is added in the methanol solution according to the weight volume ratio of 1g: 5ml, microwave extraction, the volume concentration of methanol solution is 95%; h; during the microwave extraction step, the plant fruit powder is added to the methanol solution, the temperature of the microwave extraction is 40°C, the microwave frequency is 1500MHz, and the extraction time is 3h; a yellow-brown semi-solid solution is obtained;
[0069] (4), centrifuging the tan semisolid solution to remove insoluble impurities to obtain a dark tan liquid; ...
Embodiment 3
[0087] Randomly select 30 pet dogs suffering from bad breath as experimental subjects, use the plant-derived small-molecule oral cleanser prepared in the above-mentioned embodiment 1-2 as experimental group 1-2, and use commercially available common pet oral cleanser as experimental group 1-2. In the control group, 30 pet dogs were randomly divided into 3 groups, 10 in each group, and the oral cleaning agents of the experimental group 1-2 and the control group were administered respectively, once in the morning and evening, and the improvement of the bad breath of the pet dogs was observed every day. 30 days, record the time (mean value) of the elimination of bad breath, even still keep observing after the bad breath is eliminated, record the quantity that recurrence occurs in every group, result is as follows table 1:
[0088] Experimental group 1 Experimental group 2 control group Time to eliminate bad breath (days) 3.8 4.2 8.9 Number of recurrence...
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