Heparin biological detection chip
A biological detection and chip technology, applied in the direction of measuring devices, material analysis through electromagnetic means, instruments, etc., can solve the problems of platelet test results, etc., and achieve the effect of reducing interference and measuring quickly and accurately
Inactive Publication Date: 2018-12-18
安徽健朗医疗器械有限公司
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Problems solved by technology
Based on the function of heparin, at present, the analysis methods for heparin detection mainly include the whole blood activated coagulation time method. However, the whole blood activated coagulation time method needs to be measured with whole blood, and the existence of platelets will affect the experimental results. Therefore, now Technical heparin testing needs improvement
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[0019] The specific implementation manner of the present invention will be described in further detail below by describing the best embodiment with reference to the accompanying drawings.
[0020] This example: using the specific binding of protamine in the polymer sensitive membrane phase adhered by the ion-selective electrode to heparin in the water phase, the potential change after adding different concentrations of heparin was measured by a potentiometer, and according to the resulting potential change rate Determination of the concentration of heparin in the sample to be tested;
[0021] The polymer sensitive membrane attached to the ion-selective electrode head is composed of polymer matrix material, plasticizer, ion carrier and lipophilic inert salt, and the ratio of parts by weight is 20-40:40-80:0.1-10: 0.1-10 mixed, blended into excess tetrahydrofuran solution, stirred to make it into a uniform solution, and then placed at room temperature for 12-24h to obtain an ela...
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The invention discloses a heparin detection chip comprising an ion selective electrode and a reference electrode. The ion selective electrode and the reference electrode are inserted into a measuringpool containing a to-be-detected sample and are connected with a potential measuring instrument, wherein a polymer sensitive film is adhered to the end of the ion selective electrode. The potential measuring instrument is connected with a data processing chip through a communication isolation chip. The data processing chip is connected with a database. The database pre-stores a corresponding relationship curve between the change rate of the calibrated potential and the concentration of heparin, through the pre-stored corresponding curve between the change rate of the potential and the concentration of heparin and the detected potential change rate, the data processing chip obtains the heparin concentration of the to-be-detected sample. The data processing chip is connected with a communication interface to connect with an external server. This chip has the advantages of fast and accurate measurement and lower possibility of interference and with the communication interface, can send the measured data to the cloud for monitoring directly.
Description
technical field [0001] The invention relates to the field of biological parameter measurement, in particular to a heparin detection chip. Background technique [0002] Heparin is an anticoagulant, which is a polymer composed of two polysaccharides connected alternately, and has anticoagulant effects both in vivo and in vitro. Clinically, it is mainly used for thromboembolic diseases, myocardial infarction, cardiovascular surgery, cardiac catheterization, extracorporeal circulation, hemodialysis, etc. With the progress of pharmacology and clinical medicine, the application of heparin has been expanding. Based on the function of heparin, at present, the analysis methods for heparin detection mainly include the whole blood activated coagulation time method. However, the whole blood activated coagulation time method needs to be measured with whole blood, and the existence of platelets will affect the experimental results. Therefore, now Technical heparin testing needs to be im...
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IPC IPC(8): G01N27/416
CPCG01N27/416
Inventor 张士伟凌中鑫
Owner 安徽健朗医疗器械有限公司