Application of TRERNA1 gene to prediction and improvement of sensitivity of liver cancer drug sorafenib

Abstract

The invention belongs to the technical field of biology, particularly relates to the field of medical diagnosis, in particular to application of TRERNA1 gene to prediction and improvement of sensitivity of liver cancer drug sorafenib. The prognosis of hepatocellular carcinoma and the evaluation of chemotherapy resistance of liver cancer are marked, and the expression level of TRERNA1 genes is detected by utilizing an RNA in-situ hybridization technology or qPCR, so that the prognosis and chemotherapy resistance of the hepatocellular carcinoma can be obtained, the introduction way of the TRERNA1 is simple, the whole prediction and evaluation process is simple and easy, and the feasibility is high.

Description

technical field [0001] The invention belongs to the field of biotechnology, in particular to the field of medical diagnosis, and more specifically relates to the application of TRERNA1 gene in predicting and improving the chemotherapy sensitivity of hepatocellular carcinoma drug Sorafenib. Background technique [0002] Liver cancer is a malignant tumor of the liver, which can be divided into two categories: primary and secondary. Primary malignant tumors of the liver originate from the epithelial or mesenchymal tissues of the liver. The former is called primary liver cancer, which is a malignant tumor with a high incidence in my country and is extremely harmful; rare. [0003] The etiology and exact molecular mechanism of primary liver cancer are not yet fully understood. At present, it is believed that its pathogenesis is a multi-factor and multi-step complex process, which is affected by environmental and therefore dual factors. Epidemiological and experimental research d...

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Problems solved by technology

[0005] However, at present, there is no such curative effect prediction means and methods at home and abroad, which greatly reduces the accuracy and effectiveness of clinical postoperative treatment plans, especially chemotherapy treatment plans.

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