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Inhalation preparation of isoglycyrrhizic acid or its salt and its application

An inhalation preparation, the technology of magnesium isoglycyrrhizinate, applied in the preparation of medicines for treating respiratory diseases, the field of inhalation preparations of magnesium isoglycyrrhizinate, can solve problems such as applications that have not yet been reported

Active Publication Date: 2020-09-04
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the application of glycyrrhizic acid inhalation preparations in the preparation of expectorant drugs and drugs for the treatment of chronic obstructive pulmonary disease

Method used

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  • Inhalation preparation of isoglycyrrhizic acid or its salt and its application
  • Inhalation preparation of isoglycyrrhizic acid or its salt and its application
  • Inhalation preparation of isoglycyrrhizic acid or its salt and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Example 1: Magnesium Isoglycyrrhizinate Inhalation Powder

[0077] Magnesium isoglycyrrhizinate was treated by micronization to obtain the following samples with different particle size ranges.

[0078] Active ingredient particle size x 10 / μm

Embodiment 1a

[0080] prescription:

[0081]

[0082] Preparation Process:

[0083] 1), take prescription quantity magnesium isoglycyrrhizinate and prescription quantity lactose;

[0084] 2), sieving and mixing;

[0085] 3), filling capsules according to 30mg / capsule, so that each capsule contains 10mg of magnesium isoglycyrrhizinate;

[0086] 4) According to the requirements of "Chinese Pharmacopoeia" Four General Rules 0111, the key quality indicators of the inhalation powder and aerosol are tested.

Embodiment 1b

[0088] prescription:

[0089]

[0090] Preparation Process:

[0091] 1), take prescription quantity magnesium isoglycyrrhizinate and prescription quantity lactose;

[0092] 2), sieving and mixing;

[0093] 3), filling capsules according to 30mg / capsule, so that each capsule contains 10mg of magnesium isoglycyrrhizinate;

[0094] 4) According to the requirements of "Chinese Pharmacopoeia" Four General Rules 0111, the key quality indicators of the inhalation powder and aerosol are tested.

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PUM

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Abstract

The invention belongs to the field of medicine, and relates to an inhalation preparation of isoglycyrrhizinate or a salt thereof, in particular to an inhalation preparation of magnesium isoglycyrrhizinate and its application in the preparation of medicines for treating respiratory diseases.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to Chinese Application No. 201610237175.3 filed on April 15, 2016, which is hereby incorporated by reference in its entirety. technical field [0003] The application belongs to the field of medicine, and relates to an inhalation preparation of isoglycyrrhizinate or a salt thereof, in particular to an inhalation preparation of magnesium isoglycyrrhizinate and its application in the preparation of medicines for treating respiratory diseases. Background technique [0004] Glycyrrhizae (Glycyrrhiza) is a commonly used medicinal plant, and its main active ingredients are glycyrrhizic acid substances, namely glycyrrhizic acid in 18-β configuration and glycyrrhizic acid in 18-α configuration (also known as isoglycyrrhizic acid). Chinese patent ZL02111693.8 discloses a new compound magnesium isoglycyrrhizinate (structure as shown in formula I, molecular weight 845), through a large number of p...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/72A61K9/12A61K31/704A61P1/16A61P31/12
CPCA61K9/0073A61K9/0078A61K9/12A61K31/704B82Y5/00A61P1/16A61P11/10A61P31/12A61K47/02A61K47/12A61K47/24A61K9/0075A61P11/00A61K47/26A61K9/08A61K9/0019
Inventor 顾红梅王善春张喜全黄磊徐宏江宋伟董平孙中英张颖陈德洋
Owner CHIA TAI TIANQING PHARMA GRP CO LTD