Computer-implemented evaluaton of drug safety for a population

A security, computer technology, applied in the field of drug safety assessment, can solve the problem of not providing useful and reliable drug information
CN109074428AInactive Publication Date: 2018-12-21CIPHEROME INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CIPHEROME INC
Publication Date
2018-12-21
Estimated Expiration
Not applicable · inactive patent

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Abstract

A computer-implemented drug evaluation method and system provides for evaluating safety of a drug or a drug group by performing certain computations associated with gene sequence variation informationof individuals within a population. The system calculates various scores for individual within a population and ultimately combines the scores in determining safety of the drug across the population.The drug evaluation method and a system can further be configured for identifying individuals having a high-risk of side effects to a drug or a drug group. The drug evaluation provides universal drugsafety information based on gene sequence variation information without the need to identify specific genetic markers for each drug.
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Description

[0001] Cross References to Related Applications

[0002] This application claims the benefit of US Provisional Application No. 62 / 266,578, filed December 12, 2015, which is incorporated herein by reference in its entirety. technical field

[0003] The present invention relates generally to computer-implemented assessment of drug safety, and more particularly to computer-implemented assessment of drug safety for an entire population of individuals. Background technique

[0004] Clinical studies are usually conducted under the assumption that there are no significant changes in the population in genes associated with the absorption, metabolism, action and excretion of the drug. As a result, subgroups at high pharmacogenetic risk may be underrepresented in small clinical studies involving 2,000 to 3,000 subjects, and not all side effects of drugs are discovered through clinical studies. In fact, there are many drugs that were once released on the market but were later withdraw...

Claims

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