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Computer-implemented evaluaton of drug safety for a population

A security, computer technology, applied in the field of drug safety assessment, can solve the problem of not providing useful and reliable drug information

Inactive Publication Date: 2018-12-21
CIPHEROME INC
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Apart from methods based on observational studies of populations using markers such as single nucleotide polymorphisms, previous work does not provide useful and reliable drug information for various subpopulations

Method used

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  • Computer-implemented evaluaton of drug safety for a population
  • Computer-implemented evaluaton of drug safety for a population
  • Computer-implemented evaluaton of drug safety for a population

Examples

Experimental program
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Effect test

example 2

[0194] Individual drug safety scores showed a broad distribution from the lowest score of 0 to the highest score of 1, according to the diversity of individual genetic variants found in drug-associated genes. All drug safety scores will be 1 if there are no functional variants in genes related to the pharmacodynamics or pharmacokinetics of a drug in a particular population group. Therefore, the area under the individual drug safety score distribution curve will be 1, and the effect of the drug will be achieved as expected.

[0195] Figure 4A to Figure 4C Presented are graphs showing methods for assessing drug safety using individual drug safety scores calculated as described above. Figure 4A Three distribution curves are shown representing individual drug safety scores from 2504 individuals (provided by Phase III of the 1000 Genomes Project), each with three drugs belonging to C01BA antiarrhythmic drugs according to the ATC classification system - Corresponding to one of d...

example 5

[0204] Individuals can respond differently to different drugs within the same drug group. For example, if Figure 7A to Figure 7F As shown, N05BA drugs (benzodiazepine derivatives) classified as antipsychotics by the anatomical therapeutic chemistry (ACT) classification show different distribution patterns of individual drug safety scores. like Figure 8A to Figure 8F As shown, C10AA drugs (HMG CoA reductase inhibitors) classified as lipid modifiers by the Anatomical Therapeutic Chemistry (ACT) classification system provided by WHO also showed different individual drug safety score distribution patterns.

[0205] These individual drug safety score distribution curves can be used to select the safest drug for a subject by identifying the subject's rank within the individual drug safety score distribution curve for each drug. For example, a subject may be in a high-risk subgroup for a first drug, but not in a high-risk subgroup for a second drug. In this case, the subject may...

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Abstract

A computer-implemented drug evaluation method and system provides for evaluating safety of a drug or a drug group by performing certain computations associated with gene sequence variation informationof individuals within a population. The system calculates various scores for individual within a population and ultimately combines the scores in determining safety of the drug across the population.The drug evaluation method and a system can further be configured for identifying individuals having a high-risk of side effects to a drug or a drug group. The drug evaluation provides universal drugsafety information based on gene sequence variation information without the need to identify specific genetic markers for each drug.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application No. 62 / 266,578, filed December 12, 2015, which is incorporated herein by reference in its entirety. technical field [0003] The present invention relates generally to computer-implemented assessment of drug safety, and more particularly to computer-implemented assessment of drug safety for an entire population of individuals. Background technique [0004] Clinical studies are usually conducted under the assumption that there are no significant changes in the population in genes associated with the absorption, metabolism, action and excretion of the drug. As a result, subgroups at high pharmacogenetic risk may be underrepresented in small clinical studies involving 2,000 to 3,000 subjects, and not all side effects of drugs are discovered through clinical studies. In fact, there are many drugs that were once released on the market but were later withdraw...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F19/18G06F19/24C12Q1/68G16B20/20G16B20/40G16B40/00
CPCC12Q1/6883C12Q2600/106C12Q2600/156G16B20/00G16B40/00G16H10/20G16B20/40G16B20/20C12Q1/68
Inventor 李桂花保罗·J·帕克
Owner CIPHEROME INC
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