Preparation method and application of multilayer functional scaffold with controllable three-dimensional structure

A three-dimensional structural and functional technology, applied in the field of medical materials, can solve problems such as narrowing the application scope of multi-layer stents, and achieve the effect of strong capillary force, high production efficiency, and helpful adsorption

Active Publication Date: 2021-04-13
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

On the other hand, it is hampered by the difficulty in converting the prepared preformed material into new scaffolds with different structures, and greatly reduces the application range of multilayer scaffolds.

Method used

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  • Preparation method and application of multilayer functional scaffold with controllable three-dimensional structure
  • Preparation method and application of multilayer functional scaffold with controllable three-dimensional structure
  • Preparation method and application of multilayer functional scaffold with controllable three-dimensional structure

Examples

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Effect test

Embodiment 1

[0038] A method for preparing a multilayer functional scaffold with a controllable three-dimensional structure, comprising the following steps:

[0039] Step 1: Put 800g PLLA pellets and 1200g PEO pellets in an oven at 40°C, dry for 12 hours, dry the water, put them in a super large ziplock bag and mix them evenly, then put them in a single-screw extruder for melting Blend and extrude strands at an extrusion temperature of 170° C. and a screw speed of 20 rpm / min.

[0040] Step 2: Use a three-roller calender to cool the strip obtained in step 1 without stretching, and then cut it into a strip with a length of 40 cm to obtain a polylactic acid / polyethylene oxide with an alternating multi-layer concentric cylindrical structure. alkanes extrudates.

[0041] Step 3: Cut the polylactic acid / polyethylene oxide extrudate obtained in step 2 into strips with a length of 10 mm, and then fix them in custom-made triangular, rectangular and oval molds, and vacuum film laminator The temper...

Embodiment 2

[0049] A method for preparing a multilayer functional scaffold with a controllable three-dimensional structure, comprising the following steps:

[0050] Step 1: Put 800g PLLA pellets and 1200g PEO pellets in an oven at 30°C, dry for 24 hours, dry the water, put them in a super large ziplock bag and mix them evenly, then put them in a single-screw extruder for melting Blend and extrude strands at an extrusion temperature of 170° C. and a screw speed of 40 rpm / min.

[0051] Step 2: Use a three-roll calender to cool the strip obtained in step 1 without stretching, and then cut it into a strip with a length of 60 cm to obtain a polylactic acid / polyethylene oxide with an alternating multi-layer concentric cylindrical structure. alkanes extrudates.

[0052] Step 3: Cut the polylactic acid / polyethylene oxide extrudate obtained in step 2 into strips with a length of 10 mm, and then fix them on a three-jaw chuck and place them under a micro electric drill. The drill bits of 0.6mm and...

Embodiment 3

[0056] A method for preparing a multilayer functional scaffold with a controllable three-dimensional structure, comprising the following steps:

[0057] Step 1: Put 800g PLLA pellets and 1200g PEO pellets in an oven at 40°C, dry for 24 hours, dry the water, put them in a super large ziplock bag and mix them evenly, then put them in a single-screw extruder for melting Blend and extrude strands at an extrusion temperature of 170° C. and a screw speed of 30 rpm / min.

[0058] Step 2: Use a three-roller calender to cool the strip obtained in step 1 without stretching, and then cut it into a strip with a length of 40 cm to obtain a polylactic acid / polyethylene oxide with an alternating multi-layer concentric cylindrical structure. alkanes extrudates.

[0059] Step 3: Cut the polylactic acid / polyethylene oxide extrudate obtained in step 2 into a strip with a length of 20 mm, and wind an enameled wire with a diameter of 0.1 mm to the surface of the strip in a spiral manner. There is...

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Abstract

The invention belongs to the technical field of medical materials, and discloses a preparation method and application of a three-dimensional controllable structure multi-layer functional bracket. Put it in an oven to dry the water, then put it in a single-screw extruder for melt blending, and extrude the strip; use a three-roll calender for non-stretching cooling, and then cut it into a length of 40~ 60cm strips to obtain polylactic acid / polyethylene oxide extrudates with alternating multi-layer concentric cylindrical structure; the polylactic acid / polyethylene oxide extrudates are cut into strips with a length of 5~20mm , the stent preform is obtained through a hot pressing process, a drilling process or a winding process; the stent preform is placed in deionized water to remove the polyethylene oxide layer, and leached to obtain a multi-layer functional stent with a controllable three-dimensional structure. The method has the advantages of simple process, wide applicability, low cost, environmental friendliness, high production efficiency and wide application range of the bracket.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a preparation method and application of a three-dimensional controllable multilayer functional bracket. Background technique [0002] Organisms in nature have gradually evolved various exquisite structures that in many cases have extraordinary functions. As one of the most representative and fascinating examples, biological multilayer architectures exhibit various forms in living organisms (such as bones, blood vessels, and skin, etc.). Such a structure plays the role of supporting the organism, preventing bleeding and barrier. In general, biological multilayer architecture consists of two parts, the macroscopic assembly of microlayers and the individual microlayers at the microscale. On a macroscopic scale (from hundreds of micrometers to millimeters), scaffolds with three-dimensional structures can not only mimic natural tissue structures, but also allow...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/18A61L27/54A61L27/38A61L27/50A61L27/56
CPCA61L27/18A61L27/38A61L27/50A61L27/54A61L27/56A61L2300/602C08L67/04C08L71/02
Inventor 郑国强成肖鹏赵康李睢水史红辉代坤刘春太
Owner ZHENGZHOU UNIV
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