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Application of methyl brevifolincarboxylate in preparation of anti-influenza virus medicines

A technology of methyl hematoxylate and hematoxylate, which is applied in the field of application of methyl hematoxylate in the preparation of anti-influenza virus drugs, to achieve the effect of enhanced inhibitory effect

Active Publication Date: 2019-01-01
SOUTHERN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0014] Most of the above-mentioned drugs are chemically synthesized drugs, which have certain side effects, so it is of great significance to extract the active ingredients against influenza virus from natural substances

Method used

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  • Application of methyl brevifolincarboxylate in preparation of anti-influenza virus medicines
  • Application of methyl brevifolincarboxylate in preparation of anti-influenza virus medicines
  • Application of methyl brevifolincarboxylate in preparation of anti-influenza virus medicines

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Embodiment Construction

[0031] Application of brevifolia hematoxylate in the preparation of anti-influenza virus drugs.

[0032] As a further improvement of the above application, the brevifolia hematoxylin acid ester is a pharmaceutically acceptable ester of brevifolia hematoxylin acid.

[0033] As a further improvement of the above application, the pharmaceutically acceptable ester of brevifolia hematoxylin is its C1-C4 ester.

[0034] As a further improvement of the above application, the brevifolia hematoxylate is methyl brevifolia hematoxylate.

[0035] A composition for treating influenza, whose active ingredients include brevifolia hematoxylin ester, and at least one active ingredient for anti-influenza virus, or an active ingredient for improving flu symptoms.

[0036] As a further improvement of the above composition, the pharmaceutically acceptable ester of brevifolia hematoxylin is its C1-C4 ester. Further, the brevifolia hematoxylate is methyl brevifolia hematoxylate.

[0037] The tech...

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Abstract

Application of methyl brevifolincarboxylate in preparation of anti-influenza virus medicines is disclosed. Through experiments, the inventors found that the methyl brevifolincarboxylate shows high resisting function against influenza A virus H1N1 subtype in a range of 0.78-100 [mu]g / mL and has an IC<50> value of 18.90 + / - 5.65 [mu]mol / L that is relatively lower than the IC<50> value ( 0.56 + / - 1.10 [mu]mol / L) of a contrast medicine that is ribavirin. Plaque experiment results show that the methyl brevifolincarboxylate can suppress, in a concentration-dependant manner, MDCK cell (Madin-Darby canine kidney cell) plaques caused by H1N1 viruses. The methyl brevifolincarboxylate can suppress expression of virus NP protein and PB2 polymerase in MDCK cells, and the suppressing function increasesalong with increase of the concentration. The methyl brevifolincarboxylate can suppress H3N2, with the IC<50> value being 71.74 + / - 1.48 [mu]g / mL.

Description

technical field [0001] The invention relates to a new application of the compound, in particular to the application of brevifolia hematoxylic acid methyl ester in the preparation of anti-influenza virus drugs. Background technique [0002] The molecular formula of methyl brevifolincarboxylate is C 14 h 10 o 8 . The CAS number is: 154702-76-8. The system is named methyl7,8,9-trihydroxy-3,5-dioxo-1,2,3,5-tetrahydrocyclopenta[c]isochromene-1-carboxylate. The structural formula is: [0003] [0004] Methyl brevifolia hematoxylate is extracted from green fruit. Green fruit is the fruit of olive [Canarium album (Lour.) Raeusch], which is a plant of the olive family Olivaceae. Green fruit is included in the 2015 edition of "Chinese Pharmacopoeia". It is often used to treat sore throat, cough, polydipsia, and fish and crab poisoning. [0005] Existing literature has shown that methyl brevifolia hematoxylate has the activity of inhibiting human herpes simplex virus HSV-1STA...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61P31/16
CPCA61K31/366A61P31/16
Inventor 段文军杨洁陈芳昭杨洛萍翟玲燕陈云陈金香谢宝平孙斌谢扬
Owner SOUTHERN MEDICAL UNIVERSITY
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