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Lung cancer marker anti-ACTR3 autoantibody and applications thereof

A technology of autoantibodies and markers, applied in the field of biomedical detection, can solve the problems of unsatisfactory tumor markers, and achieve the effect of low cost, high accuracy and simple operation

Active Publication Date: 2019-01-01
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to overcome the problem of unsatisfactory existing tumor markers of lung cancer, to provide a new application of anti-ACTR3 autoantibody, and to improve the sensitivity, specificity and accuracy of early diagnosis of lung cancer

Method used

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  • Lung cancer marker anti-ACTR3 autoantibody and applications thereof
  • Lung cancer marker anti-ACTR3 autoantibody and applications thereof
  • Lung cancer marker anti-ACTR3 autoantibody and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Collection of serum samples

[0030] A total of 1379 subjects were included in this study, which were divided into test group and verification group. The serum of 184 lung cancer patients included in the test group came from lung cancer patients in the First Affiliated Hospital of Zhengzhou University from 2016 to 2017. The sera of 446 lung cancer patients included in the verification group were from lung cancer patients who were treated in the First Affiliated Hospital of Zhengzhou University from 2013 to 2014. All cases were confirmed by histopathology without any operation, radiotherapy and chemotherapy. The 184 normal controls in the test group and the 446 normal controls in the verification group were all from healthy persons who underwent physical examination in the First Affiliated Hospital of Zhengzhou University. They were matched with cases according to age and sex, and they were free from tumor-related diseases and respiratory diseases. Sera from 119 cas...

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Abstract

The invention belongs to the technical field of biomedical detection, particularly relates to a lung cancer marker anti-ACTR3 autoantibody and applications thereof, and discloses a lung cancer marker,which is an anti-ACTR3 autoantibody. The invention further provides applications of the lung cancer marker in preparation of lung cancer detection kits. According to the present invention, the serumbiomarker with characteristics of simple operation, low cost, high accuracy and non-invasive application in clinic is provided; the research results show that the detection of the serum anti-ACTR3 autoantibody with the ELISA method can accurately distinguish lung cancer patients from normal people and patients with benign lung diseases, and can be used for early detection of lung cancer; and in the context, the marker for conveniently, rapidly and effectively detecting lung cancer patients and the lung cancer detection kit prepared by using the marker can be used for clinical early diagnosis of lung cancer.

Description

technical field [0001] The invention belongs to the technical field of biomedical detection, and in particular relates to a lung cancer marker anti-ACTR3 autoantibody and application thereof. Background technique [0002] Lung cancer is a malignant tumor with the highest morbidity and mortality in China and the world. The clinical manifestations of lung cancer are complex and diverse. The manifestations of early lung cancer are hidden and diverse, and the clinical features and signs are not obvious. They only manifest as non-specific symptoms such as cough, expectoration, chest pain, fever, and physical decline. late. According to clinical data, nearly 60% of patients are already in the advanced stage of lung cancer when they see a doctor. The 5-year survival rate of advanced lung cancer is only about 16%, while the 5-year survival rate of early stage lung cancer (stage I) can be as high as 70%. It can be seen that early detection and early diagnosis of lung cancer are th...

Claims

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Application Information

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IPC IPC(8): G01N33/574
CPCG01N33/57484
Inventor 代丽萍周志刚王猛齐宇欧阳松云裴露王婷婷谢伟
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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