Tumor-targeting nanoparticles, preparation method and application thereof

Abstract

The invention relates to the technical field of photothermal nanomaterials, particularly tumor-targeting nanoparticles, a preparation method and application thereof, the tumor targeting nanoparticleshave a spherical shell-core structure, comprises a PFOB core and an IR780 core liposome membrane surrounding the PFOB core, wherein the IR780 core liposome membrane comprises a liposome layer and IR780 iodide particles, and the tumor-targeting nanoparticles have a particle size range of 220 to 320 nm. The potential of the tumor targeting nanoparticles is-28.32- -19.48 mV, drug loading 3.87%-4.87%and encapsulation efficiency 85.7%-87.9%. The invention provides a tumor-targeting nanoparticle, preparation method and application thereof, which can evaluate tumor by preoperative photoacoustic imaging, CT imaging and near-infrared fluorescence imaging, optimize tumor resection under the guidance of intraoperative near-infrared fluorescence, and kill residual focus by auxiliary photothermal treatment during operation.

Description

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AI Technical Summary

Benefits of technology

The technology described in this patented innovator describes how certain types of particles called pFBO (Peroxis Biolobactor) could help make cancer cells easier to detect when they were alive or dead without harmful substances like chemotherapeusis agents that may also kill them themselves. These particles had been found effective at killing some forms of brain nerve disease while others did not show any significant difference from these treatments.

Problems solved by technology

This patents discusses different ways how it may be possible to develop an improved method called photothermal therapy for treatments involving solid tumours like lung cancer. These techniques involve converting infrared lights from sunlight onto specific molecules made of special chemical substances known as quantum dots. By doing this they generate heat at their surface, allowing them to create images based on these temperatures. However, there are technical problem addressed during research: finding suitable photosemiconductive materials capable of efficiently producing thermally generated signals while also being able to effectively detect small changes within blood vessels caused by inflammable agents like nitrogen oxides emitted due to metabolism processes associated with diseases including breast cancer.

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